Knee surgery pain relief: could a simple injection reduce opioid use?

NCT ID NCT07064993

Not yet recruiting Symptom relief Sponsor: Arzu Esen Tekeli Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether injecting tramadol, with or without dexamethasone, into the knee joint after arthroscopy can reduce pain and the need for extra painkillers. About 135 adults having minor knee surgery will be randomly assigned to receive one of two drug combinations or a placebo. The main goal is to measure pain levels over the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tramadol and dexamethasone
What this could lead to: If it works, this could offer a simple, effective way to manage pain right after knee surgery, reducing the need for strong painkillers.
What could go wrong: This is a small, early-phase trial, so results may not apply to everyone. There is also a risk of side effects like nausea or itching from the medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHILLS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILLS ITCHING KNEE ARTHROSCOPY NAUSEA AND VOMITTING POSTOPERATIVE PAIN VAS WILL BE USED TO ASSESS PAIN POSTOPERATIVE

Contacts and locations

Locations

Van Yuzuncu Yil University School of Medicine Department of Anesthesiology and Reanimation

Van, 65100, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.