POSTOPERATIVE PAIN

This study aims to see which of two dental pastes causes less pain for patients between root canal treatment visits. Sixty healthy adults needing a root canal re-treatment will have either a traditional paste (calcium hydroxide) or a newer paste (Bio-C Temp) placed in their tooth…

This study aims to see if giving morphine during heart bypass surgery helps reduce pain in the first day after the operation. It will involve 60 patients who are randomly assigned to either receive extra morphine during surgery or continue with standard pain control. Researchers …

This study compares two different nerve block techniques for managing pain after laparoscopic stomach cancer surgery. Researchers want to see if a newer nerve block method works as well as the current standard approach at reducing pain and the need for opioid pain medications. Th…

This study is testing if two simple actions—getting out of bed early and drinking coffee—can help women feel better after a C-section. Researchers want to see if this approach reduces pain from gas, helps the bowels start working again, and improves mood. The study will involve 6…

This study aims to find out which of two common ointments works better to reduce pain after hemorrhoid removal surgery. Researchers will compare a numbing cream (lignocaine) with a blood-flow cream (glyceryl trinitrate) in 64 patients. The main goal is to see which ointment provi…

This study is testing whether an intravenous infusion of the hormone oxytocin can help reduce pain and the need for opioid painkillers after a minimally invasive hysterectomy. 152 women will be randomly assigned to receive either oxytocin or a placebo (saltwater) infusion during …

This study is testing whether a specific nerve block, given before surgery, can better control pain and reduce the need for opioid painkillers after breast implant surgery. It will compare two groups of 40 patients: one receiving the nerve block and one receiving standard care. T…

This study is testing whether a local anesthetic injection given during surgery can reduce pain in the first day after a minimally invasive procedure for pelvic organ prolapse. 58 women having this specific surgery will be randomly assigned to receive either the pain-blocking inj…

This study is testing whether virtual reality (VR) relaxation sessions can help people recover better after major abdominal surgery. Patients will use VR headsets with guided relaxation programs before and after their operation to see if it reduces pain, anxiety, and how long the…

This study is testing if a targeted numbing injection, given before heart surgery, can reduce the amount of strong opioid painkillers needed during the operation. Researchers will compare 80 adults getting the injection plus standard anesthesia to those getting standard anesthesi…

This study compares two different nerve block techniques to manage pain after hip replacement surgery for hip fractures. Researchers want to see which method provides better pain relief while preserving leg muscle strength to help patients move sooner. The study involves 80 elder…

This study compares two different nerve block techniques to see which provides better pain relief after breast reduction surgery. Researchers will enroll 90 women having this surgery and randomly assign them to receive one of two ultrasound-guided nerve blocks before their operat…

This study is testing if a simple, non-invasive device called TENS can help people feel better before and after gallbladder removal surgery. TENS uses mild electrical currents on the skin to stimulate nerves. Researchers will compare 80 patients who receive TENS along with standa…

This study is testing if a natural extract from horse chestnut (called Reparil) works as well as ibuprofen to manage pain, swelling, and jaw stiffness after wisdom tooth surgery. One hundred healthy adults will take either the herbal extract or ibuprofen for five days after their…

This study is comparing two different nerve-block techniques to see which one better controls pain after minimally invasive stomach cancer surgery. Researchers are testing a newer method (EOIB) against a more established one (ESPB) to see if it works just as well. The goal is to …

This study aims to find out which of two common pain medications given during gallbladder surgery helps patients recover faster. Researchers will compare fentanyl and remifentanil in 106 patients to see which leads to quicker return of normal bowel function and better pain contro…

This study is testing whether a combination of virtual reality (VR) and pleasant scents can help reduce pain and anxiety for people recovering from major heart or lung surgery. The goal is to see if this drug-free approach can be a practical alternative to strong pain medications…

This study is testing whether a simple numbing injection given around the cervix during vaginal hysterectomy surgery helps patients use fewer strong opioid painkillers afterward. Researchers will compare 56 patients who receive the numbing medicine to those who receive a placebo …

This study is testing if a mouthwash made with tea tree oil works as well as a standard chlorhexidine mouthwash to help people heal after having a wisdom tooth pulled. Researchers will compare how well each mouthwash reduces pain, facial swelling, and jaw stiffness over 7 days in…

This study is looking at the best time to give a numbing injection to help control pain after keyhole gallbladder surgery. Patients will be randomly chosen to get the injection either right before the surgery starts or right after it finishes. Researchers will then compare how mu…

This study is testing a new type of nerve block, called EXORA, to see if it works as well as or better than a common nerve block for managing pain after gallbladder removal surgery. Researchers will compare pain levels and opioid painkiller use in patients who receive one of the …

This study is testing a new pain-relief technique for people who donate part of their liver. It compares a targeted nerve-block injection to standard pain medication after surgery. The goal is to see if the new method reduces overall pain and the need for strong opioid painkiller…

This large study aims to find out if adding a very small dose of morphine to the standard spinal anesthesia for a planned C-section can provide better pain relief afterward. It will compare the morphine to a placebo (saltwater) in over 1,300 mothers to see if it safely reduces pa…

