Nephrolithiasis

This study tests whether using a hemostatic agent (a substance that stops bleeding) during kidney stone surgery can reduce blood loss compared to standard care. About 92 adults with kidney stones will be randomly assigned to receive either a hemostatic agent or no agent during th…

This study tests whether using an antibiotic (gentamicin) in the irrigation fluid and a special suction tube during kidney stone surgery can lower the chance of fever, inflammation, or sepsis afterward. About 180 adults having this surgery will be randomly assigned to receive one…

This study is tracking 238 adults who are already scheduled to have a procedure for kidney stones or an enlarged prostate (BPH) using Boston Scientific devices. The main goal is to see how often serious side effects happen with these tools in real-world use. Researchers will also…

This study tests whether hydroxycitrate, a molecule similar to citrate, can reduce the recurrence of calcium phosphate kidney stones. Researchers will give 25 stone formers either hydroxycitrate, potassium citrate, or a placebo, and measure how well their urine prevents stone for…

This study tests whether giving people a live gut bacterium called Oxalobacter formigenes can lower the amount of oxalate in their urine. High urinary oxalate is a major risk factor for calcium oxalate kidney stones. Forty adults with a history of such stones who lack this bacter…

This study tests a new device called the CVAC system that uses suction during a scope procedure to remove kidney stones. It compares how well this works versus the usual method (laser and no suction) in 150 adults. The main goal is to see if the new tool leaves fewer stone fragme…

This study tests a new technique called Burst Wave Lithotripsy (BWL) that uses bursts of low-amplitude ultrasound to break kidney stones into tiny pieces during a standard surgical procedure. About 40 adults scheduled for stone removal will receive BWL to see if it is safe and ef…

This study looks at the best time to use shock waves to break up small leftover kidney stones after surgery. About 476 adults with stones 15 mm or smaller will be randomly assigned to get treatment either early (1-2 weeks after surgery) or later (3-4 weeks after). The goal is to …

This study compares three different single-use flexible ureteroscopes used to remove kidney stones. Researchers will look at cost, how long the surgery takes, complications, and how well the stones are cleared. About 180 adults with small-to-medium kidney stones will take part.

This study compares two types of lasers used to break up kidney stones during a minimally invasive procedure called ureteroscopy. One laser uses a superpulse thulium fiber (sTFL), the other is a standard holmium laser. Researchers will enroll 136 adults aged 18–70 with kidney sto…

This study tests whether a DASH-style diet (rich in fruits, vegetables, and low-fat dairy) can reduce the risk of kidney stones compared to a typical Western diet. Forty-eight adults with a history of kidney stones will eat specially prepared meals for one week. Researchers will …

This study compares two modern, minimally invasive surgeries for removing kidney stones that are 2-3 cm in size. About 120 adults will be randomly assigned to either mini-percutaneous nephrolithotomy (Mini-PCNL) or flexible ureteroscopy with a suction sheath. The goal is to see w…

This study tests a new ultrasound device that can break kidney stones into tiny pieces and reposition them, all without anesthesia. Researchers will enroll 140 people with small kidney stones to see if the procedure is safe and helps stones pass naturally. The goal is to offer a …

This study is testing whether a simple, standard prevention plan works as well as a personalized one for people who get calcium oxalate kidney stones. 80 participants will either receive a diuretic and diet advice based on their stone type alone, or have their treatment guided by…

This study is testing a new type of ureteral stent that is designed to slowly dissolve and pass out of the body on its own after being placed during kidney stone surgery. The goal is to see if it safely drains urine and breaks down within 90 days, so patients don't need a second …

This trial tests a new device called VISOR for removing kidney stones. It combines stone breaking, suction, and pressure control in one tool. About 20 adults with 1-3 cm stones will undergo surgery with VISOR. The goal is to see if it clears stones safely and effectively, with a …

This study tests whether a special hydrogel, squirted into the kidney after laser stone removal, can trap tiny leftover fragments and be pulled out whole. About 120 adults with kidney stones larger than 10 mm will be randomly assigned to standard surgery alone or surgery plus the…

This pilot study is testing whether it's practical to add an abdominal CT scan to the standard lung cancer screening for people aged 55-70 who have smoked. The goal is to see if this extra scan can detect kidney cancer, abdominal aortic aneurysms, and kidney stones without slowin…

This study compares two long-acting drugs, indapamide and chlorthalidone, to the standard short-acting drug hydrochlorothiazide for preventing calcium kidney stones. About 99 adults who have had at least two kidney stones in the past 10 years will participate. The goal is to see …

This study tests whether empagliflozin, a drug used for diabetes and heart conditions, can help prevent calcium-based kidney stones. Researchers will give the drug daily for 4 weeks to 32 adults who have had calcium oxalate or calcium phosphate stones. They will measure changes i…

