Could a single dose of ketamine during surgery cut opioid use and PTSD?
NCT ID NCT06903819
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will be randomly assigned to receive either ketamine or standard anesthesia, and will be followed for six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine
What this could lead to
If it works, this could offer a way to reduce opioid use and improve mental health recovery after serious orthopedic surgery.
What could go wrong
This is a small, early-phase trial with only 90 participants. Ketamine may not reduce pain or opioid use more than standard care, and it can cause side effects like hallucinations or nausea.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Texas Tech University Health Sciences Center Lubbock
RECRUITINGLubbock, Texas, 79415, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Medical Center
RECRUITINGLubbock, Texas, 79415, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact