Brain scans reveal how insomnia treatment may lift depression
NCT ID NCT07076342
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how cognitive behavioral therapy for insomnia (CBT-I) changes a specific brain receptor (mGluR5) in people with major depression. 42 adults with depression and insomnia will receive online CBT-I and undergo PET brain scans before and after treatment. The goal is to understand the brain chemistry link between better sleep and improved mood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cognitive Behavioral Therapy for Insomnia (CBT-I) and PET scan tracer [11C]ABP688
What this could lead to
If successful, this could reveal a brain mechanism explaining why improving sleep helps depression, potentially guiding new treatments.
What could go wrong
This is a small, early-phase mechanistic study with only 42 participants, so results may not apply widely. It aims to understand biology, not test a new therapy.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Stony Brook University: Dept of Psychiatry
RECRUITINGStony Brook, New York, 11794, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••