ALCOHOL USE DISORDER (AUD)

This study tests whether a natural molecule called oleoylethanolamide (OEA) can reduce inflammation, improve thinking, and lower alcohol use in young adults aged 18–25 with alcohol use disorder. Participants will take OEA or a placebo daily for 6 weeks and provide blood, saliva, …

This study looks at whether adding a mobile app to a nurse-led counseling program helps men with alcohol use disorder stay sober longer. About 74 men aged 18-59 who own an Android phone will take part. The goal is to see if the app reduces relapse rates over three months compared…

This Phase 3 trial tests a naltrexone implant placed under the skin to help people with moderate to severe alcohol use disorder drink less. About 240 adults will receive either the implant or a placebo, plus counseling. Researchers will track heavy drinking days over 24 weeks to …

This study tests whether a weekly injection of tirzepatide (a diabetes drug) plus cognitive-behavioral therapy can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking days. 46 participants will receive either the drug or a placebo shot for 8 week…

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

This pilot study will test whether a high-intensity brain stimulation device can help people with alcohol use disorder reduce their cravings and drinking. Eighteen adults will receive 20 sessions of stimulation over 10 days. Researchers will measure changes in cravings, drinking …

This study tests whether internet-based programs can prevent alcohol use disorders in people who are not currently seeking help. About 3,500 adults with risky drinking habits will be randomly assigned to receive online brief advice, unguided online therapy, or guided online thera…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study explores whether listening to music can help young adults (ages 18-35) manage stress during their first year of recovery from alcohol use disorder. Researchers will use a smartphone app and a wearable device to detect stress in real time and suggest calming music. The …

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce alcohol withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care…

This study tests a new tool called SIM-AiR that helps teens (ages 12-19) with alcohol use disorder visually map their social identities and networks. The goal is to support lasting recovery by addressing social risk and protective factors. Researchers will ask teens and their cli…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The…

This study looks at adults in Dorset who visit urgent or emergency care five or more times a year. Researchers will interview patients, carers, and healthcare workers, and analyze data to understand their needs. The goal is to work with the community to design a prevention model …

This study aims to validate a virtual reality version of the Multiple Errands Test for assessing executive functions in people with alcohol use disorder. Ninety participants will complete both a real-world and a virtual supermarket task, along with other cognitive tests. The goal…

This study compares 200 people with alcohol use disorder to healthy volunteers using questionnaires that measure psychological processes and emotional symptoms like depression and anxiety. The goal is to identify differences in how people think and cope. It is purely observationa…