Insomnia

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This study tests whether a behavioral sleep intervention combined with the drug varenicline can help heavy smokers quit. Researchers will measure sleep quality, smoking habits, and brain activity in 114 participants. The goal is to see if improving sleep reduces negative emotions…

This study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the …

This study compares two anti-rejection drugs in older kidney transplant recipients: a once-daily extended-release version (Envarsus XR) versus the standard twice-daily immediate-release version (Prograf). Researchers will measure changes in thinking, memory, and other cognitive s…

This study tests whether short behavioral therapy sessions can improve sleep and reduce alcohol and cannabis use in young adults aged 18-29 who struggle with insomnia and heavy drinking or marijuana use. Researchers will enroll 800 participants in Washington State and compare tho…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will receive either CBT-I or a patient education program. The main goal is to see if improv…

This study tests whether helping children ages 6-12 who are above average weight and sleep 9 hours or less per night to get about 45 more minutes of sleep can improve their body weight and learning. The sleep extension group will be coached to go to bed 60-90 minutes earlier over…

This study tests whether installing energy recovery ventilators or portable air cleaners in low-income homes can reduce indoor pollutants and mold, and improve asthma control. Researchers will monitor 80 households over one year, measuring lung function, asthma symptoms, and qual…

This study tests whether the insomnia medication lemborexant (Dayvigo) can lower blood markers of brain damage in adults aged 40–65 with insomnia. Twenty participants will take the drug or a placebo for two weeks each, then have their blood tested for proteins linked to Alzheimer…

This study is testing whether wearable devices like activity trackers, EEG headbands, and smartphones can accurately measure sleep stages. Researchers will compare these devices to standard sleep lab tests (polysomnography) in 96 healthy volunteers and people with sleep disorders…

This study tests whether taking the sleep medication suvorexant (Belsomra) nightly for two years can slow the buildup of amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will enroll 200 healthy adults aged 65 and older with no signs of dementia. The go…

This study tests whether a mindfulness-based sleep program for pregnant women with insomnia can prevent depression during and after pregnancy. Researchers will enroll 500 women and compare the program to standard care. The goal is to improve sleep and reduce the risk of perinatal…

This study tests a digital sleep platform that offers different levels of help based on how severe a person's insomnia symptoms are. Over 1,000 adults in Hong Kong with mild sleep issues will take part. The goal is to see if this stepped-care approach can prevent full-blown insom…

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent depression, anxiety, and daytime sleepiness. About 3000 students in Swedish high schools will take part, and their results will be comp…

This study tests whether an online sleep improvement program for pregnant women can reduce stress and prevent postpartum depression and anxiety. Researchers will enroll 114 women early in pregnancy and track their sleep, stress hormones, and mood for months after birth. The progr…

This study tests whether a gentle movement program called Body Awareness Therapy (BAT) can help young adults (ages 20-30) who feel very stressed. Over 8 weeks, one group does BAT twice a week while another group does nothing new. Researchers will measure changes in balance, sleep…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This pilot study is testing a device that sends a mild electrical current to the brain (tACS) to see if it can reduce anxiety and improve sleep in people with generalized anxiety disorder and chronic insomnia. Thirty adults will receive 20 sessions over four weeks. The goal is to…

This study tests whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep faster. Thirty adults with insomnia will be split into three groups: one uses the app with guided meditation, one uses the app without guidance, and one receiv…

This study tests a stepped care model for delivering cognitive behavioral therapy for insomnia (CBT-I) to 1100 adults across 18 districts in Hong Kong. Participants first receive online self-help CBT-I, and those who need more support get therapist-guided sessions. The goal is to…

This study tests whether daridorexant, a sleep medication, can improve sleep in people with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. Sixty-two participants will receive either the drug or a placebo for one month, and their sleep wi…

This study tests whether short, calming virtual reality (VR) sessions can safely reduce anxiety, agitation, and delirium in adult intensive care unit (ICU) patients. Thirty participants will watch nature-based VR content using a headset. The main goal is to see if this approach i…

This study tests whether a parent-led online program can improve sleep in autistic children aged 3 to 7 years. About 130 children will be randomly assigned to one of two behavioral sleep programs for 10 weeks. The goal is to see if the structured program reduces insomnia symptoms…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study tests whether a non-invasive earbud that gently stimulates a nerve in the ear can help adult survivors of childhood leukemia who have trouble sleeping. Forty participants will be randomly assigned to receive either active or sham stimulation nightly for 2 to 8 weeks. T…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study tests a digital program called NiteCAPP Jr, which delivers cognitive behavioral therapy for insomnia (CBT-I) to children aged 6-12. The program aims to improve sleep by teaching healthy sleep habits through interactive online sessions. Researchers will measure how well…

This study tests a web-based version of cognitive behavioral therapy for insomnia (CBT-I) in 60 family caregivers of people with dementia. Caregivers will complete four online sessions focused on sleep habits, relaxation, and changing unhelpful thoughts. The goal is to improve sl…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce fatigue in people with multiple sclerosis. About 70 adults with MS and insomnia will receive CBT-I or an active control. The goal is to see if this talk therapy approach can ea…