This study compares two ways to manage pain after elective lower back surgery. Patients will receive either an ultrasound-guided nerve block or standard intravenous pain medications. Researchers will use a special monitor that measures heart rate patterns to objectively assess pa…

This study compares two different nerve-blocking techniques to see which one better controls pain after surgery for undescended testicles in young boys. It involves 70 children aged 1 to 7 years. Doctors will use ultrasound to guide the injection of a numbing medicine and then me…

This study aims to find the best way to reduce pain after minimally invasive gynecologic surgery. Researchers will observe 86 patients to compare two established nerve-block techniques: one targets the front abdominal wall, while the other combines that with a block for the side.…

This study compares two methods for managing pain after minimally invasive surgery to correct pectus excavatum (a sunken chest). Researchers will test whether freezing the nerves between ribs (cryoanalgesia) works as well as or better than a traditional epidural pain block. The t…

This study is testing whether a specific type of breathing exercise, called pranayama, can help reduce pain and improve comfort for women recovering from a planned cesarean section. It will involve 100 women who have just had a C-section and are experiencing significant pain. The…

This study is testing whether a short hypnosis session before abdominal surgery can help reduce patients' anxiety and pain afterwards. About 48-68 adults scheduled for surgery in Morocco will be randomly assigned to receive either a 15-20 minute hypnosis session or standard psych…

This study is testing whether a low dose of the drug ketamine can help reduce pain and the need for strong opioid painkillers after major aortic surgery. It will involve 30 patients who are having a specific type of aortic repair and receiving a protective spinal cord infusion th…

This study is testing if a targeted numbing injection, given during surgery, can better control pain and reduce the need for strong opioid painkillers after kidney donation. Fifty people donating a kidney will be randomly assigned to receive either the standard anesthesia or the …

This study aims to find the best way to manage pain for young boys (aged 1-7) after hypospadias surgery. It compares two different numbing injections given during the operation to see which one provides better and longer-lasting pain relief after they wake up. The main goal is to…

This study aims to find the best single dose of a pain medication called tegileridine for adults recovering from bone or joint surgery. Researchers will test different doses in 180 patients to see which one effectively controls pain for 90% of people shortly after waking up from …

This study is testing if giving a single dose of ketamine during surgery helps adults with serious bone injuries recover better. Researchers want to see if ketamine reduces pain after surgery, lowers the need for strong opioid painkillers, and improves symptoms of depression and …

This study aims to find the best way to manage pain after breast cancer surgery. Researchers are comparing two different nerve-blocking injections given before surgery to see which one better controls pain and reduces the need for strong opioid painkillers like morphine. The tria…

This study is testing two different ways to deliver anesthesia during brain surgery to see which one leads to better recovery. It will compare a computer-controlled method with a manual method in 70 patients. The main goal is to see if one method lowers the risk of post-surgery c…

This study aims to find the best way to manage pain after open-heart surgery. It will compare two different nerve-block techniques, where medication is injected near nerves to numb the chest area. The goal is to see which method provides better pain relief with less need for stro…

This study is testing which dose of a steroid medicine works better to reduce pain after getting a dental implant. About 138 adults will get either a 4mg injection, an 8mg injection, or a placebo (saltwater) shot at the surgery site. Researchers will track their pain levels and h…

This study is testing a new, long-acting pain medication called TLC590 for people having bunion surgery. Researchers want to see if a single injection of TLC590 at the surgery site works better and lasts longer than the current standard treatment or a placebo (saltwater shot). Th…

This study compares different nerve block techniques for pain relief after shoulder surgery. Researchers want to see if newer methods can provide good pain control while avoiding the breathing problems sometimes caused by the current standard block. They will measure pain levels …

This study aims to see if a specific nerve block (paravertebral block) is better than standard pain medication at reducing pain after mastectomy with immediate reconstruction. Researchers will enroll 60 women to compare pain levels and opioid use in the first 72 hours after surge…

This small pilot study is testing whether a free mindfulness app can help reduce anxiety for people waiting for elective surgery. Researchers will compare 40 patients who use the app for four weeks before their operation to those who receive standard care alone. The main goal is …

This study is testing a new type of nerve block to help control pain after laparoscopic gallbladder removal surgery. Researchers will compare pain levels and medication use in 60 patients who receive the new block versus standard pain control. The goal is to see if this method pr…

This study is observing whether a specific nerve block, given with ultrasound guidance, helps control pain after lumbar spine surgery. It will follow 60 adult patients to see if this block, used alongside standard pain medication, leads to less pain, lower opioid use, and fewer s…

This study is testing whether giving a combination of two existing drugs (lidocaine and dexmedetomidine) during weight-loss surgery can better reduce pain, inflammation, and body stress in the first day after the operation. Researchers will compare the combination against each dr…

This study is testing whether injecting a local numbing medicine (bupivacaine) into the small incision sites and the top of the vagina at the end of a laparoscopic hysterectomy helps reduce pain after surgery. About 120 women having this surgery for non-cancerous conditions will …

