Brain scans reveal how insomnia treatment may lift depression

NCT ID NCT07076342

Recruiting now Knowledge-focused Sponsor: Stony Brook University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how cognitive behavioral therapy for insomnia (CBT-I) changes a specific brain receptor (mGluR5) in people with major depression. 42 adults with depression and insomnia will receive online CBT-I and undergo PET brain scans before and after treatment. The goal is to understand the brain chemistry link between better sleep and improved mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cognitive Behavioral Therapy for Insomnia (CBT-I) and PET scan tracer [11C]ABP688
What this could lead to: If successful, this could reveal a brain mechanism explaining why improving sleep helps depression, potentially guiding new treatments.
What could go wrong: This is a small, early-phase mechanistic study with only 42 participants, so results may not apply widely. It aims to understand biology, not test a new therapy.

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Conditions

The condition(s) this trial relates to.

insomnia major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Locations

Stony Brook University: Dept of Psychiatry
RECRUITING

Stony Brook, New York, 11794, United States

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