ALCOHOL USE DISORDER (AUD)

This study tests whether a non-invasive brain stimulation technique called deep TMS can help veterans with alcohol use disorder stay sober longer. Researchers will use brain scans to see how the treatment affects emotional processing and drinking behavior. About 100 veterans will…

This study is testing whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and effective. The goal is to improve h…

This study tests whether combining ketamine with real-time brain training (neurofeedback) can help people with alcohol use disorder reduce their drinking. About 75 adults who want to cut back or stop drinking will receive either ketamine or a placebo, along with real or fake neur…

This study tests whether probenecid, a medicine currently used for gout, can help people with alcohol use disorder drink less and feel less craving. About 120 adults who drink heavily will take either probenecid or a placebo daily for 16 weeks. Researchers will measure cravings i…

This study tests whether two doses of LSD can help people with alcohol use disorder drink less heavily. 128 adults who have recently stopped drinking will receive either a moderate-to-high dose of LSD or a very low dose. The trial will track their drinking over 12 weeks and use b…

This early-stage study tests whether the psychedelic DMT, combined with talk therapy, can help people with alcohol use disorder drink less. About 63 adults with the condition will receive either DMT or a placebo in a controlled setting. Researchers will monitor safety and measure…

This study tests whether a medication that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. Researchers want to understand how stress plays a role in drinking. About 184 adults who want to cut back or quit drinking will take the…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce the urge to drink alcohol and lower heavy drinking days. About 86 adults with alcohol use disorder will receive either real or sham TBS over the front part of …

This study explores whether suvorexant, a drug used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. Researchers will compare suvorexant to a placebo in 180 adults (ages 18-75) with AUD who are undergoing detox…

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive either the drug or a placebo for 4 weeks. The goal is to see if it lowers cue-induced craving…

This study looks at whether adding a smartphone app to standard medication can help Veterans with alcohol use disorder drink less heavily. About 330 Veterans from VA primary care will either get medication alone or medication plus the app. The goal is to see if the app makes it e…

This study is creating and testing a short, virtual therapy program for LGBTQ+ people who have experienced trauma and use alcohol. In the first part, participants share their thoughts to make the program more helpful and inclusive. In the second part, some participants can try th…

This early-stage study tests whether diclofenac, a common anti-inflammatory painkiller, can reduce alcohol cravings in people with Alcohol Use Disorder. Researchers believe diclofenac may work by adjusting brain chemicals linked to alcohol-related behaviors. The study involves 24…

This early-stage study tests whether a new sublingual drug (BXCL501) is safe and shows promise for heavy drinkers who also have PTSD. Ten adults aged 21-65 will take the drug and be monitored for changes in alcohol use, anxiety, and PTSD symptoms over 28 days. The goal is to see …

This study looks at how quitting smoking for six weeks affects the body's chemistry and gut bacteria in people with substance use disorders. Researchers will compare a smoking cessation program to usual care in 100 adults, measuring changes in cravings, mood, and biological marke…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study is testing whether a smartphone app can help young people aged 14 to 35 with alcohol or cocaine use disorder by training their brain to say "no" to substance-related cues. Participants will use the app for short training sessions over a month, plus booster sessions. Th…