This study tests whether adding lower-body strength training to static stretching helps pregnant women with restless legs syndrome (RLS) feel better. Thirty pregnant women with RLS will be split into two groups: one does only stretching, the other does stretching plus strength ex…

This study tests two hands-on treatments—nerve stretches and muscle pressure release—to see which better reduces menstrual cramps, improves sleep quality, and lowers stress in women with Polycystic Ovary Syndrome (PCOS). 38 women aged 18-35 with PCOS and painful periods will be r…

This study compares three common insomnia treatments—two medications (trazodone and daridorexant) and an online behavioral therapy program—in 1,000 women aged 40-62 who are in or near menopause. Participants will take one treatment for 12 months, wear a Fitbit, and complete sleep…

This study compares two easy relaxation methods—Laura Mitchell's technique and Benson's relaxation response—in 38 adults aged 40–60 with moderate to severe COPD. Participants will practice one of the techniques for 15–20 minutes daily over 6 weeks. The goal is to see which method…

This study looks at whether adding pork protein to the diet can help middle-aged women with overweight or obesity who are taking GLP-1 medications (like Ozempic or Wegovy) maintain muscle and improve well-being. Over 12 weeks, 75 women will continue their medication and eat prote…

This study tests whether giving pregnant women personalized heat alerts, cooling tips, and indoor air cleaners can reduce their exposure to heat and air pollution, and improve sleep quality. About 102 healthy pregnant women in Italy and Cyprus will be split into groups: some get …

This study tests whether a 15-minute virtual reality meditation session each night can help adults aged 25 to 50 with insomnia fall asleep faster and sleep more soundly. Thirty participants will either use the VR relaxation or be placed on a waiting list. Researchers will track s…

This study is testing a version of Cognitive Behavioral Therapy for Insomnia (CBT-I) that has been adapted specifically for teenagers. The treatment includes healthy sleep habits, a consistent sleep schedule, and relaxation techniques. Researchers will compare teens who receive t…

This study compares the effectiveness, safety, and long-term benefits of commonly used insomnia medications, including prescription drugs like zolpidem and trazodone, and over-the-counter options like melatonin and diphenhydramine. Researchers will enroll 1,200 adults with chroni…

This study tests whether a daily dose of tasimelteon helps children aged 2 to 17 with insomnia fall asleep faster and sleep better. About 420 participants will receive either the drug or a placebo. The goal is to improve sleep and daytime functioning without serious side effects.

This study tests whether female health sciences students can improve their sleep patterns and reduce social jet lag by doing acupressure on themselves every day for 12 weeks. Half the participants will use real acupressure points, while the other half will use sham (fake) points,…

This pilot study tests whether a device called Cereset Research can help caregivers of people with dementia who feel stressed, anxious, or have trouble sleeping. The device plays tones that echo the brain's own rhythms, aiming to improve heart rate variability and reduce stress. …

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests whether a simple breathing exercise called the 4-7-8 technique can help people sleep better, feel less pain, and recover faster after bladder surgery. About 68 adults having this surgery will be randomly assigned to either learn the breathing exercise or receive …

This study compares an intelligent digital cognitive behavioral therapy (CBT) program against traditional sleep medications for treating insomnia. Researchers will enroll 200 adults with insomnia to see which approach improves sleep, anxiety, and depression more, and which is mor…

This study tests whether a structured exercise program can improve heart rate variability (a measure of heart health), reduce menopausal symptoms, and enhance sleep and quality of life in postmenopausal women aged 45 to 65. Forty women will either join a supervised 12-week exerci…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This small pilot study tests whether a special rocking bed (Somnomat Casa) can improve sleep quality in people with Parkinson's disease. Fifteen participants will use the bed at home for two months, and researchers will measure how acceptable and helpful the treatment is. The goa…

This study tests whether a type of talk therapy for insomnia, delivered via telemedicine, can improve sleep and reduce cannabis use in adults who have trouble sleeping and use cannabis regularly. 200 participants will be randomly assigned to either cognitive behavioral therapy fo…

This study tests whether a breathing therapy device (adaptive servo ventilation) can reduce insomnia severity in adults with moderate to severe chronic insomnia. About 25 participants will use the device and report changes in sleep quality and how long it takes to fall asleep ove…

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

This study tests whether a smartphone app that helps improve sleep, along with a wearable activity tracker, can support brain health in older adults (65+) after hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surge…

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This study looks at how to best offer cognitive behavioral therapy for chronic insomnia to older veterans at 20 VA clinics. About 20 veterans will take part to see if the therapy helps them sleep better and feel better. The goal is to find the best way to bring this effective tre…

This study aims to help socioeconomically disadvantaged adults who struggle with insomnia. Researchers will compare two types of behavioral therapy delivered remotely (by phone or video) to see if a shorter treatment works as well as the standard longer one. 350 adults from prima…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This phase 2 trial tests whether taking CBD before bed can improve sleep quality after a late evening high-intensity workout. Twenty healthy adults will each complete a rest session and two exercise sessions, receiving either CBD or a placebo. Sleep is measured overnight using br…

