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Can a One-Size-Fits-All pill beat kidney stones?

NCT ID NCT07225764

Recruiting now Disease control Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a simple, standard prevention plan works as well as a personalized one for people who get calcium oxalate kidney stones. 80 participants will either receive a diuretic and diet advice based on their stone type alone, or have their treatment guided by detailed urine tests. The goal is to see if the simpler approach can lower the risk of future stones without the need for complex testing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Chlorthalidone (a diuretic) and a low oxalate diet
What this could lead to
If successful, this could show that a simpler, cheaper prevention plan works just as well as a more complex, personalized one, making stone prevention more accessible.
What could go wrong
This is a small, early-phase trial (80 people) looking at a lab marker, not actual stone recurrence. The simpler approach may not be as effective for everyone, and the drug has potential side effects like low potassium or dizziness.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis nephrolithiasis, calcium oxalate

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY STONES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mount Sinai West

    RECRUITING

    New York, New York, 10019, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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