Icahn School Of Medicine At Mount Sinai

This trial tests whether removing a brain bleed with a minimally invasive scope within hours of symptoms improves recovery. 300 adults with a specific type of brain bleed will be randomly assigned to either get the surgery plus standard care, or standard care alone. The study wil…

This study looks at whether adding a blood thinner to standard antiplatelet therapy helps prevent strokes and blood clots in people who develop a new, temporary irregular heartbeat after coronary artery bypass surgery. About 3,200 adults who had bypass surgery and then experience…

This study tests whether using a hemostatic agent (a substance that stops bleeding) during kidney stone surgery can reduce blood loss compared to standard care. About 92 adults with kidney stones will be randomly assigned to receive either a hemostatic agent or no agent during th…

This study tests a personalized version of deep brain stimulation (DBS) for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Researchers will adjust the stimulation to target specific brain circuits linked to each patient's sympto…

This pilot study tests whether the steroid prednisone can prevent recurrent pleural effusions (fluid buildup around the lungs) in people with non-specific pleuritis. Forty adults will be randomly assigned to take prednisone daily for 4 weeks or receive no steroid. The study lasts…

This study compares two psychological treatments for adolescents aged 12-18 with anorexia nervosa: a new approach called Interoceptive Exposure Therapy (IE) versus standard Family Based Therapy (FBT). IE helps teens face food-related fears by pairing feared foods with positive ex…

This early-stage study tests whether MDMA (the active ingredient in ecstasy) combined with talk therapy can help people with bulimia nervosa. Forty adults will be assigned to one of three groups: MDMA with general therapy, MDMA with bulimia-specific therapy, or standard treatment…

This phase 2 trial tests a combination of hormone therapy (Lupron), an androgen blocker (Darolutamide), and an immunotherapy (Pembrolizumab) given before and after prostate removal surgery in 40 men with high-risk prostate cancer. The goal is to see if this approach can reduce or…

This study tests a daily pill called deucravacitinib in 20 adults with two types of scarring hair loss (CCCA and FFA). The goal is to see if it can reduce inflammation and scarring on the scalp over 48 weeks. All participants receive the drug, and researchers will measure changes…

This pilot study tests a topical cream called delgocitinib in 30 adults with two types of scarring hair loss: lichen planopilaris and central centrifugal cicatricial alopecia. Participants apply the cream twice daily for 48 weeks. The study focuses on safety and changes in immune…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether a low dose of sirolimus (rapamycin), a drug that calms the immune system, can help adults with Long COVID feel better. Eighty participants will take either sirolimus or a placebo pill once a week for 12 weeks. The main goal is to see if the drug improves …

This study is testing a device that sends mild electrical pulses to the vagus nerve in the neck, paired with physical therapy, to help people who had a stroke months or years ago. The goal is to see if this approach can safely improve arm and leg movement. About 40 adults with ch…

This phase 2 study tests the drug reparixin in 10 people with myelofibrosis, a type of bone marrow cancer. Participants have advanced disease and cannot take or have not responded to standard JAK inhibitor therapy. They take reparixin pills three times daily for 6 months, with th…

This study is testing a special catheter called IRRAflow that both drains fluid and actively irrigates the brain to remove blood after a hemorrhage. The trial will compare this device to standard catheters in 17 adults with intraventricular hemorrhage. Researchers want to see if …

This early-stage trial is testing a new drug, alnuctamab, in 21 people with moderate to severe lupus that hasn't improved with standard treatments. The drug is given as an injection under the skin, and participants will stay in the hospital for 9 days after the first dose. The ma…

This study looks at whether community health workers can help emergency department patients with high blood pressure connect to local resources that address their social needs, like food or housing. Fifteen adults with uncontrolled hypertension will complete surveys and receive r…

This study tests two drugs, abemaciclib and bicalutamide, together in people with a type of metastatic breast cancer that has spread and is positive for androgen receptors but negative for HER2. The goal is to find the safest dose and see if the combination can control the diseas…

This study tests whether combining two drugs (atezolizumab and bevacizumab) with a type of internal radiation (Y-90) can shrink liver tumors enough for patients to become eligible for a liver transplant. About 40 adults with hepatocellular carcinoma (HCC) will receive this combin…