This study tests a device called Cereset Research to see if it can improve how the body handles stress, anxiety, and insomnia. About 200 adults with these symptoms will use the device while researchers measure heart rate and blood pressure changes. The goal is to find a non-drug …

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to 12 months of exercise, cognitive behavioural therapy for insomnia (CBT-I), or both. The goal is…

This study tests whether a special online therapy for insomnia, adapted for people with ulcerative colitis (UC), is helpful and practical. About 20 adults with active UC and insomnia will take part. They will complete online questionnaires, keep a daily sleep diary, and attend 5 …

This study tests whether a drug called pimavanserin can improve sleep in veterans with post-traumatic stress disorder (PTSD) who also have insomnia. About 60 veterans will receive either the drug or a placebo for 8 weeks. The goal is to see if it reduces insomnia severity and imp…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study looks at whether a custom mouthpiece that gently moves the lower jaw forward during sleep can improve sleep quality, heart rate patterns, and blood oxygen levels. About 24 healthy adults aged 40-65 will wear both the active device and a placebo device to compare effect…

This study tests a group therapy program called Sleep School for people with chronic insomnia. 250 participants will either attend Sleep School once a week for six weeks or receive standard short counseling from a nurse. The goal is to see if Sleep School reduces insomnia symptom…

This study tests whether a device that sends mild electrical currents to the brain (hi-tACS) can improve sleep in people with neuroimmune diseases like multiple sclerosis who also have insomnia. Eighty participants will receive 20 sessions of the stimulation or a sham treatment. …

This study tests a web-based program called NiteCAPP designed to improve sleep in people caring for a loved one with dementia, especially those living in rural areas. One hundred caregiver-patient pairs will use the program for 4 weekly sessions plus follow-up boosters. Researche…

This study tests an internet-based sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers will check if the course is easy to use and helpful for people in Saskatchewan. About 56 adul…

This pilot study tests whether adding a digital insomnia treatment (CBT-I) to standard suicide-focused therapy (DBT) helps reduce suicidal thoughts and self-harm in teens aged 12-18 who are at high risk for suicide. Forty-four participants will be randomly assigned to receive eit…

This study tests whether adding sauna blanket sessions to an online insomnia therapy program helps people sleep better. Forty adults with insomnia will all receive digital cognitive behavioral therapy, and half will also use a sauna blanket for 15 minutes several times a week. Th…

This study looks at whether aerobic exercise can help college students with insomnia as much as a digital therapy program. Fifty students will be split into two groups: one does exercise, the other uses a sleep app. Researchers will track sleep quality, mood, and stress to see wh…

This study tests whether adding Five Shu point acupuncture to standard acupuncture can improve sleep in people with insomnia linked to a Heart-Spleen deficiency pattern. 46 adults will receive either standard acupuncture or standard plus Five Shu points over 20 sessions in 28 day…

This study tests two treatments for insomnia in veterans who also have PTSD. One is a brief behavioral therapy focused on sleep habits, and the other is a relaxation technique. Researchers want to see which one improves sleep and daily life more, and if benefits last over time. A…

This study compares two behavioral programs for people with chronic pain, chronic insomnia, and long-term opioid use. One program uses cognitive behavioral therapy for insomnia (CBT-I), the other is standard treatment. The goal is to see if improving sleep can also reduce opioid …

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This study looks at whether a 16-week program combining mindfulness meditation and Nordic walking pole exercise can improve physical function, mood, and sleep in adults aged 55 and older. About 1,500 participants will take part in the program and be assessed at several points. Th…

This pilot study at Stanford University is testing whether giving rTMS (a non-invasive brain stimulation) in the morning or evening works better for treating insomnia. Ten adults with insomnia will receive ten sessions over two weeks. Researchers will track sleep quality and brai…

This study tests whether a proven sleep therapy (CBT-I) can improve how the brain regulates emotions, helping treat depression and anxiety. Researchers will use brain scans to see changes in emotion networks. 120 adults with insomnia and depression will participate. The goal is t…

This study tests an internet-based therapy program called the Sleep Course, designed to help public safety personnel (like police, firefighters, and paramedics) who have trouble sleeping. The program teaches skills to manage sleep difficulties and includes optional support from a…

This pilot study tests whether a non-invasive headset that delivers mild electrical stimulation to nerves behind the ear can safely improve sleep in adults who are blind or severely sight impaired. Sixty participants will use the device for 30 minutes a day, five times a week for…

This study tests whether a non-medication sleep program (CBT-I) can improve sleep, PTSD symptoms, and heart health in older adults with PTSD who still have sleep problems after PTSD therapy. About 167 veterans aged 50 and older will receive PTSD therapy first, then the sleep prog…

This study compares two behavioral sleep training methods for infants with insomnia: 'bedtime checking' (only at bedtime) and 'standard checking' (also during night-wakings). The goal is to see which approach improves infant and parent sleep faster while being more acceptable to …

This study compares two approaches for older adults with knee osteoarthritis and insomnia: personalized exercise coaching alone versus exercise plus a digital insomnia treatment. Researchers want to see if adding sleep therapy leads to greater pain relief. The trial involves 288 …

