Icahn School Of Medicine At Mount Sinai

This study is testing whether a combination of two therapies can help patients with severe, long-term brain injuries regain consciousness and function. Fifteen participants will receive gentle electrical stimulation to the ear (vagus nerve stimulation) while using a robotic table…

This study aims to improve treatment options for Mal de Débarquement Syndrome (MdDS), a balance disorder that causes persistent rocking, swaying, or pulling sensations. Researchers are testing whether virtual reality goggles can make an existing therapy more accessible, and wheth…

This study is testing if a daily pill called Abrocitinib can help control eczema (atopic dermatitis) and patchy hair loss (alopecia areata) in people with Down Syndrome. It will enroll 56 participants aged 12 and older. The goal is to see if the treatment is safe and effective at…

This study is creating a registry to monitor the safety and effectiveness of a surgically implanted device that stimulates the vagus nerve to help people recover movement after a stroke. It will follow 40 adults with chronic stroke who are getting the device as part of their stan…

This study is testing a new, standardized microbial therapy called MTC01 against the current standard treatment, a fecal microbiota transplant (FMT), for people who keep getting repeat C. diff infections. It aims to see if the new treatment is as safe and effective as the stool t…

This study is testing whether an oral medication called reparixin can help control advanced myelofibrosis, a serious bone marrow cancer. It's for patients whose disease has worsened despite standard treatments or who cannot take those treatments. Researchers will measure if the d…

This study is testing whether a medication called dupilumab can help regrow hair in children and teenagers with moderate-to-severe alopecia areata, an autoimmune condition that causes hair loss. About 76 participants, aged 6 to 18, will receive either the drug or a placebo via in…

This study is testing whether giving women with bulimia nervosa real-time feedback about their brain activity while they eat can help them gain better control over their eating behaviors. Researchers will use a special wearable brain-scanning device during a single training sessi…

This study is testing whether a three-part treatment can help people with liver cancer become eligible for a liver transplant. It combines a targeted radiation treatment (Y-90) with two drugs (atezolizumab and bevacizumab) to try to shrink or control tumors. The goal is to either…

This study is testing whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can help people with opioid addiction stay off illicit drugs. It will involve 450 adults who are already receiving standard medication treatment (methadone or buprenorphine). Participants …

This small pilot study is testing whether morning light therapy can help reduce inflammation and improve symptoms in adults with ulcerative colitis who also have poor sleep. Participants will use a wearable device to track sleep and receive one hour of morning light therapy daily…

This study is testing a new training program that teaches people with borderline personality disorder (BPD) how to better manage their intense emotions. Researchers will work with 130 participants to see if learning specific thinking strategies can change brain activity and reduc…

This study compares two methods to prevent calcium oxalate kidney stones from returning after surgery. 80 patients at Mount Sinai West will be randomly assigned to receive either standard prevention treatment or personalized treatment based on detailed urine testing. Researchers …

This study is testing whether two existing HIV antiviral medications can help reduce the burden of symptoms for people living with Long Covid. Researchers will compare the drugs, taken daily for 90 days, against a placebo pill in 90 adult participants. The main goal is to see if …

This study is testing if rinsing the bowel segment used to create a new urine system with a common antiseptic (chlorhexidine) during and after bladder removal surgery can prevent infections. The goal is to see if this rinse helps keep the urine sterile and reduces the number of p…

This early-stage study is testing whether a supplement called lumbrokinase can improve overall health and reduce symptoms for people with three debilitating long-term conditions: Long Covid, chronic Lyme disease, and ME/CFS (chronic fatigue syndrome). The trial will enroll 120 ad…

This study is testing whether adding a psychological resilience program to standard biologic medication helps people with Crohn's disease achieve better long-term results. It will enroll 170 adults newly starting a biologic drug who have active Crohn's symptoms. The goal is to se…

This study is testing whether a special eating plan called the Metabolic Diet can help women who have recovered from anorexia nervosa maintain their healthy weight and avoid relapse. The diet focuses on higher fat and lower carbohydrate foods to help keep blood sugar levels stabl…

This study is testing a combination of three drugs given before surgery (prostate removal) for men with high-risk prostate cancer. The goal is to see if this treatment can shrink the tumor so much that very little cancer is left after surgery. The study will enroll 40 men whose c…

This study aims to find the safest and most effective dose of a new drug, sacituzumab govitecan, when combined with an existing chemotherapy drug, cisplatin. It is for women whose ovarian or endometrial cancer has returned but responded well to platinum-based chemotherapy in the …

