Could a single injection silence fatal brain disease?
NCT ID NCT07444580
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the right dose, while also measuring how well it lowers the protein levels.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Columbia University Medical Center
RECRUITINGNew York, New York, 10032, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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