This study tests whether a mobile health program (mPATH) can help low-income older adults who have trouble sleeping and are not very active. Participants will use the program to increase physical activity, and researchers will measure changes in memory and sleep quality. The goal…

This study is testing whether taking a daily saffron extract supplement (30 mg) for six weeks can improve sleep quality in middle-aged adults who have mild-to-moderate sleep problems. Researchers will measure sleep using a wrist-worn device and track other factors like mood and s…

This study is testing whether a wearable device that plays personalized low-frequency sounds (like pink noise) can help people with insomnia sleep better. Forty adults with sleep problems will use the device for 12 weeks, and their sleep will be measured with overnight brain-wave…

This study tests whether person-centered behavioral programs can improve sleep in first-time mothers with insomnia. 135 women will either receive a sleep management program, an aerobic exercise program, or usual care. The main goal is to see if these approaches reduce insomnia se…

This study tests a brief group therapy called Acceptance and Commitment Therapy for insomnia (ACT-i) in 76 adults aged 18-59 with chronic insomnia and mild depression or anxiety. Participants are randomly assigned to either ACT-i or a general support group. The goal is to see if …

This study tests a type of hypnotherapy called E2R for people with chronic insomnia. It compares E2R to usual care (like sleep medications) to see if it reduces insomnia severity. About 136 adults with chronic insomnia will take part, and the goal is to find a safer, non-drug opt…

This study tests whether a brief behavioral treatment for insomnia (BBTi) — guided by a nurse or through a mobile app — can improve sleep, mood, and thinking in people recovering from traumatic brain injury (TBI). About 93 participants with chronic TBI and insomnia will be assign…

This study looks at whether complex decongestive physiotherapy (CDP) can improve sleep quality and quality of life in women with stage 2 breast cancer-related lymphedema. CDP includes massage, skin care, compression bandages, and exercises. The study will follow 31 women for 4 we…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study looks at how tai chi and yoga affect flexibility, anxiety, and sleep in healthy women aged 18 to 45. Participants will do either tai chi or yoga for 8 weeks, twice a week. Researchers will measure changes using simple tests and questionnaires to see which activity offe…

This study tests whether a daily probiotic supplement called Limosilactobacillus reuteri LM1063 can improve sleep in healthy adults who have poor sleep quality. Over 8 weeks, 80 participants will take either the probiotic or a placebo, and researchers will measure sleep using bot…

This study tests whether a headband that uses sound waves (acoustic resonance therapy) can improve sleep quality in people with moderate to severe chronic insomnia. It compares the headband to a standard behavioral therapy (CBT-I) over 6 weeks. About 60 adults will participate to…

This study tests a special type of talk therapy called Multi-Modal Cognitive Processing Therapy (MMCPT) for people with posttraumatic stress disorder (PTSD). Sixty adults with PTSD will either receive 12 weekly therapy sessions or standard care. Researchers will track changes in …

This study tests an online program (eCBTi+) that teaches older adults with insomnia and memory concerns how to improve sleep, manage anxiety and low mood, and potentially protect brain health. About 275 people aged 60 and older will use the program or a control version for severa…

This study tests whether limiting social media use to a set amount each day can reduce loneliness, fear of missing out (FoMO), and improve sleep quality in university students. Seventy students aged 18-25 who use social media at least 2 hours daily will be randomly assigned to ei…

This study tests whether older adults (ages 65-74) can improve their balance, reduce fear of falling, and sleep better by doing combined physical and mental exercises at home via video calls with a physiotherapist. Participants will perform 4 weeks of dual-task exercises—like wal…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This study tests whether a digital sleep therapy program (Sleepio) can improve quality of life and movement in 142 adults with fibromyalgia who also have trouble sleeping. Participants will use the program at home for 10 weeks and wear devices to track sleep and activity. Researc…

This study tests a virtual, 4-session sleep program based on cognitive behavioral therapy for insomnia (CBT-I) in 198 cancer survivors. Participants are randomly assigned to the program or usual care. The goal is to see if the program reduces insomnia severity, improves sleep qua…

This study looks at whether art therapy, delivered through virtual reality glasses or in person, can help reduce anxiety and improve sleep and well-being in people with colorectal cancer. 78 patients receiving chemotherapy will be randomly assigned to one of three groups: virtual…

This study tests a sleep improvement program designed specifically for older Korean immigrants who have trouble sleeping. The program adapts standard sleep therapy to fit Korean culture and language. Researchers will measure sleep quality and gather feedback from 32 participants …

This study tests whether a virtual cognitive behavioral therapy program can help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home. The goal is to see if the program is easy to use and helpful for improving…

This study tests whether eating pistachios daily and receiving coaching on healthy habits can improve sleep quality in midlife women aged 45-65 who have poor sleep. Participants will eat either pistachios or potato chips for a month and attend a one-hour coaching session. Researc…

This study tests whether pressing small seeds on specific ear points can help people with functional dyspepsia (chronic stomach discomfort) who also have insomnia. Researchers will track symptom relief and sleep quality in 176 adults over 8 weeks, and explore how the treatment af…