This study compares two different nerve-blocking techniques to manage pain after heart surgery through the breastbone. Researchers will test which method provides better pain relief and recovery for 50 patients undergoing this type of surgery. The goal is to improve comfort and r…

This study aims to find the best way to manage pain after hip surgery. Researchers are comparing two established methods: a nerve block injection in the groin area and a pain medication given into the spinal fluid. They will measure which one provides longer-lasting pain relief b…

This study is testing if applying a special gel called RADA16 during tonsil removal surgery helps patients recover better. Researchers want to see if the gel reduces pain, bleeding, and the need for strong painkillers after the operation. About 134 adults having a tonsillectomy w…

This study is testing a new type of nerve block, called the Quadro-Iliac plane block, to see if it improves recovery and reduces pain after laparoscopic inguinal hernia surgery. Researchers will compare this new block to standard pain management in 70 adults having this common op…

This study is testing whether a targeted nerve block, given during surgery, can reduce pain and help people recover faster after a common type of hernia repair. It will involve 100 adults having a specific, minimally invasive hernia operation. Half will receive the nerve block, a…

This study is comparing two different nerve block techniques to see which one better controls pain and reduces the need for opioid painkillers during and after chest surgery. Researchers will use a special finger monitor to measure patients' pain levels more accurately during the…

This study is testing whether melatonin (a natural sleep hormone) or pregabalin (a prescription nerve pain medication) works better to reduce pain and anxiety after spine surgery. Researchers will give one of these pills to 105 adults having elective spine surgery and measure the…

This study aims to see how a long-acting numbing medicine called EXPAREL works in the body and how safe it is for children under 6 years old who are having heart surgery. It will be compared to a standard numbing medicine, bupivacaine. The goal is to find a safe and effective way…

This study is testing if a combination of a lidocaine spray applied inside the abdomen during surgery and lidocaine given through an IV can better control pain after laparoscopic fibroid removal. It aims to see if this approach reduces moderate-to-severe pain in the first 24 hour…

This study is testing a new, targeted nerve block to manage pain after major spinal fusion surgery. Researchers will give the ultrasound-guided block to some patients to see if it reduces their need for opioid painkillers and helps them recover faster. The goal is to find a safer…

This study aims to find the best timing for a pain-relieving nerve block in patients having surgery for a slipped disc in the lower back. Researchers will compare giving the block before surgery starts versus during the operation. The main goal is to see which timing leads to les…

This study is testing if a specific nerve block, given after heart surgery, can help control pain better. Researchers want to see if it reduces the need for strong opioid painkillers and lowers patients' pain scores. The study will involve 75 adults having planned heart surgery, …

This study compares two different ways to control pain after laparoscopic kidney donation surgery. Researchers want to see which method helps patients breathe better by reducing pain that makes people take shallow breaths. Eighty patients will be randomly assigned to receive eith…

This study is testing if a new type of ultrasound-guided nerve block can improve recovery and reduce pain after a specific kind of heart bypass surgery. Researchers will compare 60 patients who receive the nerve block before surgery to those who receive standard pain care. The ma…

This study is testing whether giving the drug ketamine before surgery can better control pain after a common weight loss procedure called laparoscopic sleeve gastrectomy. Researchers will compare ketamine against a standard pain control method in 90 patients. The main goal is to …

This study is testing whether a specific nerve block, given at the end of liver transplant surgery, helps control pain better during recovery. Researchers will compare 60 patients who receive the block to those who do not, measuring how much strong pain medication they need and t…

This study is testing whether having patients fill out a daily pain diary helps doctors understand their pain better after gallbladder removal surgery. Researchers will compare the diary method to the standard way nurses ask about pain. The goal is to improve how pain is tracked …

This study aims to understand if a parent's confidence in supporting their child's independence is linked to how much pain the child feels after minor surgery. Researchers will observe 150 children (ages 3-18) and their parents at a hospital in Turkey. Parents will fill out a sur…

This study aims to understand why some people experience more pain after surgery than others. Researchers will observe 5,000 adults having elective surgery to see if their genes, along with other factors, are linked to severe pain, high painkiller use, or long-term pain. The goal…

This study aims to understand why some people experience more pain than others after a common dental procedure where a small piece of gum tissue is taken from the roof of the mouth. Researchers will follow 93 patients having this surgery, collecting detailed information about the…

This study is testing a new, non-invasive device that measures changes in a child's pupil size to try to get an objective reading of their pain. It involves 100 children and teens, aged 6 to 21, who are having planned surgery or a bone marrow transplant at Children's National Hos…

This study aims to understand if severe pain experienced just before emergency surgery increases the risk of developing long-term chronic pain after the operation. Researchers will follow 693 adults undergoing emergency bone or abdominal surgery in France. The goal is to identify…

This study aims to understand if a child's anxiety level right before surgery can predict how much pain and confusion they experience after waking up. Researchers will observe 60 boys, aged 2 to 7, undergoing common urogenital surgeries. They will measure anxiety before the proce…