Brain scans may predict online therapy success for common mental health issues

NCT ID NCT04191811

Recruiting now Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The goal is to see if moment-to-moment brain activity is a better predictor of success than patient questionnaires. This is an observational study, not a treatment trial, and aims to improve future treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: internet-delivered cognitive behavioral therapy (iCBT)
What this could lead to: If successful, this could lead to a way to predict which patients will benefit most from internet-based therapy, saving time and resources.
What could go wrong: This is an early-stage observational study, not a treatment trial. The brain scan method may not prove useful in predicting outcomes, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression depressive disorder insomnia major depressive disorder psychiatric disorder social phobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DISORDERS DEPRESSION INSOMNIA PSYCHIATRIC DISORDER

Contacts and locations

Locations

Internetpsykiatri
RECRUITING

Huddinge, Stockholm County, 14152, Sweden

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