This study tests two techniques to help people with insomnia: mental imagery (turning negative thoughts into positive ones) and using a scent during sleep to strengthen that positive feeling. 120 adults aged 18-45 with insomnia will be split into four groups to compare these meth…

This study tests whether a 12-week supervised exercise program done during dialysis can improve muscle mass, strength, sleep, and quality of life in adults over 40 with chronic kidney disease. Participants are randomly assigned to either exercise during the first 90 minutes of di…

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women with early-stage breast cancer who are overweight and have insomnia will either get a sleep therapy (CBT-I) or sleep education before starting a weight loss program. Researchers …

This study tests whether personalized exercise and a gentle nerve stimulation device can reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise plus standar…

This study tests a smartphone app called iCANSleep, which provides a type of talk therapy (CBT-I) to help cancer survivors with insomnia. Researchers will enroll 146 Canadian cancer survivors who have trouble sleeping and compare those using the app to a waitlist group. The goal …

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help older African Americans sleep better and think more clearly. Twenty participants will receive 8 weekly sleep training sessions via Zoom or a single education session. Researchers will measure slee…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study tests whether a respiratory rehabilitation program (exercise and education sessions over 8 weeks) can improve sleep quality in people with stable COPD. 90 adults aged 50 and older will be randomly assigned to either the rehab program or usual care. Sleep will be measur…

This study tests whether a nurse-supported mobile app that teaches healthy sleep habits can reduce insomnia in people caring for a family member or friend with cancer. About 208 caregivers will either use the app for 6 weeks with weekly nurse check-ins or receive basic sleep tips…

This study tests a 6-week mindfulness-based program designed to improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 women and track changes in sleep quality, stress levels, and how acceptable and feasible the program is. The goal is to see if…

This study looks at whether adding yoga to usual care can reduce insomnia severity in adults aged 18-65 with chronic insomnia. 72 participants will be split into three groups: yoga plus standard care, stretching plus standard care, or standard care alone. The main goal is to see …

This study tests a guided online version of cognitive behavioral therapy for insomnia in 80 people who have had a moderate or severe traumatic brain injury at least a year ago and currently have insomnia. Participants will either receive the online therapy (6 modules over 6-9 wee…

This pilot study tests a wellness program for adults with cystic fibrosis (CF) to see if it helps with fatigue, sleep, and physical activity. The program includes 8 coaching sessions on topics like balancing activity and rest, improving sleep, and managing stress. Researchers wil…

This study tests whether a special 3D exercise program (the Schroth method) can improve back muscle endurance, sleep, and quality of life in 60 adolescents aged 12-18 with hyperkyphosis (excessive rounding of the upper back). Participants will do the exercises for at least 3 mont…

This study tests whether a smartphone app, with or without personal coaching by phone, can improve sleep in children aged 6–12 with autism and insomnia. Parents use the app to learn behavioral sleep strategies. The trial will enroll 195 families and also measure effects on childr…

This study tests whether a daily nutritional supplement can improve sleep quality in adults aged 35-65 who have mild sleep problems. About 140 participants will take either the supplement or a placebo for several weeks, and sleep will be tracked using a special ring and questionn…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can reduce impulsivity and risk-taking in young people aged 12-24 who have trouble sleeping. Researchers will measure changes in impulsive behavior and sleep quality. The goal is to see if improving sleep …

This study tests a program called TAILOR, which uses sleep-focused therapy to help teens with insomnia who are also having suicidal thoughts. The goal is to see if improving sleep can lower their risk of suicidal behavior. The study will enroll 235 teens aged 11-18 and track chan…

This study is testing whether a special drink called Avnace eZZe can help people with insomnia sleep better. 75 adults with sleep and anxiety issues will drink it each night for 28 days. Researchers will track sleep quality using questionnaires and a sleep monitor to see if it wo…

This study tests whether a gentle electrical current applied to the head can improve sleep in 100 adults with insomnia. Participants will receive the stimulation and complete sleep questionnaires and brain scans to measure changes in brain activity. The goal is to see if this non…

This study tests whether a digital cognitive behavioral therapy app (Sleepio) combined with a doctor-supervised medication tapering plan can help people stop using sleeping pills. Researchers will recruit 430 adults from primary care clinics who have used sleep aids for over 6 mo…

This study tests whether using virtual reality for relaxation exercises can reduce pain and improve sleep better than traditional relaxation methods in people recovering from hip or knee replacement surgery. About 82 adults who speak Turkish and have no mental or sleep disorders …

This study tests a 4-week online course designed to help adults who experience parasomnias—unwanted sleep events like sleep terrors, sleepwalking, and nightmares. The course teaches safety planning, relaxation, and therapy techniques. Researchers will measure whether it reduces h…

This study tests whether cognitive behavioral therapy for insomnia (CBTi) can improve sleep, blood sugar levels, and quality of life in adults with type 1 diabetes. Fifteen participants will either receive 8 virtual CBTi sessions or health education emails and calls over 12 weeks…

This study tests whether a daily supplement called Levagen+ (PEA) can help trained cyclists recover from a week of intense training. Twenty healthy athletes will take either the supplement or a placebo for 45 days. Researchers will measure cycling performance, inflammation, stres…

