POSTOPERATIVE PAIN

This study tests a dental procedure for people with narrow jawbones who need implants. Surgeons split the ridge, place the implant, and cover it with a membrane made from the patient's own blood (concentrated growth factor) to help healing. Ten adults aged 20-50 will be followed …

This trial tests whether a brief virtual reality (VR) session before gynecological surgery can lower anxiety and improve recovery. About 140 adults will be randomly assigned to either a 10-20 minute VR relaxation experience plus standard care, or standard care alone. Researchers …

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This study will compare two types of nerve blocks for pain relief after shoulder surgery. One is a standard block that can sometimes weaken breathing; the other is a newer block that may avoid that side effect. 120 adults having shoulder arthroscopy will be randomly assigned to o…

This trial compares two types of nerve blocks given before breast surgery to see which better prevents chronic pain that can last for months. Women aged 18-65 scheduled for mastectomy will receive either a serratus posterior superior intercostal plane block or an erector spinae p…

This study tests whether a specific nerve block, called the rectointercostal plane block (RICPB), can reduce pain and the need for strong painkillers after gallbladder removal surgery. Sixty adults scheduled for laparoscopic cholecystectomy will receive either the RICPB or standa…

This study compares two drugs, ketamine and fentanyl, added to a standard numbing medicine (bupivacaine) to control pain after laparoscopic gallbladder removal. 84 adults aged 20-50 will receive one of the two combinations during surgery. The goal is to see which provides longer-…

This study tests a nerve block called PENG (pericapsular nerve group block) to see if it can reduce pain and the need for painkillers after shoulder surgery. Sixty adults having arthroscopic shoulder surgery will receive the block with one of two different volumes of anesthetic. …

This study tests whether a specific nerve block (ESP block) using bupivacaine can reduce pain and opioid use after spinal fusion surgery. 75 adults undergoing cervical or lumbar fusion will be randomly assigned to receive either plain bupivacaine or a mix with liposomal bupivacai…

This study looks at whether giving a nerve block (serratus anterior plane block) before or after mastectomy surgery leads to better recovery and less pain. Eighty women having a mastectomy will be randomly assigned to receive the block either before the surgeon makes the first cu…

This study will compare two types of nerve blocks (M-TAPA and ESP block) to see which provides better pain relief after laparoscopic sleeve gastrectomy. Sixty-four patients will receive an injection of the numbing medicine bupivacaine in one of the two block techniques. Pain scor…

This study tests whether a single injection of a slow-release painkiller (liposomal bupivacaine) into a nerve block can control pain for up to 72 hours after hip fracture surgery in older adults. The standard drug only lasts about 12 hours, often leading to more pain and opioid u…

This study compares two types of nerve blocks—Intertransverse Process Block and M-TAPA—for pain after laparoscopic gallbladder removal. Sixty adults will be randomly assigned to receive one of the blocks. The main goal is to see which block provides better pain relief and reduces…

This study tests whether placing a loxoprofen sodium patch on the skin before video-assisted lung surgery can reduce pain and the need for strong painkillers afterward. About 156 adults aged 18 to 64 having lung surgery will be randomly assigned to get the patch or a placebo. The…

This study tests whether a newer painkiller, tegileridine, can control pain after major laparoscopic abdominal surgery as well as the standard drug sufentanil, but with fewer gastrointestinal side effects like nausea or constipation. About 84 adults having elective major abdomina…

This study tests whether applying a mix of local anesthetics and blood-clotting drugs directly into surgical wounds during hand surgery can reduce pain and the need for opioid painkillers afterward. Forty adults having elective hand surgery will be randomly assigned to one of fou…

This study looks at whether giving midazolam before surgery or during anesthesia works better for children having their tonsils removed. One hundred kids aged 3-10 will be randomly assigned to receive the drug either as a drink 30 minutes before surgery or through an IV during an…

This study tests a technique called cryoablation, where doctors temporarily freeze nerves in the chest during open-heart surgery. The goal is to see if this reduces pain, helps patients breathe deeper and cough better after surgery, and lowers the need for strong painkillers like…

