Could a pill help heavy drinkers cut back? new trial tests mavoglurant

NCT ID NCT06136195

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests whether mavoglurant, a drug taken as a pill, can reduce alcohol cravings and drinking in people who drink heavily. Researchers will give the drug or a placebo to 63 adults with Alcohol Use Disorder and measure how much they drink and crave alcohol. The goal is to see if mavoglurant might help control drinking behavior.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mavoglurant
What this could lead to: If it works, this could point toward a new medication to help heavy drinkers control cravings and reduce alcohol consumption.
What could go wrong: This is a very early Phase 1 trial with only 63 people, so results may not apply widely. The drug may not reduce drinking or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse Alcohol Drinking Alcoholic Intoxication

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL CONSUMPTION ALCOHOL USE DISORDER (AUD) HEAVY DRINKER

Contacts and locations

Locations

Connecticut Mental Health Center (SAC and SATU)
RECRUITING

New Haven, Connecticut, 06511, United States
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06512, United States

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