This study tests whether a type of talk therapy focused on sleep (CBT-I) can improve sleep, reduce psychotic symptoms, and enhance quality of life in people with treatment-resistant schizophrenia. About 60 adults with chronic psychosis and long-term sleep problems will receive ei…

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help people with bipolar disorder feel better. About 150 adults who are already on medication for bipolar disorder will track their eating, sleep, and mood for 2 weeks, then follo…

This study tests a smartphone app called StandUPTV that alerts adults after 30 minutes of evening screen time, encouraging them to stand or move. Researchers want to see if this can reduce total sitting time and improve physical activity, sleep quality, and blood sugar levels. Th…

This study tests whether hormone replacement therapy (HRT) or cognitive behavioral therapy (CBT-I) can help perimenopausal women sleep better. Fifty-four women with insomnia and hot flashes will receive either HRT, weekly CBT-I sessions, or sleep hygiene tips for 8 weeks. Researc…

This study looks at whether gentle massage can help preterm babies (born 35-37 weeks) in the NICU sleep better, feel less stressed, and be more comfortable. Forty babies will either receive a 15-minute massage three times a day for three days or standard care. Researchers will me…

This study tests whether a nutritional supplement called 'Think Tank' can improve thinking and memory in middle-aged women after they experience stress. Forty healthy women aged 40-60 will take either the supplement or a placebo and then complete cognitive tests. The goal is to s…

This study tests a nurse-led program called Dreamcatchers to help children aged 6-12 with cancer sleep better. The program uses relaxation techniques like breathing exercises and muscle relaxation instead of sleep medications. About 68 children will take part to see if this appro…

This study compares two types of talk therapy for insomnia in 160 active-duty military members who have had a mild traumatic brain injury and still have symptoms like trouble sleeping, thinking, or mood issues. One therapy is longer (6 sessions) and the other is shorter (4 sessio…

This study tests whether a smartphone app called SleepUp can help people with insomnia. The app provides cognitive-behavioral therapy (CBTi) and extra features like meditation and relaxation sounds. Researchers will compare the app to standard therapy with a psychologist and to b…

This study tests whether a smartphone app called Sleepio, which teaches better sleep habits, can help teens ages 14-18 who were recently hospitalized for suicide risk and also have insomnia. Half the teens will use the app plus get their usual care, while the other half gets usua…

This study tests whether an online insomnia treatment, followed by either a meditation program or pain education, can reduce pain in adults with chronic low back pain and insomnia. About 300 participants will first complete a 9-week internet-based cognitive behavioral therapy for…

This study tests whether a sleep hygiene education program can improve sleep quality and reduce depression in menopausal women. 500 women will be randomly assigned to receive the education or be in a control group. The program is based on the IMB model and delivered online. The g…

This study looks at whether eating nuts can help reduce symptoms of depression, anxiety, and stress, and improve memory and thinking skills in young adults. Researchers will enroll 135 university students aged 18 to 25 and measure changes in mood, cognitive function, and a brain-…

This study tests whether using a special blanket for 4 weeks can improve sleep in 672 young people aged 16-24 who have trouble sleeping. Participants are split into three groups: two groups get different blankets, and one group gets no blanket for comparison. The goal is to find …

This study tests a culturally and language-adapted internet-based cognitive behavioral therapy (i-CBT) for Farsi/Dari-speaking youth migrants and refugees aged 15-29. The goal is to reduce symptoms of common mental health problems like anxiety, depression, and stress. Participant…

This study tests whether trazodone, a medication often used for depression, can improve sleep in adults aged 65 and older with chronic insomnia. Forty participants will take either trazodone or a placebo for 28 days, then switch after a break. They will track their sleep with dia…

This pilot study is testing whether a web-based insomnia treatment called SHUTi can help Black/African American prostate cancer survivors sleep better. Forty participants will be randomly assigned to either the SHUTi program or an educational website. The study will check if the …

This study tests a quick, 5-day group therapy program for active-duty military and veterans who struggle with PTSD, insomnia, and nightmares. 160 participants will receive either cognitive-behavioral therapy or sleep education, both combined with a proven PTSD writing therapy. Th…

This trial tests whether dynamic lighting that mimics daylight can improve sleep quality, energy levels, and well-being in radiographers. 18 participants will work under enhanced or normal lighting, answer surveys, and provide saliva samples. Researchers want to find the best lig…

This study tests whether an online, therapist-guided program for insomnia can also reduce anxiety symptoms. 98 adults with both chronic insomnia and anxiety will either start the program immediately or after a delay. The program includes sleep education, behavioural strategies, a…

This Phase 3 trial tests whether the drug solriamfetol can reduce excessive sleepiness in people with shift work disorder. About 520 adults who work night shifts will take either solriamfetol or a placebo daily for 12 weeks. The study measures how well they stay awake and their o…

This study tests whether a lotion containing 1% hemp extract (CBD) plus 10% urea can relieve itching, improve skin moisture, and help sleep in people with scleroderma. About 36 adults with chronic itching will use both the CBD lotion and a plain urea lotion at different times to …