This study tests whether a combination of two drugs, dexmedetomidine and ketamine, can replace opioids for pain control during kidney stone surgery. Sixty adults undergoing the procedure will receive either the opioid-free combo or standard fentanyl-based anesthesia. Researchers …

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

This study compares two different volumes of the same painkiller (bupivacaine) given as a TAP block after cesarean section. The goal is to see if a larger volume provides better pain relief without increasing side effects. Fifty full-term mothers having planned C-sections will ta…

This study compares a new under-the-tongue painkiller (sublingual sufentanil) to standard morphine pills for managing pain after surgery. The goal is to see if the new drug helps patients recover their health faster. About 1150 adults having surgery will take part, receiving eith…

This study will compare two types of nerve blocks—Transversalis Fascia Plane Block and M-TAPA—for controlling pain after laparoscopic inguinal hernia repair. Sixty adults aged 18–65 will be randomly assigned to receive one of the blocks before surgery. Researchers will measure pa…

This study tests whether adding dexamethasone (a steroid) to a standard pain-blocking injection (liposomal bupivacaine) can keep the shoulder numb longer after arthroscopic surgery. 80 adults aged 18-80 will be randomly assigned to get the block with or without the steroid. Resea…

This study compares two types of nerve blocks (thoracolumbar interfascial plane block and retrolaminar block) to see which one helps patients recover better after lumbar spine fusion surgery. 70 adults scheduled for surgery will receive one of the two blocks before the procedure.…

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study compares two types of nerve blocks to control pain after laparoscopic hysterectomy. Sixty women aged 18-65 will receive either an Intertransverse Process Block or an M-TAPA block. The main goal is to see which block provides better pain relief in the first 24 hours aft…

This study will compare two types of nerve blocks (ITP and ESP) to see which one provides better pain relief after robotic colorectal surgery. Fifty adults having this surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure pain levels and …

This study will test two different nerve blocks to see which one controls pain better after laparoscopic sleeve gastrectomy. Sixty adults having this weight-loss surgery will receive either an intertransverse process block or an external oblique intercostal plane block. Researche…

This study tests whether injecting tramadol, with or without dexamethasone, into the knee joint after arthroscopy can reduce pain and the need for extra painkillers. About 135 adults having minor knee surgery will be randomly assigned to receive one of two drug combinations or a …

This study tests two different nerve blocks to see which one controls pain better after laparoscopic sleeve gastrectomy. Sixty adults having this weight-loss surgery will receive either an intertransverse process block or a subcostal transversus abdominis plane block. The goal is…

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

This study tests whether natural medicines (propolis and green tea extract) placed inside the tooth can reduce pain and sudden flare-ups after a root canal retreatment. Forty adults with a failed root canal on a single-rooted tooth will be randomly assigned to get either the stan…

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective…

This study tests a new type of nerve block (r-PVB) to reduce pain and improve recovery after laparoscopic gallbladder removal. About 250 adults having this surgery will either get the new block or standard care. The goal is to see if the block lowers pain scores and helps patient…

This study compares two common pain relief techniques after laparoscopic gallbladder removal: local anesthetic injected into the surgical cuts versus an ultrasound-guided nerve block near the belly button. The goal is to see which method better reduces pain and the need for opioi…

This study tests a new type of nerve block (r-PVB) to reduce pain and improve recovery after stoma closure surgery. 250 adults will receive either the new block or standard care. The goal is to see if the new method lowers pain scores and helps patients feel better faster.

This study compares two types of nerve blocks given before lung surgery to see which one controls pain better. Sixty adults having video-assisted lung surgery will receive either a serratus posterior superior intercostal plane block or a deep serratus anterior plane block. The ma…

This study compares two types of nerve blocks to see which provides better pain relief after breast cancer surgery that also removes lymph nodes. Sixty women aged 18-65 will receive one of the two blocks before surgery. Researchers will measure pain levels, opioid use, and side e…

This study compares a new, simpler nerve block method to the traditional one for people having lung surgery with a camera (VATS). The goal is to see if the new method works just as well for pain control and helps patients recover faster. About 200 adults will be randomly assigned…

