POSTOPERATIVE PAIN

This study tests a dental implant technique for people with a narrow jawbone (narrow alveolar ridge). The procedure involves splitting the ridge and placing an implant covered with a special growth factor membrane. Ten adults aged 20-50 will be evaluated for pain, tissue thicknes…

This study tests whether rinsing with hydrogen water can reduce mouth inflammation, pain, and improve healing in 36 adults after oral cancer surgery with free flap reconstruction. Participants will use hydrogen water mouth care for 7 days, and researchers will measure changes in …

This study looks at whether listening to music and using Emotional Freedom Techniques (a type of tapping therapy) can help people recover more smoothly after knee arthroscopy. The goal is to see if these simple, safe methods can reduce pain, fear of moving, and the risk of fallin…

This study tests whether a single injection of dexamethasone given before removing an impacted lower wisdom tooth can lessen pain and difficulty opening the mouth afterward. 268 adults aged 18 to 55 will be randomly assigned to receive either the steroid or no extra medication. P…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults will be randomly assigned to receive either the real stimulation or a sham (fake) versio…

This study tests if a special nerve block (external oblique intercostal block) can reduce pain and the need for strong painkillers after gallbladder removal surgery. About 56 adults having planned laparoscopic cholecystectomy will be randomly assigned to get the block or not. The…

This study compares two types of nerve blocks to control pain after laparoscopic sleeve gastrectomy (weight-loss surgery). Sixty adults will receive either an intertransverse process block or a subcostal transversus abdominis plane block. The goal is to see which method provides …

This study looks at whether using a vibrating device or doing breathing exercises right before a chest tube is taken out can help lower pain and anxiety. About 70 adults who need a chest tube removed after surgery will be split into three groups: vibration, breathing exercises, o…

This study tests whether a small device called TENS, which sends mild electrical pulses through the skin, can help reduce pain and improve sleep after inguinal hernia surgery. About 80 adults will either receive TENS or standard care after their operation. Researchers will measur…

This study compares two ultrasound-guided nerve blocks—transversalis fascia plane block and erector spinae plane block—for pain relief after cesarean section. Sixty women having a planned C-section will receive one of the two blocks, and researchers will measure pain scores and h…

This study compares two types of nerve blocks to see which better controls pain after open ventral hernia repair. Fifty adults will receive one of the two blocks before surgery, and researchers will measure how much extra pain medicine they need in the first 24 hours. The goal is…

This study compares two common ultrasound-guided nerve block techniques to see which one helps patients recover better after keyhole gallbladder removal. 76 adults having elective surgery will receive one of the two blocks while asleep. The main goal is to measure recovery qualit…

This study looks at the best time to give a painkiller called Anrikefon to adults having gallbladder surgery. About 274 people will get the drug either before anesthesia or right after the gallbladder is removed. The goal is to see which timing reduces pain better and helps patie…

This study compares two numbing techniques—RIB and PVB—to control pain after chest surgery. 60 adults having a specific type of keyhole chest surgery will be randomly assigned to one of the two blocks. Pain levels and side effects will be tracked for 24 hours after surgery to see…

This study tests two methods—scalp nerve blocks and a sedative drug called dexmedetomidine—to see if they can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having elective brain surgery will be randomly assigned t…

This study tests whether an experimental drug called CPL-01 can reduce pain after bunion surgery. About 112 adults having bunion repair will receive either CPL-01 or a placebo. Researchers will measure pain levels and how much extra pain medicine participants need.

This study tests whether rinsing the belly with salt water during a scarless hysterectomy (vNOTES) can lower pain after surgery. About 94 women having the procedure will be randomly assigned to get the rinse or not. The goal is to see if this simple step reduces discomfort and he…

This study compares two common root canal cleaning solutions—chlorhexidine and sodium hypochlorite (bleach)—to see which one leads to less pain the day after the procedure. About 90 adults needing a root canal will be randomly assigned to one of the two solutions. Participants wi…

This study looks at whether adding a common anti-inflammatory drug (dexamethasone) to a standard pain medicine (dexmedetomidine) can help people feel less pain after shoulder surgery. About 70 adults having shoulder arthroscopy will get a nerve block and either the drug combo or …