This study tests whether a special memory support program can help people aged 50 and older remember and stick to their sleep treatment. The program uses simple memory strategies alongside standard sleep therapy. Researchers will track sleep quality, daily functioning, and life s…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This study looks at 600 adults with chronic insomnia to see if those who sleep less than 6 hours respond differently to treatment than those who sleep longer. Participants first receive 8 weeks of cognitive behavioral therapy (CBT-I). If that doesn't help, they are randomly assig…

This study tests whether a non-invasive brain stimulation technique called TMS can improve sleep in people with insomnia. 144 adults with moderate to severe insomnia will receive either real TMS to different brain areas or a sham (inactive) treatment over two weeks. Researchers w…

This study tests whether using a low-frequency vibrating mat at home for 15 minutes, several times a week, can improve stress recovery, sleep quality, mood, and attention in healthy adults aged 18-45. Fifty participants will be randomly assigned to use the mat or lie quietly for …

This study tests a new approach to improve sleep in people aged 60+ with mild cognitive impairment (MCI). It combines a gentle brain stimulation technique called TMS with an internet-based sleep therapy program. The goal is to see if this combo can ease insomnia and possibly boos…

This study tests two ways of delivering cognitive behavioral therapy for insomnia (CBT-I) to people with multiple sclerosis: one-on-one telehealth sessions or a self-guided web program. Researchers will compare these to usual care to see which improves sleep, reduces fatigue, and…

This study tests a combined treatment for older adults who wake up often to urinate and have trouble sleeping. The goal is to see if treating both problems together can reduce bathroom trips and improve sleep quality. Researchers will track changes over 4 months in 192 participan…

This study is testing whether inhaling lavender oil three times a week for a month can reduce anxiety, improve sleep quality, and lower blood pressure in people with primary hypertension. Fifty participants will be randomly assigned to either receive lavender oil inhalation plus …

This study tests whether wearing a vibrating device on the forehead for 15 minutes before bed can improve sleep and memory in people with chronic insomnia. 120 adults aged 18-65 with trouble falling asleep will use either the active device or a sham version for 4 weeks. Participa…

This study tests whether a medication called RE03 (dexmedetomidine), already used in intensive care, can improve sleep in people with PTSD who have trouble sleeping or nightmares. Twenty-four adults with PTSD will receive either the drug or a placebo in random order, and their sl…

This study tests a type of talk therapy called cognitive-behavioral therapy for insomnia (CBT-I) in children aged 7 to 11 who have trouble sleeping. Some children will get CBT-I that includes a technique called sleep restriction therapy, while others get CBT-I without it, and a t…

This study tests whether adding simple mental tasks (like memory games) to water aerobics helps older women improve their thinking and memory more than water aerobics alone. About 98 inactive women aged 60-75 will take part in a 12-week program. Researchers will measure changes i…

This study will track jaw muscle activity in 42 adults with chronic jaw pain and teeth grinding (bruxism) who use a custom mouth splint at night. Participants will wear a portable device for 24 hours to measure muscle activity before starting the splint, two weeks later, and afte…

This pilot study will give 70 children aged 6-13 either a daily almond butter snack or a chocolate spread snack for 8 weeks. Researchers will measure changes in gut and mouth bacteria, blood markers, and digestion. The goal is to see if almonds can improve gut health and reduce f…

This study looks at how the timing of aerobic exercise—morning versus late afternoon—affects deep sleep and body temperature. Researchers will compare endurance athletes with inactive people to see who is more affected. The goal is to understand how exercise timing can improve sl…

This observational study looks at how sleep quality influences cognitive flexibility, physical activity, body awareness, and reaction time in people with multiple sclerosis. Researchers will compare those with good and poor sleep using questionnaires, computer tests, and a wearab…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study follows 102 men with metastatic hormone-sensitive prostate cancer who are taking standard drugs (abiraterone, apalutamide, enzalutamide, or darolutamide) plus hormone therapy. Researchers will check thinking skills, fatigue, mood, and sleep at the start, 3 months, and …

This study looks at how sleep quality relates to cognitive functions like attention, memory, and problem-solving in 75 healthy adults aged 18-35. Participants will wear a sleep tracker for five nights and complete thinking tests. The goal is to better understand the link between …

This study looks at how Cognitive Behavioral Therapy for Insomnia (CBT-I) affects the body's stress system, including the hormone cortisol. Researchers will track 115 adults with chronic insomnia, measuring sleep and stress markers before, during, and after therapy. The goal is t…

This study aims to find biological markers in spinal fluid and blood that could signal the start of prion disease before symptoms appear. Researchers will follow 150 people who carry a genetic mutation for prion disease, along with family members and healthy volunteers. Participa…

This study looks at how getting only 4 hours of sleep for three nights, or having insomnia, changes the way people process and control their emotions. Researchers will use brain scans and behavioral tests to compare these groups with people who sleep normally. The goal is to bett…

This study looks at whether limiting food intake to an 8-hour window each day can improve sleep, physical activity, and reduce sitting time in college-aged women. Thirty-six female students at the University of Georgia will either follow this eating pattern or receive basic nutri…

