Opioid-Free anesthesia for kidney stone surgery shows promise in new trial

NCT ID NCT07636070

Not yet recruiting Symptom relief Sponsor: murat sahin Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a combination of two drugs, dexmedetomidine and ketamine, can replace opioids for pain control during kidney stone surgery. Sixty adults undergoing the procedure will receive either the opioid-free combo or standard fentanyl-based anesthesia. Researchers will measure pain levels and how much extra pain medication is needed after surgery, aiming to find a safer alternative to opioids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexmedetomidine and ketamine combination
What this could lead to: If successful, this could offer a safer, opioid-free pain management option for kidney stone surgery, reducing reliance on opioids and their side effects.
What could go wrong: This is a small, early-stage trial with only 60 participants, so results may not apply to everyone. The new approach might not control pain as well as standard opioids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY STONE POSTOPERATIVE PAIN RETROGRADE INTRARENAL SURGERY (RIRS)

Contacts and locations

Locations

Mus State Hospital

Muş, Muş, 49100, Turkey (Türkiye)

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