POST-TRAUMATIC STRESS DISORDER (PTSD)

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study compares two treatments for veterans with PTSD who are at high risk for suicide. One group receives Dialectical Behavior Therapy (DBT) plus a special PTSD exposure protocol, while the other gets standard prolonged exposure therapy with suicide risk management. The goal…

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This small early study tests whether a gentle brain stimulation technique called temporal interference (TI) can safely reduce PTSD symptoms in 5 adults. Participants will receive TI stimulation and have their brain activity measured with MRI, MEG, and EEG. The goal is to see if s…

This study tests whether a special computer-based brain training program can help adults with PTSD improve memory, attention, and daily functioning. Participants will be randomly assigned to either the brain training program or regular computer games, both with group discussions,…

This study tests whether transcranial magnetic stimulation (TMS) can help teens aged 12-20 who still have PTSD symptoms after finishing trauma-focused therapy. About 20 participants will receive 10 TMS sessions over a month. The goal is to see if TMS is safe and acceptable, and t…

This study tests whether giving oxytocin nasal spray before couples therapy can help veterans with PTSD feel better and improve their relationships. About 240 veterans and their partners will take part. Half get oxytocin, half get a placebo, and all receive eight sessions of brie…

This study tests a program called NurseNET, where nurses are trained to provide a short-term trauma therapy for PTSD. The goal is to make treatment easier to access for people who see their primary care nurse. Researchers will enroll 100 adults with PTSD symptoms and measure if s…

This study tests a handheld device called gammaCore that gently stimulates the vagus nerve in the neck, aiming to reduce PTSD symptoms. About 40 adults with PTSD will use the device at home for 12 weeks. Researchers will track symptom changes and safety to see if this approach co…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests whether a 2-week, fully remote program combining mild brain stimulation (tDCS) with prolonged exposure therapy can reduce chronic pain and PTSD symptoms. About 146 adults with both conditions will receive either real or sham stimulation alongside therapy, all fro…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This pilot study is testing whether a therapy called EMDR (eye movement desensitization and reprocessing) can help reduce post-traumatic stress and psychological distress in people with advanced thyroid cancer. The study will enroll 25 participants who have cancer and PTSD sympto…

This pilot study tests a new way to deliver trauma-focused therapy to teens with PTSD. It combines therapist-led video sessions with a mobile app for self-paced exercises. Researchers want to see if this blended approach is feasible and acceptable compared to standard therapy. Ab…

This study tests a new form of transcranial magnetic stimulation (TMS) for post-traumatic stress disorder (PTSD). Unlike standard TMS, which takes 6-7 weeks, this accelerated version delivers 10 sessions per day for 5 days. Researchers will enroll 40 adults with PTSD to see if ac…

This study tests a new therapy called the Reconsolidation of Traumatic Memories (RTM) Protocol for people with PTSD in Ukraine. The goal is to reduce distressing symptoms like flashbacks and anxiety without requiring patients to relive their trauma in detail. The study will invol…

This study tests whether 5 group sessions teaching mind-body skills can reduce PTSD symptoms and emotional problems in 120 adolescents aged 11-17 in Gaza who have experienced war-related trauma. Participants are randomly assigned to either the mind-body group or a control group, …

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

This study tests a software program designed to reduce symptoms of post-traumatic stress disorder (PTSD). About 52 adults with PTSD will use the software or a placebo version. Researchers will measure changes in PTSD severity using a standard scale over the study period.

This early-phase study tests whether a sublingual form of dexmedetomidine (BXCL501) is safe and shows promise for treating alcohol use disorder in people who also have PTSD. Ten heavy drinkers with PTSD will take the drug and be monitored for changes in blood pressure, anxiety, a…

This study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …

This study tests whether brief educational videos delivered by text message can help young people aged 15-25 manage symptoms of post-traumatic stress disorder (PTSD). Participants are randomly assigned to receive the videos right away or after a 5-month wait. The study is fully o…

This study looks at how a stellate ganglion block injection affects sleep in U.S. service members and veterans with PTSD who are already receiving talk therapy. About 40 participants will wear an EEG headband for three nights before and three nights after the injection to measure…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…