This study compares two surgical methods for removing kidney stones: one using a vacuum-assisted sheath and the other using a standard sheath. About 90 adults with stones between 10-25 mm will be randomly assigned to one of the two procedures. The goal is to see which method clea…

This study compares two versions of a shockwave machine for breaking kidney stones: one with stone tracking and one without. About 126 adults with a single kidney stone (6-15 mm) will be randomly assigned to either group. The goal is to see if the tracking feature helps more peop…

This study compares two breathing machine settings during kidney stone surgery to see which one gives surgeons a clearer, steadier view inside the kidney. Sixty adults having elective surgery will be randomly assigned to either normal or low tidal volume ventilation. The goal is …

This study tests two different tubes used during kidney stone surgery to see which one works better. One tube has suction to remove stone pieces and fluid, while the other does not. Researchers will track how many patients are stone-free after surgery and compare complication rat…

This study compares two types of ultrasound-guided nerve blocks for pain control after open kidney removal surgery. Ninety adults will receive either a rhomboid intercostal sub-serratus plane block or an external oblique intercostal block. Researchers will measure how long it tak…

This study tests if taking tamsulosin before surgery or using aminophylline during surgery helps doctors place a tube needed for kidney stone removal. About 322 adults with small kidney stones will be randomly assigned to receive one or both medications or placebos. The goal is t…

This study tests whether a high dose of the steroid dexamethasone (20 mg) can reduce urinary symptoms and pain after kidney stone surgery when a temporary stent is placed. About 70 adults will receive either the high dose or a standard dose (4 mg) during surgery and report their …

This study tests a new type of ureteric stent designed to cause fewer blockages, infections, and less pain than standard stents. About 50 adults who have had stents before for kidney stones or cancer will try the new stent. The goal is to see if it reduces complications and the n…

This study compares two types of lasers (holmium:YAG and thulium fiber) used during a minimally invasive surgery to break up large kidney stones. About 150 adults with stones larger than 15 mm will be randomly assigned to one laser or the other. The goal is to see which laser wor…

This study compares a new, thinner flexible scope (HugeMed 6.3 French) to standard scopes for removing kidney stones up to 2.5 cm. Researchers want to see if the new scope saves money while still clearing stones just as well. About 75 adults with kidney or ureter stones will take…

This study tests whether combining tamsulosin with either a standard or half dose of tadalafil can better relieve symptoms caused by ureteric stents, such as pain, urgency, and discomfort. Researchers will enroll 140 adults who have a stent placed after kidney stone removal. The …

This study compares two common surgeries for removing kidney stones: mini-PCNL (a small incision in the back) and flexible ureteroscopy with a special suction tube. About 80 adults with kidney stones between 1 and 3 cm will be randomly assigned to one procedure. The main goal is …

This study tests a new biodegradable stent (Hydrustent) that dissolves on its own after being placed in the ureter following kidney stone removal. The goal is to see if it keeps urine flowing safely and reduces the need for a second procedure to remove the stent. About 134 adults…

This study tests whether a nerve block called an erector spinae plane (ESP) block can reduce pain and the need for opioid painkillers after percutaneous nephrolithotomy, a surgery to remove large kidney stones. About 128 adults having this surgery will be randomly assigned to rec…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study tests a new robotic system designed to help surgeons remove kidney stones. The robot controls the surgical tools and can even perform some steps on its own with AI guidance. The trial will include 15 adults with small kidney stones to see if the robot can complete the …

This study tests a simple change during kidney stone surgery: actively suctioning the kidney to collapse it at the end of the procedure, instead of letting it drain naturally. Researchers want to see if this reduces pain and infection right after surgery. About 90 adults with kid…

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study tests a new flexible suction sheath (FANS) against the traditional sheath for kidney stone removal surgery. About 80 adults with small-to-medium kidney stones will be randomly assigned to one of the two tools. The main goal is to see which tool leaves fewer stone fragm…

This Phase 3 trial tests whether a single spinal injection of morphine and bupivacaine before robotic kidney or ureter surgery leads to better recovery than an intravenous lidocaine drip during surgery. About 220 adults scheduled for robotic upper urinary tract surgery will be ra…

This study compares a new bendable tip-suction ureteral access sheath to a standard one during surgery for large kidney stones (staghorn stones). About 100 adults will be randomly assigned to one of the two sheaths. The goal is to see if the new sheath reduces complications and c…

This study tests whether taking the steroid prednisone after ureteroscopy (a surgery for kidney stones) can help reduce pain and the need for other pain medications. Researchers will enroll 90 adults who are having this surgery with a stent placed. The goal is to see if adding a …

This pilot study is testing whether a single injection of ketorolac (Toradol), given just before ureteral stent placement, can reduce pain and inflammation afterward. About 36 adults undergoing kidney stone surgery will be randomly assigned to receive either ketorolac or a placeb…