This study looks at whether eating smooth peanut butter every day for 8 weeks can improve gut and metabolic health in children aged 6 to 13. Researchers will compare kids who eat peanut butter to those who eat a nut-free chocolate spread. The goal is to see changes in gut bacteri…

This study looks at 135 preschool children aged 3 to 6 to see if being raised by relatives, caregivers, or in daycare affects their development, sensory processing, and sleep. Researchers will use standard tests to measure these areas and compare results across different caregivi…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study compares how people with chronic insomnia and healthy controls recognize facial emotions. Using eye-tracking, researchers will look for subtle differences in attention and emotional processing. The goal is to better understand social challenges linked to insomnia and i…

This study looks at how a brain chemical called norepinephrine affects sleep and thinking in older adults with insomnia, who are at higher risk for Alzheimer's. Researchers will measure this chemical in the blood and use a light therapy to try to improve sleep and mental sharpnes…

This study looks at young women with anorexia nervosa to see if changes in a gene related to appetite and wakefulness (the orexin gene) are linked to how severe their eating disorder is, whether they have depression, and how well they sleep. Researchers will compare these women t…

This study looks at how quickly losing weight through dehydration (using a sauna) affects combat athletes' sleep quality, thinking skills, and leg strength. Twelve athletes with prior weight-cutting experience will be monitored before and after losing 3% of their body weight. The…

This study looks at how carpal tunnel syndrome (CTS) severity relates to sleep quality. Researchers will compare 120 CTS patients with healthy controls using ultrasound and sleep questionnaires. The goal is to better understand the connection between nerve compression and poor sl…

This study tests whether installing cooling equipment in low-income homes in Bangladesh can reduce heat stress and improve health. About 1,500 participants will have sensors placed inside and outside their homes and wear monitors to track heart rate, sleep, and other health measu…

This study looks at whether the number of steps breast cancer patients take each day, tracked by a smartwatch, is linked to how well their treatment works. About 82 women with non-metastatic HER2-negative breast cancer will wear a Huawei Fit 2 smartwatch during chemotherapy befor…

This study looks at how cognitive behavioral therapy for insomnia (CBT-I) changes a specific brain receptor (mGluR5) in people with major depression. 42 adults with depression and insomnia will receive online CBT-I and undergo PET brain scans before and after treatment. The goal …

This study looks at whether sleep quality is linked to gum disease (periodontitis). Researchers will measure sleep quality, fatigue, and certain substances in saliva from 48 healthy adults with or without gum disease. The goal is to better understand how oral health and sleep are…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track how insomnia develops over the first year, using questionnaires to measure sleep quality and severity. The goal is to understand what factors—like treatment type or em…

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study checks if Samsung smartwatches can accurately measure blood pressure, heart rate, oxygen levels, anxiety, and sleep quality in 60 patients waiting for disc herniation surgery. Researchers compare smartwatch readings to standard medical devices and questionnaires. The g…

This observational study follows 100 pregnant women with gestational diabetes to see how sleep quality, anxiety, eating habits, and lifestyle relate to blood sugar control and birth outcomes. Participants complete questionnaires and undergo glucose monitoring either at home or du…

This study looks at how sleep problems affect people with ulcerative colitis, a type of inflammatory bowel disease. Researchers will study 152 participants to see how sleep quality relates to gut bacteria, nerve function, and disease activity. The goal is to understand the connec…

This study looks at how chronic sleep problems and pain sensitivity are connected in people with long-term low back pain and insomnia. Researchers will use brain imaging, pain tests, and blood/stool samples in 80 adults to understand the underlying brain mechanisms. The goal is t…

This study aims to translate and validate a French version of the Sleep Regularity Questionnaire (SRQ), a tool that measures how consistent a person's sleep schedule is. Researchers will enroll 50 adults with chronic insomnia or circadian rhythm disorders, who will fill out the q…

This study follows about 785 pregnant women with insomnia to see if taking the sleep medication QUVIVIQ affects pregnancy or baby health. Researchers will compare outcomes like birth defects and pregnancy complications between women who took QUVIVIQ and those who used other insom…

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The…

This study looks at how insomnia affects how often children and teens use their positive airway pressure (PAP) machines for obstructive sleep apnea. Researchers will track 82 kids aged 8-18 who are starting PAP therapy and measure their machine use over 90 days. The goal is to un…

This study looks at whether people with insomnia need different amounts of anesthesia during a digestive endoscopy compared to those who sleep well. Researchers will track the total dose of anesthetic drugs used and watch for side effects. Over 3,300 adults aged 18–64 are being r…

This study compares how much etomidate (a sedative) is needed during digestive endoscopy between people with insomnia and those with normal sleep. Researchers will enroll 840 adults aged 18-64. The goal is to see if insomnia affects sedation requirements, which could help persona…

This observational study looks at whether people with insomnia need a different amount of the sedative rimazolen during a digestive endoscopy compared to those who sleep normally. Researchers will track 840 adults aged 18-64 to see if sleep problems affect sedation requirements a…

This study looks at whether people with insomnia need more or less of the sedative ciprofol during a digestive endoscopy. Researchers will compare 840 patients—some with insomnia and some with normal sleep—to see if sleep problems affect sedation requirements. The goal is to impr…