POSTOPERATIVE PAIN

This study aims to understand how a new pain medication called Anrikefon is processed in the bodies of older adults after abdominal surgery. It will enroll 30 participants aged 65 and older to measure the drug's levels in their blood. The goal is to gather information to help det…

This study is testing whether two types of breathing exercises can help patients feel better after breast cancer surgery. Researchers will compare pranayama (alternate nostril breathing) and pursed-lip breathing against standard care to see if they reduce pain and anxiety. The go…

This study is testing if simple, drug-free methods can make it easier for patients when a chest tube is removed after surgery. Researchers will compare whether using a gentle vibrating device or doing guided breathing exercises right before the procedure helps reduce pain and anx…

This early-stage study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and practical to give to adults recovering from major trauma surgery who also have opioid use disorder. Researchers want to see if this one-time dose can help …

This study aims to find the best way to manage pain after hip replacement surgery. It will compare two different types of nerve-block injections given at the end of the operation. Researchers will measure which method provides better pain relief with less leg weakness in 70 patie…

This study is testing whether a specific nerve block given before surgery can reduce pain and the need for strong painkillers after a laparoscopic hysterectomy. Sixty women having this common surgery will be randomly assigned to receive either the nerve block or standard pain car…

This study is testing whether a simple breathing exercise called 'Box Breathing' can help older adults recover better from knee replacement surgery. Researchers will see if this easy, at-home technique can reduce the body's stress response after surgery, which may lead to less pa…

This study is testing two different non-opioid methods to help manage pain after brain tumor surgery. It will involve 2,000 patients to see if using a local nerve block before surgery or a specific sedative during surgery can reduce the need for strong opioid painkillers afterwar…

This study aims to find the best method for managing pain after open-heart surgery. It will compare two different ultrasound-guided nerve-block techniques in 80 adult patients. The main goal is to see which method reduces the need for strong opioid painkillers in the first day af…

This study aims to find which of two common pain-numbing injections works better for recovery after keyhole gallbladder surgery. Researchers will randomly assign patients to receive one of the two nerve-block techniques while they are asleep at the end of the operation. The main …

This study is testing a new type of nerve-block injection, given before surgery, to see if it can better control pain after heart surgery. Researchers will compare pain levels and opioid painkiller use in 120 adults who receive the new block versus standard care. The goal is to f…

This study is testing a new combination of nerve blocks to better manage pain after open-heart surgery. Researchers want to see if this approach reduces the need for strong opioid painkillers, which can cause side effects like nausea and breathing problems. The goal is to help pa…

This study is testing if applying a gel called RADA16 during tonsil removal surgery helps children recover better. Researchers want to see if the gel reduces pain, bleeding, and the need for strong painkillers after the operation. About 134 children aged 3-17 will be randomly ass…

This study tests whether gentle electrical stimulation on the ear can help reduce pain and the need for strong painkillers after complex spine surgery. Researchers will enroll 98 patients having major spinal operations. Participants will be randomly assigned to receive either rea…

This study is testing a new technique to better control pain after minimally invasive colon surgery. During the operation, surgeons will inject a numbing medicine around specific nerves that carry pain signals from the bowels. The goal is to see if this targeted 'nerve block' hel…

This study is testing if a non-drug treatment called TENS (transcutaneous electrical nerve stimulation) can help reduce pain and improve sleep for people recovering from hernia surgery. 80 adults having the surgery will be randomly assigned to receive either standard care or stan…

This study aims to find which of two nerve-numbing techniques provides better pain relief after minimally invasive chest surgery. Researchers will randomly assign 60 adults having chest surgery to receive either the Rhomboid-Intercostal Block or the Thoracic Paravertebral Block. …

This study aims to find the best way to manage pain after minimally invasive stomach cancer surgery. It will compare two established methods: a numbing injection guided by ultrasound versus a special gel applied directly to the surgical site. The goal is to see which method provi…

This study compares two methods of numbing nerves to control pain after shoulder surgery. Researchers want to see which method provides better pain relief with fewer side effects, particularly breathing problems. Sixty patients having shoulder surgery will receive one of the two …

This study is testing whether a specific type of nerve block (an Erector Spinae Plane block) can better control pain after spinal fusion surgery. Researchers will compare two different numbing medications to see which one helps patients use fewer opioid painkillers, feel less pai…

This study is testing if a new type of ultrasound-guided nerve block, given on both sides of the abdomen, can help control pain and reduce the need for opioid painkillers after laparoscopic gallbladder removal. Researchers will compare 56 patients who receive the nerve block to t…

This study is testing whether using hydrogen-rich water for mouth care helps patients recover better after oral cancer surgery. It will compare hydrogen water against plain water in 36 patients who had reconstructive surgery. Researchers will measure pain, mouth inflammation, and…

This study aims to find out if the type of cleaning solution used during a root canal affects how much pain a patient feels the next day. Researchers will compare two common solutions—chlorhexidine and a bleach-based solution—in 90 adults getting root canals. Participants will ra…

This study is testing a combination approach to manage pain after brain tumor surgery. It will compare different methods of delivering pain medication to see which best reduces the need for strong opioid drugs. The goal is to find a safer, more effective way to control pain and s…