This study looks at whether leaving a stent out after kidney stone surgery can reduce pain and the need for extra medical visits. About 184 adults with kidney or ureteral stones will be randomly assigned to either get a stent or not after their procedure. Researchers will track p…

This study looks at whether it is safe and less painful to skip placing a temporary tube (stent) after routine kidney stone removal. About 792 adults with small stones will either get a stent or not, and researchers will track pain and any unplanned doctor visits. The goal is to …

This study compares two common treatments for kidney stones that are 1 to 2 centimeters in size. One treatment uses shock waves from outside the body to break up the stone, while the other uses a thin scope and laser through the urinary tract. Researchers will measure how complet…

This study compares two minimally invasive procedures—semi-rigid and flexible ureteroscopy—for removing upper ureter stones smaller than 2 cm. Researchers will measure which method clears stones more effectively, how long the surgery takes, and overall costs. The trial enrolls 10…

This study tests whether giving a water pill (furosemide) and extra fluids during laser kidney stone surgery helps clear out tiny leftover fragments. About 374 adults who need this surgery will be randomly assigned to receive either the water pill plus fluids or standard care. Th…

This study tests a flexible suction sheath (FANS) used with a ureteroscope to remove kidney stones from the lower part of the kidney. About 33 adults with lower calyceal stones will be enrolled. The goal is to see if the device helps clear all stones completely.

This study tests whether placing the numbing drug bupivacaine into the bladder after kidney stone surgery can reduce pain and bladder spasms. About 116 adults will be randomly assigned to receive either the drug or a saltwater placebo. The goal is to see if this simple step impro…

This study tests whether two common blood pressure drugs, terazosin and tamsulosin, can reduce urinary symptoms like pain and urgency after a ureteral stent is placed. 150 adults in Malaysia will be randomly assigned to take one of the drugs or receive standard care for 14 days. …

This large observational study will follow 4,000 adults undergoing percutaneous nephrolithotomy (PCNL) for kidney stones across many international centers. Researchers will track which surgical techniques are used, how well they clear stones, and what complications occur. The goa…

This study aims to find out if people who get calcium oxalate kidney stones produce more oxalate in their bodies than healthy people. Researchers will compare 80 adults—some with a history of stones and some without—after they eat a special low-oxalate diet and take small amounts…

This study aims to find out if people who get calcium oxalate kidney stones absorb more oxalate from food than healthy people. Researchers will compare stone formers and healthy volunteers by having them eat special diets and measuring oxalate in urine, blood, and stool. The goal…

This study tests a new training tool for kidney stone surgery. Trainee surgeons wear augmented reality goggles that show them where an expert surgeon is looking during the operation. The goal is to help trainees learn to explore the kidney more completely, which could reduce the …

This study aims to understand how oxalate, a substance found in many foods, contributes to kidney stone formation and affects the body's immune system. Researchers will enroll 88 healthy volunteers and people with calcium oxalate kidney stones. Participants will follow a controll…

This study is testing a device called RetroPerc, which helps doctors reach kidney stones during surgery. About 150 adults with kidney stones will take part. The goal is to see how often the device successfully gets to the stone and how long it takes.

This study is testing a new ureteroscope that shows surgeons the pressure inside the kidney in real time during stone removal. Researchers want to see if having this information changes how surgeons operate and leads to better outcomes. The study will enroll 80 adults with large …

This study is for older adults, including those in the hospital or with low priority care needs. Researchers want to see if newer methods, like body scans and blood tests, can better detect malnutrition and kidney problems than current standard tests. The goal is to make diagnosi…

This study looks at whether using a special suction device during kidney stone surgery can reduce how much irrigation fluid gets absorbed into the body and lower the risk of infections. Researchers will compare 400 adults who have surgery with or without the suction sheath. The g…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…

This study looks at how two natural compounds in food—oxalate and citrate—affect the chance of forming kidney stones. Researchers will measure changes in urine after participants consume sodium oxalate. The goal is to better understand why some people develop stones while others …

This study looks at how two natural compounds in food, oxalate and citrate, interact in the body and affect kidney stone formation. Researchers will measure changes in urine levels of these compounds after participants consume potassium citrate. The study includes 24 adults, some…

This observational study at the University of Chicago looks at how kidney stones are linked to insulin resistance and inflammation. Researchers will measure belly fat, blood markers, and urine in 40 people—half with calcium kidney stones and half without. The goal is to understan…

This study is testing whether a blood test that measures endotoxin levels can predict the risk of infection after a type of kidney stone surgery called percutaneous nephrolithotomy (PCNL). Researchers will enroll 150 adults scheduled for this surgery and measure their endotoxin l…