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Could a daily vitamin e pill help dissolve kidney stones?

NCT ID NCT07715643

Disease control Sponsor: University of Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study investigates whether taking vitamin E supplements, at 200 mg or 400 mg per day, can reduce calcium oxalate crystals in people with kidney stones. Participants continue their usual medications while adding vitamin E. The goal is to see if this antioxidant can help manage stone formation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vitamin E dietary supplement at 200 mg or 400 mg per day
What this could lead to
If effective, vitamin E could become a simple, low-cost addition to standard care for managing calcium oxalate kidney stones.
What could go wrong
This is a small, early-stage trial with only 48 participants, so results may not apply broadly. Vitamin E supplements can also cause side effects at high doses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

48 people

The number who actually took part.

Started

Dec 2022

Finished

Apr 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Both male and female. * Participants between the age of 20-50 years old. * Presence of calcium oxalate crystals in urine and kidneys * The size of the stones will range from 2 to 5 mm. Exclusion Criteria: * People having stones of Uric acid, struvite, Cystine. * People having any other medical condition (End stage renal disease, Chronic Kidney disease, Kidney failure, and dialysis) . * Subjects were excluded if they were taking any medications, which might affect vitamin E metabolism (such as Wrafrin, dalteparin sodium, enoxaparin sodium). * Pregnant and lactating females. * People having known allergies to Vitamin E supplementation (rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing). * Participants enrolled in other studies or taking other nutraceutical preparations.

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Conditions

The condition(s) this trial relates to.

nephrolithiasis nephrolithiasis, calcium oxalate

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Calcium oxalate kidney stones Nephrolithiasis

Contacts and locations

Locations

  • The University of Lahore

    Lahore, Pakistan

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