This study compares two types of nerve blocks (iPACK and BiFeS) to see which one provides better pain relief after total knee replacement. About 100 adults scheduled for surgery will receive one of the two blocks, and researchers will measure pain levels, opioid use, and how quic…

This study compares two types of nerve blocks (M-TAPA and ESPB) to see which provides better pain relief after laparoscopic gallbladder removal. About 124 adults having elective surgery will be randomly assigned to receive one of the blocks. The main goal is to measure how much o…

This study compares two types of nerve blocks to see which provides better pain relief after open gallbladder removal. Sixty-six adults having this surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure pain levels two hours after surgery,…

This study compares two types of nerve blocks used to manage pain after mastectomy (breast removal surgery). The goal is to see which block is easier for doctors to perform and which provides better comfort for patients. About 64 adults scheduled for mastectomy will take part. Th…

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can help reduce pain and anxiety after breast surgery. About 126 adults having their first mastectomy will be randomly assigned to one of the breathing groups or to standard care. They wi…

This study tests whether using a special vibration tool after wrist fracture surgery can improve pain control and reduce the need for opioid painkillers. About 100 adults who have had surgery for a broken wrist will use the device and report their pain levels and medication use. …

This study compares two natural herbal medications (propolis and green tea extract) against the standard calcium hydroxide paste for reducing pain and sudden flare-ups after root canal retreatment. Forty adults with a failed root canal in a single-rooted tooth will receive one of…

This study looks at whether taking acetaminophen (Tylenol) by mouth or through an IV works better for pain after lower back fusion surgery. About 180 adults having 1-3 level lumbar fusion will be randomly assigned to one of the two methods for 48 hours after surgery. Researchers …

This study tests whether adding electroacupuncture to standard numbing medicine can reduce pain and stress during wisdom tooth surgery. Sixty adults aged 25-35 will be randomly assigned to receive real electroacupuncture, sham acupuncture, or no extra treatment. Researchers will …

This study tests if a special nerve block (SPSIP block) works better than standard numbing medicine for reducing pain during port catheter placement. About 70 adults having this procedure will be randomly assigned to one of the two methods. The goal is to find a more comfortable …

This study tests whether adding a nerve block to the back of the hip to two standard blocks can improve pain relief after hip surgery. 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine. The goal is to reduce pai…

This study compares two common pain relief techniques—local anesthetic injection and ultrasound-guided nerve block—for people having gallbladder removal surgery. The goal is to see which method better reduces pain and the need for strong painkillers. Sixty adults aged 18 to 65 wi…

This study looks at whether a simple breathing exercise called box breathing can help older adults (65+) recover from knee replacement surgery. The goal is to see if it reduces stress, pain, anxiety, and improves overall recovery. Thirty-two participants will either practice box …

This study tests if a surgeon can numb the knee during surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see which approach provides better pain relief and recovery.

This study compares two types of nerve blocks (QIPB and SIFICB) to see which one controls pain better after hip surgery. About 60 adults having hip surgery will be given one of the two blocks, and their pain levels and need for extra pain medicine will be tracked. The goal is to …

This study compares two types of nerve blocks to control pain after video-assisted lung surgery. Sixty adults will receive one of the two blocks, and researchers will measure pain levels, opioid use, and side effects over the first 24 hours. The goal is to find which block provid…

This study tests a new type of nerve block (SPSIPB) to see if it can reduce pain and the need for strong painkillers after heart surgery. About 120 adults having planned heart surgery through a chest incision will be randomly assigned to get either the nerve block or standard car…

This study tests whether injecting tramadol (a painkiller) into the knee joint after arthroscopic knee surgery can reduce pain. 135 adults having minor knee surgery will be randomly assigned to receive either tramadol, tramadol plus dexamethasone, or a placebo injection. The main…

This study tests if a common medicine, magnesium, can reduce pain after a C-section. 150 women having planned or non-urgent C-sections will receive either magnesium or a saltwater drip after delivery. Neither they nor their doctors will know which they got. Pain, recovery, and bo…