This study compares two types of nerve blocks (iPACK and BiFeS) to see which one controls pain better after total knee replacement. One hundred adults having knee surgery will receive one of the two blocks with a numbing medicine (bupivacaine). Researchers will measure pain score…

This Phase 3 trial will test whether a single dose of methadone given during surgery can improve pain control and recovery compared to standard short-acting opioids. About 400 adults having intermediate-risk noncardiac surgery will take part. The main goal is to see if patients f…

This study tests whether a single 4 mg dose of dexamethasone, given as a shot under the gum before surgery, can reduce pain and difficulty opening the mouth after impacted lower wisdom tooth removal. 268 adults aged 18 to 55 will be randomly assigned to receive the steroid or sta…

This study compares two types of pain blocks used during mastectomy (breast removal surgery) to see which one is easier for doctors to perform and provides better comfort for patients. About 64 adults aged 25-65 having mastectomy will take part. The goal is to improve pain contro…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study tests if a magnesium drip given after a C-section can lower pain and help new mothers recover faster. About 150 women having planned or non-urgent C-sections will be randomly assigned to receive either magnesium or a saltwater placebo. Neither the patient nor the care …

This study tests whether listening to music and using Emotional Freedom Techniques (EFT) — a type of tapping on acupressure points — can help people recover better after knee arthroscopy. The goal is to reduce pain, fear of movement, and the risk of falling. Researchers will enro…

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This study compares two types of nerve blocks to see which one controls pain better after open gallbladder removal. Sixty-six adults will receive either an erector spinae plane block or an external oblique intercostal plane block before surgery. Researchers will measure pain scor…

This study looks at whether adding a steroid called dexamethasone to standard pain medicine helps people feel less pain after shoulder surgery. About 70 adults having shoulder arthroscopy will get either the steroid or a placebo, and researchers will measure how long it takes bef…

This early-stage study tests a new medicine called SYH9089 for pain after abdominal surgery. About 60 adults will receive either the new drug, an active painkiller, or a placebo. Researchers will check safety and how well it controls pain in the first days after surgery.

This study tests two different drugs—dexmedetomidine and low-dose ketamine—given during weight-loss surgery to see which one reduces pain and the need for morphine afterward. Ninety adults having bariatric surgery will be randomly assigned to one of the two drugs or a placebo. Th…

This study looks at whether adding electroacupuncture to standard numbing medicine can lower pain and stress during impacted wisdom tooth extraction. Sixty adults aged 25-35 will be split into three groups: real electroacupuncture, fake acupuncture, or no extra treatment. Researc…

This study tests if a surgeon can numb the knee during replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see if the surgeon's technique provides equal pain relief and r…

This study looks at two ways to manage pain after hip replacement surgery. One method numbs the front of the hip joint, and the other adds numbing to the back. The goal is to see if using both together provides better pain relief. About 40 adults having hip replacement will take …

This study tests an experimental pain medicine called CPL-01 in 112 adults who are having bunion surgery. Half will get the drug, half a placebo. Researchers will measure how much pain people feel and how much extra pain medicine they need. The goal is to see if CPL-01 provides b…

This study compares two ultrasound-guided nerve blocks to manage pain after heart surgery through the breastbone. 80 adults will receive one of the two blocks plus standard care. The goal is to see which block reduces opioid use and pain better in the first 24 hours after surgery…

This study compares two nerve-numbing techniques—Rhomboid-Intercostal Block (RIB) and Thoracic Paravertebral Block (PVB)—for pain relief after video-assisted chest surgery. Sixty adults will be randomly assigned to receive one of the two blocks after surgery. Pain levels and side…

This study tests whether a 5-minute guided breathing technique called box breathing can help older adults (65+) manage stress and recover better after total knee replacement. Thirty-two participants will be randomly assigned to either the breathing exercise or a control activity.…

This study compares two common root canal cleaning solutions—chlorhexidine and sodium hypochlorite (bleach)—to see which one leads to less pain the day after the procedure. About 90 adults needing a root canal will be randomly assigned to one of the two solutions. Participants wi…

