NEPHROLITHIASIS

This study tests whether using a hemostatic agent (a substance that stops bleeding) during kidney stone surgery can reduce blood loss compared to standard care. About 92 adults with kidney stones will be randomly assigned to receive either a hemostatic agent or no agent during th…

This study tests whether giving people a live gut bacterium called Oxalobacter formigenes can lower the amount of oxalate in their urine. High urinary oxalate is a major risk factor for calcium oxalate kidney stones. Forty adults with a history of such stones who lack this bacter…

This study looks at the best time to use shock waves to break up small leftover kidney stones after surgery. About 476 adults with stones 15 mm or smaller will be randomly assigned to get treatment either early (1-2 weeks after surgery) or later (3-4 weeks after). The goal is to …

This study compares three different single-use flexible ureteroscopes used to remove kidney stones. Researchers will look at cost, how long the surgery takes, complications, and how well the stones are cleared. About 180 adults with small-to-medium kidney stones will take part.

This study tests whether a special hydrogel, squirted into the kidney after laser stone removal, can trap tiny leftover fragments and be pulled out whole. About 120 adults with kidney stones larger than 10 mm will be randomly assigned to standard surgery alone or surgery plus the…

This study compares two types of lasers (holmium:YAG and thulium fiber) used during a minimally invasive surgery to break up large kidney stones. About 150 adults with stones larger than 15 mm will be randomly assigned to one laser or the other. The goal is to see which laser wor…

This study compares two common surgeries for removing kidney stones: mini-PCNL (a small incision in the back) and flexible ureteroscopy with a special suction tube. About 80 adults with kidney stones between 1 and 3 cm will be randomly assigned to one procedure. The main goal is …

This study tests a new biodegradable stent (Hydrustent) that dissolves on its own after being placed in the ureter following kidney stone removal. The goal is to see if it keeps urine flowing safely and reduces the need for a second procedure to remove the stent. About 134 adults…

This study tests whether a nerve block called an erector spinae plane (ESP) block can reduce pain and the need for opioid painkillers after percutaneous nephrolithotomy, a surgery to remove large kidney stones. About 128 adults having this surgery will be randomly assigned to rec…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study tests a simple change during kidney stone surgery: actively suctioning the kidney to collapse it at the end of the procedure, instead of letting it drain naturally. Researchers want to see if this reduces pain and infection right after surgery. About 90 adults with kid…

This study compares two common treatments for kidney stones that are 1 to 2 centimeters in size. One treatment uses shock waves from outside the body to break up the stone, while the other uses a thin scope and laser through the urinary tract. Researchers will measure how complet…

This study tests whether placing the numbing drug bupivacaine into the bladder after kidney stone surgery can reduce pain and bladder spasms. About 116 adults will be randomly assigned to receive either the drug or a saltwater placebo. The goal is to see if this simple step impro…

This study aims to find out if people who get calcium oxalate kidney stones produce more oxalate in their bodies than healthy people. Researchers will compare 80 adults—some with a history of stones and some without—after they eat a special low-oxalate diet and take small amounts…

This study aims to find out if people who get calcium oxalate kidney stones absorb more oxalate from food than healthy people. Researchers will compare stone formers and healthy volunteers by having them eat special diets and measuring oxalate in urine, blood, and stool. The goal…

This study is testing a new ureteroscope that shows surgeons the pressure inside the kidney in real time during stone removal. Researchers want to see if having this information changes how surgeons operate and leads to better outcomes. The study will enroll 80 adults with large …

This study is testing whether a blood test that measures endotoxin levels can predict the risk of infection after a type of kidney stone surgery called percutaneous nephrolithotomy (PCNL). Researchers will enroll 150 adults scheduled for this surgery and measure their endotoxin l…