This study looks at 50 adults having knee replacement surgery to see which type of anesthesia works best for pain and reduces the need for painkillers in the first two days after surgery. Participants will receive either general anesthesia with a nerve block, spinal anesthesia wi…

This study tests whether a cold anti-inflammatory rinse (ketorolac tromethamine at 2-5°C) placed inside the tooth after root canal treatment can lower post-procedure pain compared to the same rinse at room temperature. Sixty adults with painful tooth infections will rate their pa…

This early-stage trial tests whether KHN702 tablets can safely ease moderate to severe pain after surgery. About 24 adults will receive either the drug or a placebo, and researchers will measure pain relief over 48 hours. The goal is to see if this new pill works and is safe enou…

This study compares two types of nerve blocks (SAP and SPSIP) to see which provides better pain relief after breast surgery (mammoplasty). Sixty women aged 18-85 will be randomly assigned to receive one of the blocks. Researchers will measure pain scores, opioid use, and patient …

This study tests two different nerve blocks to see which one provides better pain relief after breast cancer surgery that also removes lymph nodes from the armpit. About 60 women having this surgery will be randomly assigned to receive one of the two blocks. The goal is to find w…

This study tests a new type of nerve block (called revised-PVB) to see if it reduces pain and helps people recover faster after gallbladder removal surgery. About 250 adults having this surgery will either get the new block or standard care. The goal is to improve comfort and qua…

This study tests whether a special nerve block called M-TAPA can reduce pain and the need for strong painkillers after laparoscopic hysterectomy. About 60 adults having this surgery will be randomly assigned to receive either the nerve block or standard pain care. The main goal i…

This study tests whether a special nerve block called M-TAPA can reduce pain and the need for strong painkillers after open-heart surgery. About 80 adults having elective open-heart surgery will receive either the nerve block plus standard care or standard care alone. The goal is…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40-70 who are having this surgery will choose whether to use the pillow. Their pain, sleep quality, and shoulder functio…

This study tests whether giving a single dose of methadone at the start of surgery can provide better pain relief and faster recovery compared to standard short-acting opioids. About 400 adults having intermediate-risk noncardiac surgery will take part. The main goal is to see if…

This study tests a new type of nerve block (called revised paravertebral block) to see if it reduces pain and helps patients recover faster after stoma closure surgery. About 250 adults having elective stoma reversal will receive either the new block or standard care. The main go…

This study tests whether a special nerve block (ESP block) can better control pain after back surgery. 75 adults having spinal fusion will receive either a standard numbing medicine or one with a longer-acting version. Researchers will measure pain levels, opioid use, and how qui…

This study tests if spraying a numbing medicine (bupivacaine with epinephrine) over the diaphragm can reduce shoulder pain after laparoscopic gynecologic surgery. About 100 women will receive either the numbing spray or a saltwater spray during surgery. Researchers will compare p…

This study tests whether a gel called RADA16 can help children aged 3 to 17 recover better after having their tonsils removed. About 134 children will either get the gel applied during surgery or not. Researchers will track pain and bleeding for 30 days after the procedure.

This study tests whether adding a second nerve block to the standard one can better control pain after hip replacement surgery. Forty adults having hip replacement will be randomly assigned to receive either the standard block or the standard plus an extra block. Researchers will…

This study compares two common nerve block techniques for shoulder surgery to see which provides better pain control with fewer side effects. About 60 adults having arthroscopic shoulder surgery will receive either an interscalene block alone or a combined interscalene and supras…

This early-stage study tests a new medicine called SYH9089 for pain after abdominal surgery. About 60 adults will receive either the new drug, an active painkiller, or a placebo. Researchers will check how safe the drug is and how well it controls pain in the first few days after…

This early-stage trial will test whether a single dose of psilocybin (the active ingredient in magic mushrooms) is safe and practical for adults with opioid use disorder who are recovering from trauma surgery. Seventy participants will receive the drug during their hospital stay …

This study tests a new type of nerve block (External Oblique Intercostal Plane Block) to see if it reduces pain and the need for strong painkillers after major upper abdominal surgery. About 78 adults having laparoscopic surgery on their stomach, liver, gallbladder, or pancreas w…