This study compares a nerve block (PENG) to spinal morphine for pain after total hip replacement. About 180 adults will be randomly assigned to one of three groups: PENG block, spinal morphine, or spinal anesthesia alone. The goal is to see which method provides better pain contr…

This study tests two methods to reduce pain after keyhole stomach surgery for cancer. One method uses a standard ultrasound-guided nerve block, while the other applies a special temperature-sensitive gel mixed with numbing medicine directly to the surgical site. The goal is to se…

This study compares two common nerve block techniques for shoulder surgery pain. Sixty adults having arthroscopic shoulder surgery will receive either an interscalene block alone or a combined interscalene and suprascapular block. Researchers will measure pain scores, painkiller …

This study tests if using scalp nerve blocks and a drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having brain surgery will be randomly assigned to receive one or both treatments, or…

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This study compares two types of nerve blocks (M-TAPA and ESPB) to see which provides better pain relief after laparoscopic gallbladder removal. About 124 adults having elective surgery will receive one of the two blocks, and researchers will measure pain scores, opioid use, and …

This study tests a combination of two pain-relief methods—a sedative drug called dexmedetomidine and a local anesthetic injected into the scalp—for people undergoing brain tumor surgery. The goal is to see if this approach reduces the need for strong opioid painkillers after surg…

This study tests whether spraying a numbing medicine (bupivacaine with epinephrine) over the diaphragm during laparoscopic gynecologic surgery can reduce shoulder pain afterward. About 100 women will be randomly assigned to receive the spray or a placebo. The main goal is to see …

This study looks at three ways to manage pain after mastectomy: standard pain medication, a nerve block called rhomboid intercostal block (RIB), or a combination of RIB with another nerve block. Researchers will review medical records of 66 women to see which method provides the …

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40 to 70 will choose whether to use the pillow or not. Their pain, sleep quality, and shoulder function will be checked …

This study tests a nerve block given during minimally invasive colorectal surgery to see if it reduces pain and the need for opioids. Researchers will track 400 adults having left-sided colon or rectal surgery. The goal is to improve recovery and reduce side effects like nausea.

This study compares two types of nerve blocks (SAP and SPSIP) to see which one provides better pain relief after mammoplasty (breast surgery). Sixty women aged 18-85 will receive one of the blocks along with a numbing medicine (bupivacaine). Researchers will measure pain scores, …

This study tests two simple, drug-free methods—vibration and breathing exercises—to see if they can reduce pain and anxiety when a chest tube is removed after surgery. About 70 adults will be randomly assigned to vibration, breathing exercises, or standard care. If effective, the…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults having major back surgery will be randomly assigned to receive either the real stimulati…

This study looks at whether a device called TENS, which sends mild electrical pulses through the skin, can help reduce pain and improve sleep after inguinal hernia surgery. About 80 adults having this surgery will either receive TENS or standard care. Researchers will measure pai…

This study tests whether rinsing with hydrogen water can reduce mouth inflammation and pain in people recovering from oral cancer surgery that used a free flap reconstruction. Thirty-six participants will use hydrogen water or plain water for oral care over 7 days. Researchers wi…

This study compares two ultrasound-guided nerve blocks (TFP and ESP) to control pain after cesarean section. The goal is to see which block provides better pain relief and reduces the need for opioid painkillers. Sixty women having a planned C-section will participate, and their …

This study compares a nerve block (injecting numbing medicine near the ear) to standard painkillers (fentanyl and ketorolac) for children aged 6 months to 6 years having ear tube surgery. The goal is to see if the nerve block works just as well for pain control, with fewer side e…

This study compares two common ultrasound-guided nerve block techniques used to reduce pain and improve recovery after laparoscopic gallbladder removal. 76 adults will receive one of two blocks while under anesthesia. The main goal is to see which method leads to a better recover…

This early-stage trial tests a new oral drug called KHN702 for moderate to severe pain after surgery. About 24 adults will receive either the drug or a placebo to see if it is safe and helps reduce pain. The study is double-blind, meaning neither patients nor doctors know who get…

This study tests whether a 20-minute hot water foot bath can reduce pain and help patients pass gas sooner after laparoscopic gallbladder removal. 62 adults will be randomly assigned to receive the foot bath or standard care. The goal is to see if this simple, drug-free method im…

This study compares two types of nerve blocks (QIPB and SIFICB) to see which one works better for pain after hip surgery. About 60 adults having hip surgery will take part. The goal is to find which block lowers pain scores and reduces the need for extra pain medicine.

