Sleep drug shows promise for dual diagnosis of alcoholism and PTSD

NCT ID NCT06679062

Recruiting now Disease control Sponsor: Pharmacotherapies for Alcohol and Substance Use Disorders Alliance Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study measures changes in sleep quality and alcohol cravings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: suvorexant
What this could lead to: If it works, this could point toward a new way to treat insomnia in people with both alcohol use disorder and PTSD, potentially helping them reduce drinking.
What could go wrong: This is a small, early-phase trial with only 76 people and a short 14-day treatment period. Results may not apply to everyone, and suvorexant may not work better than placebo.

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Conditions

The condition(s) this trial relates to.

alcohol abuse insomnia post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER (AUD) INSOMNIA POST TRAUMATIC STRESS DISORDER (PTSD)

Contacts and locations

Locations

The University of Texas Health Science Center - Houston
RECRUITING

Houston, Texas, 77054, United States
University of California - Los Angeles
RECRUITING

Los Angeles, California, 90095, United States

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