This study is testing if a local anesthetic spray applied during surgery can reduce shoulder pain that often occurs after laparoscopic gynecologic procedures. It will involve 100 patients at Cedars-Sinai Medical Center, comparing the spray to a placebo. The main goal is to see if…

This study aims to find out if a patient's position during a pain-blocking injection affects how well it works after chest surgery. Researchers will compare the injection given while patients are sitting up versus lying on their side. The goal is to see which position provides be…

This study is testing whether a combination of two drugs given as a nasal spray can better control pain in children after they have their tonsils and/or adenoids removed. The trial will involve 160 children aged 3 to 7. Researchers want to see if this spray reduces pain and impro…

This study is testing whether a special pillow placed behind the shoulder can help reduce pain and improve sleep for people recovering from surgery to repair a torn rotator cuff. Researchers will compare patients who choose to use the pillow with those who do not, tracking their …

This study aims to find which anesthesia method provides better pain relief after knee replacement surgery. Researchers will observe 50 patients receiving different anesthesia combinations to see which one results in less pain and requires fewer pain medications during the first …

This is an early safety study for a new pain medication called KHN702 tablets. It will test if the drug is safe and can help reduce moderate to severe pain in the first 48 hours after surgery. The study will involve 24 patients who will receive either the new drug or a placebo (a…

This study compares two different nerve-block injection techniques for managing pain after breast enhancement surgery. Researchers will enroll 60 women to see which method—the standard SAP block or a newer SPSIP block—provides better pain relief with less need for opioid painkill…

This study compares two different nerve block techniques to see which one better controls pain and reduces opioid painkiller use after laparoscopic gallbladder removal surgery. Researchers will test these blocks against standard pain medication in 147 patients. The goal is to fin…

This study aims to find which of two established nerve block techniques provides better pain relief after open hernia repair surgery. Researchers will compare two methods—one injected near the spine and one near the ribs—in 50 patients. The goal is to reduce post-surgery pain, na…

This study aims to find out if taking Tylenol (acetaminophen) as a pill works just as well as getting it through an IV for pain after spinal fusion surgery. Researchers will enroll 180 patients to see which method provides better pain control, reduces the need for stronger opioid…

This study compares two different nerve block techniques for managing pain after laparoscopic gallbladder removal surgery. Researchers will randomly assign 124 adult patients to receive either the M-TAPA or ESPB nerve block before surgery. They'll measure which method provides be…

This study is testing if rinsing the abdomen with salt water during a specific type of scarless hysterectomy (vNOTES) can further reduce pain after surgery. Researchers want to see if this simple step helps more than just using low gas pressure during the procedure alone. They wi…

This study aims to find which of two ultrasound-guided nerve block techniques works better to control pain after a cesarean section. Researchers will compare the Transversalis Fascia Plane block and the Erector Spinae Plane block in 60 women having planned C-sections. The main go…

This study is testing whether a simple vibration tool can help control pain after surgery for a broken wrist. Researchers want to see if this non-drug approach can reduce patients' pain and their need for opioid pain medication. The study will involve 100 patients who are receivi…

This study aims to see which of two targeted numbing injections works better for pain relief after knee replacement surgery. Researchers will compare the iPACK block and the BiFeS block in 100 patients to see which one controls pain more effectively, reduces the need for strong p…

This study compares two ways to manage pain in young children after a common ear tube procedure. It tests if a targeted numbing injection near the ear (Nerve of Arnold block) works as well as the standard combination of pain shots (fentanyl and ketorolac). The goal is to see if t…

This study looks back at medical records to compare three different approaches to managing pain after breast removal surgery. Researchers will examine pain levels, opioid medication use, and patient satisfaction in 66 women who had surgery between October 2024 and 2025. The goal …

This study is testing if adding a specific nerve block to standard pain medicine helps people feel better after back surgery. Fifty patients having planned spine surgery will be randomly chosen to get either the new nerve block plus standard care or just standard care alone. The …

This study is testing if a simple, warm foot bath can help people feel better after having their gallbladder removed through keyhole surgery. Researchers want to see if soaking the feet for 20 minutes can reduce pain and help the digestive system 'wake up' faster after the operat…

This study is testing a new type of nerve block injection to see if it can better control pain after major abdominal surgeries like gallbladder or liver operations. Researchers will compare patients who get the new block plus standard pain care against those who get standard care…

This study is testing whether a specific nerve-blocking injection can help people recover better after hip replacement surgery. Researchers will compare recovery quality, pain levels, and medication use between patients who receive the nerve block and those who get standard pain …

This study is testing if a Botox injection given a week before hemorrhoid surgery can reduce pain after the operation. Researchers will compare Botox to a placebo injection in 292 adults with severe hemorrhoids. The main goal is to see if relaxing the anal muscle with Botox leads…

This study compares two different nerve block techniques to see which provides better pain relief after hip surgery. Sixty patients will be randomly assigned to receive either the Quadroiliac Plane Block or the Suprainguinal Fascia Iliaca Compartment Block during their procedure.…

This study aims to see if a patient's pain from getting an IV needle and their anxiety before surgery can help predict how much pain they will feel after a common gallbladder removal operation. Researchers will observe 100 adults having this elective surgery, measuring their need…

This study aims to understand how patients feel about routine pain monitoring after elective surgery. Researchers will survey and interview 300 patients to learn whether they view these checks as supportive or stressful, and how these perceptions affect their trust in nurses, anx…