This study is testing whether a combination of gentle brain stimulation and mental training can help people with cocaine addiction reduce their cravings. Researchers will enroll 120 adults with cocaine use disorder to receive either real or fake stimulation while practicing techn…

This study is testing whether therapy delivered through video calls can help teens and young adults who show early warning signs of psychosis. Researchers want to see if online group, family, or individual therapy can reduce symptoms, improve daily functioning, and possibly preve…

This study aims to find out if adding a blood-thinning pill helps prevent strokes and other blood clots in patients who develop a temporary irregular heartbeat after coronary artery bypass surgery. It will compare the benefits of preventing clots against the risk of serious bleed…

This study is testing whether a daily pill called ritlecitinib can help people with keloids—thick, raised scars that can be painful and itchy. The trial will see if the drug can prevent keloids from coming back after surgery and reduce symptoms in people who don't have surgery. A…

This study is testing whether following a specific brain-healthy diet, called the MIND diet, can help protect the brain and manage symptoms in people with multiple sclerosis (MS). 100 adults with MS will be randomly assigned to either follow the MIND diet for a year or continue t…

This study is testing if adding a peer coach to standard therapy helps teens with eating disorders and their parents. For 12 weeks, families will get either coaching for the teen or the parent, plus educational materials for the other. Researchers want to see if this extra suppor…

This study is testing whether adding a low-dose, inexpensive drug called methotrexate helps people with certain rare blood cancers. Researchers want to see if it safely reduces symptoms like enlarged spleen, fatigue, and abnormal blood cell counts when added to a patient's curren…

This is an early-stage study to see if a new drug called alnuctamab is safe and might help control lupus in people whose disease hasn't improved with standard treatments. The drug works by guiding the body's own immune cells to attack the harmful cells thought to drive lupus. The…

This study is testing whether the drug bimekizumab can help people with moderate-to-severe plaque psoriasis when other similar medications have not worked. It will involve 60 adults who previously tried and did not respond well to treatments targeting IL-17 or IL-23. Participants…

This study is testing a new, FDA-approved brain catheter system designed to drain fluid and blood from the brain after a severe bleed. It aims to see if this new system can clear blood faster and more safely than the standard catheters currently used. The research will involve 17…

This study is investigating whether problems with the vagus nerve contribute to gut issues and inflammation in people living with HIV. Researchers will test if a medication called pyridostigmine or gentle nerve stimulation can help. The goal is to find new ways to manage these co…

This study is testing a home-based coaching program to help adults with COPD better manage their condition. Health coaches will work with 300 participants, primarily from minority and low-income communities in New York City, to improve medication use, exercise, and spot early sig…

This study is testing a self-management program designed to help World Trade Center responders better control their asthma. The program teaches participants how to properly use their inhalers and manage their symptoms. Researchers will measure whether the program improves asthma …

This study is testing a new in-ear device called SeizEAR to see if it can safely and effectively monitor brain waves and detect seizures in people with epilepsy. Researchers will compare the device's readings to the standard method, which involves placing many electrodes on a per…

This study is testing if a small, wearable continuous glucose monitor (CGM) can be used to diagnose gestational diabetes. It will compare the CGM's readings to the standard glucose lab test in 150 pregnant women. The goal is to see if the simpler, wearable device is as accurate a…

This study is testing whether a simple 3 oz water sip test can safely screen for swallowing problems in patients with tracheostomy tubes. Researchers will compare this quick bedside test to the current, more complex gold-standard swallowing exams. The goal is to find a faster, ea…

This study is testing whether a new, more comfortable upright MRI scanner works as well as the standard enclosed MRI for detecting prostate cancer. Researchers will compare both types of scans in 550 men at risk for prostate cancer over about 5 years. The goal is to see if the up…

This study is testing a new, FDA-approved imaging device called the Histolog Scanner. It is used during prostate cancer surgery to quickly check if cancer cells are left at the edges of the removed tissue. The main goal is to see if this scanner can save surgeons at least 20 minu…

This study aims to see if data from a continuous glucose monitor worn during late pregnancy and after birth can predict who will have abnormal blood sugar results on the standard postpartum test. It involves 40 women who had gestational diabetes and are already using a specific g…

This study is testing whether a new type of PET scan can find aggressive prostate cancer better than the standard MRI scan in men who are being monitored instead of immediately treated. About 120 men with low-risk prostate cancer on active surveillance will get both the new PET s…