This study tests a 'Metabolic Diet' designed to help women with anorexia nervosa maintain a healthy weight after they have regained weight. Twenty adult women who recently reached a normal weight will follow the diet with a dietitian's help for 10 weeks. Researchers will monitor …

This study tests if dupilumab can help children aged 6 to 17 with moderate to severe alopecia areata regrow hair. About 76 participants will receive either the drug or a placebo for 48 weeks, followed by an open-label extension. The main goal is to measure changes in scalp hair l…

This study tests a daily pill called abrocitinib for people with Down syndrome who have eczema or a type of hair loss. About 56 participants will take the drug for up to 60 weeks to see if it safely controls their skin or scalp condition. The goal is to manage symptoms, not cure …

This study tests if rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after bladder cancer surgery can prevent urinary tract infections. About 23 adults having bladder removal and reconstruction will participate. The main goal is to see if urine is…

This study tests low-dose methotrexate, a common arthritis drug, in 54 people with three rare blood cancers: polycythemia vera, essential thrombocythemia, and myelofibrosis. Researchers want to see if it can shrink spleens, improve symptoms, and lower blood counts safely. If succ…

This phase 3 trial tests whether adding cannabidiol (CBD) to standard opioid addiction treatment can reduce cravings and prevent relapse. About 450 adults with opioid use disorder who are already on methadone or buprenorphine will receive CBD or a placebo for 24 weeks. The goal i…

This study tests a combination of two drugs, sacituzumab govitecan and cisplatin, in people with ovarian or endometrial cancer that has come back but still responds to platinum-based treatments. The goal is to find the safest dose and see how well the drugs shrink tumors. About 5…

This study tests whether adding a structured coping skills program to standard biologic medication improves emotional well-being and disease remission in people with early Crohn's disease. 170 adults with active Crohn's for less than 5 years will receive either the coping program…

This study is testing whether a simple, standard prevention plan works as well as a personalized one for people who get calcium oxalate kidney stones. 80 participants will either receive a diuretic and diet advice based on their stone type alone, or have their treatment guided by…

This study tests two treatments for people with repeat C. diff infections: a lab-made bacteria mix called MTC01 and a fecal transplant (FMT) from a healthy donor. Both are given during a colonoscopy. The goal is to see which is safer and better at stopping the infection from comi…

This study tests whether following the MIND diet—rich in olive oil, fish, vegetables, and whole grains—for one year can protect brain health and reduce symptoms in people with multiple sclerosis. One hundred participants will be randomly assigned to either the diet or continue th…

This study tests whether personalized home-based coaching can help people with COPD better manage their symptoms and avoid hospital visits. Researchers will enroll 300 adults from diverse backgrounds in New York City. Participants will receive support from health coaches, includi…

This study tests whether the drug ritlecitinib can prevent keloids from returning after surgical removal. Keloids are raised, often itchy scars that grow beyond the original wound. The trial will enroll 30 adults who will take a daily pill for 36 weeks. Researchers will measure k…

This study tests a new way to check for bleeding after stroke surgery using a special ultrasound through a clear skull implant. It aims to see if this method is as accurate as a CT scan, which is the current standard but is expensive and time-consuming. About 25 adults who had a …

This study is testing whether adding a special PET scan (using a radioactive tracer called flotufolastat F18) to the standard MRI can better find aggressive prostate cancer in men who are currently on active surveillance. About 120 men with low- or favorable intermediate-risk pro…

This pilot study will enroll 150 pregnant individuals to see if a continuous glucose monitor (CGM) can accurately diagnose gestational diabetes. Participants will wear a small sensor on their arm that measures blood sugar continuously. The results will be compared to the standard…

This study tests whether an upright MRI (where you sit) can detect prostate cancer as well as the standard closed MRI and PSA blood test. About 550 men at risk for prostate cancer will get both types of MRI and answer comfort questionnaires. The goal is to see if the upright MRI …

This study is testing a small device that fits in the ear to detect seizures by measuring brain waves. Researchers will first test it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the in-ear device i…

This study tests a new FDA-approved device called the Histolog Scanner, which takes high-resolution images of the prostate surface right after it is removed during surgery. The goal is to see if this faster method can save more than 20 minutes compared to the standard lab process…

This study is testing whether a simple 3-ounce water swallow test can accurately detect aspiration (liquid entering the airway) in people with tracheostomies. Researchers will compare the results of this quick bedside test with the current gold-standard methods (a camera through …