This study tests a combination of pain medicines and local numbing to improve pain control after brain tumor surgery. The goal is to reduce the need for strong opioids, which can cause side effects and complications. About 2,000 adults having planned brain surgery will take part.…

This study compares a new nerve block (PENG) to standard spinal morphine for pain after total hip replacement. 180 adults undergoing hip surgery will receive one of the two methods. The goal is to see which provides better pain control with fewer side effects like nausea and itch…

This study tests two methods to reduce pain after keyhole stomach cancer surgery. One group gets a standard ultrasound-guided nerve block, while the other gets a special gel applied directly to the surgical site. The goal is to see which approach provides better pain relief and h…

This study compares two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective way…

This study looks at whether a hot water foot bath can reduce pain and help people pass gas sooner after laparoscopic gallbladder removal. About 62 adults who have pain after surgery will be randomly assigned to get the foot bath or standard care. The goal is to find a simple, dru…

This study looks at whether a special nerve block given during left-sided colorectal surgery can better control pain and reduce the need for opioids. About 400 adults having minimally invasive surgery will be observed. The goal is to see if this approach leads to less pain, less …

This study compares two ultrasound-guided pain-blocking techniques for adults having open-heart surgery. The goal is to see which method better reduces the need for strong painkillers (opioids) in the first 24 hours after surgery. 80 participants will be randomly assigned to rece…

This study tests two different medicines (dexmedetomidine and low-dose ketamine) to see which one works better for pain control during and after weight-loss surgery. The goal is to reduce the need for strong opioid painkillers like morphine. 90 adults having bariatric surgery wil…

This study is comparing two methods to manage pain after a common children's ear surgery. Researchers want to see if a targeted numbing shot near the ear (Nerve of Arnold block) works as well as the standard pain shots, which include an opioid. The goal is to find a way to contro…

This study looks at whether the position you are in when you get a nerve block for chest surgery changes how well it works. 90 adults having video-assisted chest surgery will be randomly placed in either a sitting or lying-on-the-side position for the block. Researchers will meas…

This study looks at whether a skin sensor can continuously measure pain in newborns after surgery. Since babies can't tell us they're in pain, doctors currently rely on checklists and vital signs. The sensor tracks stress signals through the skin, offering a more objective way to…

This study will check if measuring belly muscle thickness with ultrasound before surgery can help predict how much pain medicine older patients need after abdominal surgery. Researchers will track pain scores and opioid use in 62 patients aged 65 and older during the first 24 hou…

This study will observe 250 children aged 2 to 8 who are having urogenital surgery. Researchers want to see if the length of time they fast before surgery affects their pain and agitation after the procedure. The goal is to find the best fasting time to improve recovery for child…

This study watches anesthesia residents as they place epidural catheters in 440 patients having surgery. It compares two common techniques—loss of resistance and hanging drop—to see which one succeeds more often on the first try and causes fewer problems like accidental dural pun…

This study looks at how a new pain medicine called Anrikefon works in people aged 65 and older after laparoscopic (keyhole) belly surgery. Thirty participants will receive the drug at set times and have their blood tested to measure drug levels. The goal is to understand how the …

This study looks at 100 adults having their thyroid gland removed to see how different pain relief methods affect recovery and swallowing pain. Researchers will observe patients under normal care without giving any new treatments. The goal is to learn which approach leads to bett…

This study looks at 100 adults having gallbladder removal to see if the pain from getting an IV and their anxiety before surgery can predict how much pain they will have afterward. Researchers will measure pain and anxiety with simple questionnaires and track pain levels for 12 h…

This study involves 14-18 healthy volunteers who will receive three different types of quadratus lumborum blocks on separate days. The goal is to compare how each block affects skin sensation and leg strength. Results will help doctors choose the best approach for managing pain a…

This study will follow 150 adults with war-related injuries to see if using negative pressure wound therapy (a vacuum dressing) is linked to persistent pain six months later. Researchers will also track other factors like pain intensity and number of surgeries. The goal is to hel…

This study looks back at medical records of 66 women who had a mastectomy to see which pain relief method worked best. It compares standard pain medication, a nerve block called rhomboid intercostal block (RIB), and a combination of RIB with another nerve block. The goal is to fi…