This study compares two standard procedures used to diagnose cancer when fluid builds up around the lungs. Researchers want to know if starting with a more invasive biopsy (pleuroscopy) leads to a faster diagnosis and quicker start of cancer treatment compared to starting with a …

This study is testing two different therapy programs to help female veterans who have experienced military sexual trauma or intimate partner violence, and who also have a history of brain injury. Researchers want to see which approach works better at helping participants manage t…

This study is testing if adding an anti-inflammatory drug (ketorolac) to the standard numbing shot (lidocaine) can better reduce pain for women undergoing a common uterine exam called hysteroscopy. It will compare the new combination shot to the standard shot alone in 60 women. T…

This pilot study is testing whether a community navigator can help Black and Latina women with metastatic breast cancer better access supportive care services. Participants will work with a trained navigator who helps connect them to resources and provides education. The study ai…

This study is testing the safety and feasibility of a non-invasive device that gently stimulates a nerve in the neck while teens with cerebral palsy do hand therapy. The goal is to see if this combination can help improve hand and arm function. The study will enroll about 10 adol…

This study compares two medications (epinephrine and dexmedetomidine) when added to spinal anesthesia during planned cesarean sections. Researchers want to see if one provides longer-lasting pain relief without more side effects. The trial involves 62 pregnant patients having sch…

This study is testing whether self-hypnosis software used with a virtual reality headset can help reduce chronic pain in people living with HIV. Researchers will enroll 25 adults with HIV who have experienced chronic pain for at least 90 days. The study will check if the software…

This study is testing if a personalized exercise program, guided by a FitBit and digital health tools, can help people with a common heart rhythm problem called atrial fibrillation (AFib) feel better. Researchers will enroll 120 adults with symptomatic AFib to see if this tech-su…

This study is testing whether a drug that blocks a specific immune signal (IL-6) can help improve the brain's reward system and reduce the loss of pleasure in adults with major depression. Up to 20 participants with depression and signs of immune system activation will receive th…

This study is testing a program designed to reduce stress and burnout for community health workers in New York City. About 168 workers will attend six online workshops over six months, learning skills like coping with fear and building social support. Researchers will measure cha…

This study is testing a new, non-drug device called the Sana Pain Reliever to see if it can reduce chronic pain in people with Post-treatment Lyme Disease. The device is a special mask with earbuds that pulses light and plays tones for 15-minute sessions at home. Researchers will…

This study is testing if a 12-week recreational ballet program can help children with autism. Researchers want to see if weekly dance classes improve motor skills, behavior, and mood. The study will enroll 32 children, ages 6 to 12, who have an autism diagnosis.

This study is testing whether music therapy can help children with depression. Twenty children will receive 11 weekly music therapy sessions. Half of the group will also attend special recitals to observe performers and discuss how sharing creativity affects their feelings and re…

This study is testing if a gentle, non-invasive device that stimulates a nerve in the ear can help teens with anorexia nervosa during their refeeding treatment. Over 4 weeks, researchers will compare the real stimulation to a fake (sham) version to see if it helps participants fe…

This study is testing whether a proven memory support system can be helpful for older Chinese Americans who have mild thinking and memory problems. Researchers are adapting the program for Mandarin and Cantonese speakers to see if it improves daily life and memory skills. The stu…

This study is testing whether magnetic stimulation of the brain can help people with misophonia, a condition where specific sounds cause intense irritation or anger. Researchers will use a non-invasive device to stimulate the parietal area of the brain in 60 participants. They wi…

This study is testing if a specific nerve block, given after heart surgery, can help control pain better. Researchers want to see if it reduces the need for strong opioid painkillers and lowers patients' pain scores. The study will involve 75 adults having planned heart surgery, …

This study is testing whether dronabinol, a medication derived from cannabis, can help reduce chronic pain and inflammation in adults with sickle cell disease. Researchers will compare dronabinol to a placebo (inactive pill) in 60 participants to see if it improves pain levels an…

This study is testing whether a new home-based palliative care program can improve comfort and quality of life for people with advanced dementia and reduce stress for their family caregivers. Researchers will compare the program to usual care for 300 patient-caregiver pairs in Ne…

This study aims to understand how antipsychotic medications affect pregnant women with serious mental illness and their babies. Researchers will follow 200 pregnant women who are either taking antipsychotics, other psychiatric medications, or no medication. They'll track the moth…