This study tests whether a modified nerve block called M-TAPA, given before open-heart surgery, can reduce pain and the need for strong painkillers (opioids) afterward. The block is injected under ultrasound guidance near the ribs. Eighty adults having elective open-heart surgery…

This study will test whether taking acetaminophen (Tylenol) by mouth works as well as getting it through an IV for pain after lumbar spine fusion surgery. About 180 adults will be randomly assigned to receive either oral or IV acetaminophen for 48 hours after their operation. The…

This study tests whether using a small vibration tool after wrist fracture surgery can reduce pain and the need for opioid painkillers. One hundred adults who have had surgery for a broken wrist will be randomly assigned to use the vibration tool or not. Researchers will measure …

This study tests whether a special nerve block, called SPSIPB, can reduce pain and the need for strong painkillers after heart surgery. 120 adults having planned heart surgery will either get the block plus standard care, or standard care alone. The goal is to see if the block le…

This trial compares two types of nerve blocks—erector spinae plane block and external oblique-intercostal plane block—for pain relief after open ventral hernia repair. Fifty adults scheduled for surgery will receive one of the two blocks, and researchers will measure how much ext…

This study compares three types of nerve blocks used for pain relief during shoulder surgery. The goal is to see which block is least likely to temporarily paralyze the diaphragm, the main muscle used for breathing. Seventy-five adults having shoulder surgery will be randomly ass…

This study explores whether detailed pain mapping and sensory tests can better capture pain patterns after lung surgery. Researchers will assess pain sensitivity around the incision and track recovery for three months. The goal is to see if these methods are practical and could h…

This study watches anesthesia residents as they place epidural catheters in 440 patients having elective surgery. It compares two common techniques—loss of resistance and hanging drop—to see which leads to more first-attempt successes and fewer complications like accidental dural…

This study tests three different ways to numb the abdomen in healthy volunteers to see which works best. Each volunteer gets all three blocks on separate days, and researchers map the numb areas and check leg strength. The goal is to improve pain relief after surgery without usin…

This study watches 250 children aged 2 to 8 who are having urogenital surgery. Researchers want to see if the time they fast (no food or drink) before the operation changes how much pain or confusion they feel afterward. The goal is to learn if shorter fasting times could help ki…

This study looks at whether a skin monitor can reliably measure pain in newborns after surgery. Since babies can't tell us they're in pain, doctors currently use checklists and vital signs. The monitor tracks skin conductance, a sign of stress. Researchers will compare it to stan…

This study will check if measuring belly muscle thickness with ultrasound before surgery can help predict how much opioid pain medicine older patients need after abdominal surgery. Researchers will follow 62 patients aged 65 and older for 24 hours after surgery, recording pain sc…

This study follows 100 adults having their thyroid removed to see how different pain relief methods (like a nerve block) affect recovery and swallowing pain. It is purely observational, meaning no new treatment is given. The goal is to gather information to improve future care.

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study will observe 50 adults undergoing total knee replacement to see how different anesthesia methods affect pain and painkiller use in the first 48 hours after surgery. Participants receive either general anesthesia with a nerve block, spinal anesthesia with a nerve block,…

This study will observe 100 adults having gallbladder surgery to see if their pre-surgery anxiety and pain from getting an IV can predict how much pain they feel after the operation. Researchers will measure anxiety with a questionnaire and IV pain with a 0-10 scale, then track p…

This study looks at whether the position you are in when you get a nerve block for chest surgery changes how well it works. Researchers will compare sitting up versus lying on your side in 90 adults having video-assisted chest surgery. The goal is to see which position gives bett…

This study looks at how a new pain medicine called Anrikefon works in older adults after laparoscopic belly surgery. Thirty people aged 65 and older will receive the drug and have their blood tested to measure drug levels. The goal is to understand how the drug behaves in older b…