ALCOHOL USE DISORDER (AUD)

This study is testing whether doxazosin, a medication typically used for high blood pressure, can help people with alcohol use disorder drink less and have fewer cravings. Researchers will compare the medication against a placebo in 184 adults who want to reduce their alcohol use…

This study is testing whether a smartphone app can help young people (ages 14-35) who are already in treatment for alcohol or cocaine use disorder. The app provides short brain-training games designed to strengthen a person's ability to ignore or resist substance-related cues and…

This study is creating and testing a brief, online therapy program specifically for LGBTQ+ people who have experienced trauma and struggle with alcohol use. In the first part, participants help design the program to make it relevant and affirming. In the second part, some partici…

This is an early safety study to see if a new under-the-tongue film called BXCL501 is safe for people who drink heavily and also have symptoms of PTSD. Ten participants will take the film daily for 28 days while doctors check their blood pressure, anxiety, drinking habits, and ot…

This pilot study is testing whether a combination of medication and counseling is practical, acceptable, and helpful for reducing alcohol use in people living with HIV. The 12-week program involves an existing medication (used 'off-label' for alcohol) along with support from a cl…

This small, early-stage study is testing whether a weekly injection of tirzepatide, a medication currently used for diabetes and weight loss, can help people with alcohol use disorder. Twenty participants will receive either the real medication or a placebo for four weeks to see …

This study is testing if a medication called probenecid can help people with alcohol use disorder. Over 16 weeks, 120 participants will take either probenecid or a placebo pill to see if it reduces their cravings for alcohol and how much they drink. The main goal is to see if thi…

This study is testing if a smartphone app, when used alongside standard medication, helps Veterans with alcohol use disorder reduce heavy drinking days more effectively than medication alone. It will involve 330 Veterans across 15 VA sites who are starting medication treatment. T…

This early-stage study is testing whether diclofenac, an FDA-approved pain and inflammation medication, can help people with alcohol use disorder. Researchers want to see if the drug changes specific brain chemicals linked to alcohol cravings and negative mood. The study will enr…

This study is testing whether a single dose of ketamine, combined with a special brain training session using an MRI scanner, can help people with alcohol use disorder drink less. Researchers will compare the effects of real ketamine and real brain training against placebo and sh…

This early-stage study is testing whether a single dose of the psychedelic substance DMT, combined with psychotherapy, can help people with alcohol use disorder reduce their drinking. Researchers will give 63 participants either DMT or a placebo, along with therapy, to check safe…

This study is investigating whether suvorexant, a medication approved for sleep problems, can change brain chemistry related to addiction in people with alcohol use disorder (AUD). Researchers will compare brain scans, sleep patterns, and cravings in people with AUD receiving eit…

This study aims to see if using a visual life history calendar helps people in Hong Kong remember their mental health history more accurately. Researchers will compare the standard mental health interview with and without the calendar tool. The goal is to improve how we measure h…