This study aims to understand how cannabidiol (CBD) affects the brain and body's response to stress. Researchers will examine 160 young adults who experienced childhood adversity, giving them either CBD or a placebo. The study measures brain activity, stress hormones, and anxiety…

This study aims to better understand multiple myeloma by analyzing the genetic makeup of tumors from 100 patients over two years. Researchers will use advanced sequencing techniques on blood and tumor samples collected during standard care procedures to identify genetic patterns …

This study aims to understand how environmental exposures, like certain chemicals, might affect thyroid cancer risk and how aggressive it becomes. Researchers will enroll 500 adults with thyroid nodules who are scheduled for surgery. They will collect small blood samples and use …

This study is testing whether looking at rhythmic, flashing lights can improve brain activity and memory in people with mild cognitive impairment. Twenty participants will have their brain waves measured while they watch different light patterns. The goal is to see if the lights …

This study aims to understand how blood sugar levels after a liver transplant affect a patient's recovery and the long-term success of the transplant. Researchers will have 40 recent liver transplant patients wear a small, hidden glucose monitor for 30 days after leaving the hosp…

This study aims to understand if tiny plastic particles in our environment affect gut bacteria and inflammation, potentially increasing the risk for Crohn's disease and other bowel conditions. Researchers will analyze stool samples from pregnant women with Crohn's, healthy women,…

This research study aims to understand the biological and genetic causes of fibromuscular dysplasia (FMD) and two related artery conditions. Researchers will collect blood and tissue samples from 600 people with these conditions and healthy volunteers. By comparing these samples,…

This study aims to understand how eating and fasting affect brain function related to self-control in people with bulimia nervosa. Researchers will use brain scans and smartphone surveys to see how the brain's control circuits work differently after a meal. The goal is to learn w…

This study aims to understand how the antibiotic vancomycin affects the community of bacteria in the gut and the immune system in people with multiple sclerosis (MS). Researchers will give vancomycin to 12 newly diagnosed, untreated MS patients and track changes in their gut bact…

This early-stage study is testing whether a combination of exercise, a dietary supplement (spermidine), and one of two drugs (rapamycin or lamivudine) is safe and feasible for older adults who smoke or used to smoke. The main goal is to see if participants can stick to the regime…

This study is creating a large registry of people with pancreatic diseases or who are at high risk for pancreatic cancer. Researchers will collect health information and blood samples from participants to learn how family history, genetics, and other factors contribute to disease…

This study aims to understand how depression changes the brain's reward system. Researchers will record brain activity from 10-24 epilepsy patients who are also being monitored for depression while they play a simple gambling game. The goal is to identify specific brain patterns …

This study aims to understand if social isolation contributes to the poorer physical health and shorter lifespan often seen in people with schizophrenia. Researchers will follow 650 people, including 500 with schizophrenia and 150 of their siblings, to see how social connections …

This study aims to track 1,500 people with rare porphyria blood disorders over many years to better understand how the diseases progress, how treatments work, and what affects patients' quality of life. Researchers will collect health information, lab results, and genetic data to…

This study is testing two new types of brain scan software from Siemens to see if they are useful for surgeons. The goal is to help doctors see brain bleeds more clearly during and after a minimally invasive surgery to remove them. Researchers will collect scans from about 15 adu…

This study is testing whether telling women about a specific finding on their mammogram—calcifications in breast arteries—helps them take steps to improve their heart health. Researchers will enroll over 5,700 women to measure how common this finding is. Then, they will tell some…

This study aims to understand how eating a lot of fructose (a common sugar) changes the bacteria in your gut and affects your metabolic health, including liver fat and diabetes risk. Researchers will have 30 adults who poorly absorb fructose follow two different 12-day diets—one …

This study aims to better understand the brain activity and thinking patterns behind obsessive-compulsive disorder (OCD). Researchers will use brain scans (EEG) and computer models to compare 50 adults with OCD to 50 healthy adults. The goal is to gather detailed information that…

This study aims to understand if pulse oximeters, the clip-on devices that measure blood oxygen, are equally accurate for children with different levels of skin pigmentation. It will observe 92 pediatric patients with congenital heart disease who are already scheduled for heart s…

This study is creating a large registry of patients with immune system diseases who are receiving biologic medications as part of their standard care. Researchers will collect health information and samples from about 800 participants to better understand how these treatments wor…