Could LSD help curb heavy drinking? new trial investigates

NCT ID NCT05474989

Recruiting now Disease control Sponsor: Felix Mueller Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether moderate to high doses of LSD can reduce heavy drinking in people with alcohol use disorder. 128 participants who have recently detoxified will receive either LSD or a low-dose placebo, along with therapy. The study tracks drinking behavior and brain changes over 30 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LSD (lysergic acid diethylamide)
What this could lead to: If successful, this could provide a new treatment option to help people with alcohol use disorder reduce heavy drinking.
What could go wrong: This is a mid-stage trial with only 128 participants, so results may not apply to everyone. LSD can cause intense psychological effects, and the study is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER (AUD)

Contacts and locations

Locations

University Hospital of Psychiatry, University of Basel
RECRUITING

Basel, Switzerland
University Hospital of Psychiatry, University of Bern
RECRUITING

Bern, Switzerland

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