Could a single dose of ketamine during surgery cut opioid use and PTSD?

NCT ID NCT06903819

Recruiting now Symptom relief Sponsor: Texas Tech University Health Sciences Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will be randomly assigned to receive either ketamine or standard anesthesia, and will be followed for six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine
What this could lead to: If it works, this could offer a way to reduce opioid use and improve mental health recovery after serious orthopedic surgery.
What could go wrong: This is a small, early-phase trial with only 90 participants. Ketamine may not reduce pain or opioid use more than standard care, and it can cause side effects like hallucinations or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder injury opioid abuse Pain, Postoperative post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION OPIOID USE ORTHOPEDIC TRAUMA SURGERY PATIENTS POST TRAUMATIC STRESS DISORDER (PTSD) POSTOPERATIVE PAIN

Contacts and locations

Locations

Texas Tech University Health Sciences Center Lubbock
RECRUITING

Lubbock, Texas, 79415, United States
University Medical Center
RECRUITING

Lubbock, Texas, 79415, United States

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