This pilot study tests whether combining a gentle nerve stimulator placed on the ear (taVNS) with robotic tilt-table therapy can safely help people with prolonged disorders of consciousness after severe brain injury. Fifteen participants will undergo 12 weeks of paired therapy, a…

This study is testing whether the immunotherapy drug pembrolizumab can improve quality of life for people with advanced non-small cell lung cancer who are not healthy enough for standard treatments. The trial will enroll 45 patients who have not had prior cancer therapy and have …

This study tests whether carefully timed lighting can help multiple myeloma patients undergoing their first stem cell transplant. Two hundred participants will receive either bright morning light and dim evening light, or dim light all day. Researchers will measure sleep quality,…

This study tests whether a non-invasive procedure called vestibulocortical stimulation (VCS) can reduce pain and improve quality of life in people with fibromyalgia. VCS involves gently irrigating the ear canal with temperate water using a plastic syringe. The trial will compare …

This study tests whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique already used for depression, can help people with misophonia tolerate trigger sounds. Sixty adults will each receive two TMS sessions (one inhibitory, one excitatory) targ…

This study tests two different ways of positioning patients during surgery for stones in the upper part of the ureter. One position uses a slight head-down tilt to keep stones from moving back into the kidney, while the other tilts the patient to help clear stones from the kidney…

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner has early-stage dementia. The program is designed to help both partners manage emotional distress after a recent diagnosis. The study will include 24 couples and …

This study is testing whether a special flickering light therapy can improve memory and sleep in people with mild cognitive impairment or early Alzheimer's disease. About 120 participants will be randomly assigned to one of four light conditions and use the light at home for two …

This study tests a type of talk therapy called Meaning-Centered Psychotherapy for Caregivers (MCP-C) to see if it helps cancer caregivers feel more purpose and less distress. About 200 caregivers of people with advanced cancer will be randomly assigned to MCP-C or standard suppor…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study tests a device called the Sana Pain Reliever, a mask with earbuds that delivers pulses of light and sound for 15 minutes at a time. Researchers want to see if it can reduce chronic pain and improve sleep in people with post-treatment Lyme disease syndrome. The trial in…

This study tests whether adding suzetrigine, a new non-opioid pain drug, to standard pain management can lower the amount of opioids needed after weight-loss or heart surgery. About 235 adults will be randomly assigned to receive either suzetrigine or a placebo alongside usual ca…

This study tests whether giving a low dose of ephedrine right after an epidural can prevent abnormal fetal heart rate patterns in laboring women. About 100 women requesting labor pain relief will receive either ephedrine or a placebo. The goal is to see if ephedrine reduces the c…

This study tests whether tocilizumab, a drug that blocks inflammation, can help people with major depression who have lost interest or pleasure in things (anhedonia). About 20 adults with depression and signs of immune activation will receive the drug for 8 weeks, while 20 health…

This Phase 3 trial tests whether Suzetrigine, a new pain medication, can improve pain control and reduce opioid use after total knee replacement. About 235 adults scheduled for knee surgery will be randomly assigned to receive either Suzetrigine or a placebo, in addition to stand…

This study tests a virtual reality (VR) headset that uses circadian reset technology to improve sleep and reduce binge eating in 40 adults with binge eating disorder. Participants use the headset for 10 minutes twice daily for one month. Researchers will compare changes in binge …

This study is testing a self-hypnosis program that runs on a virtual reality headset to help people with HIV manage chronic pain. About 25 adults with HIV and long-term pain will use the software at home for 21 days. Researchers will check if it is safe, easy to use, and if it he…

This study tests whether two HIV antiviral drugs, Truvada and Selzentry, can reduce symptoms in adults with Long COVID. Researchers think hidden viral activity may cause ongoing symptoms. 90 participants will take one of the drugs or a placebo daily for 90 days, and their health …

This study tests whether one hour of morning light therapy each day for four weeks can improve sleep quality and reduce inflammation in adults with ulcerative colitis who have active inflammation and poor sleep. Thirty participants will wear a sleep tracker, complete surveys, and…

This small safety trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can safely improve hand and arm function in 10 adolescents with spastic cerebral palsy. Participants will use the device during upper limb rehabilitation sessions. The main…

This study tests a dietary supplement called lumbrokinase in 120 adults with Long Covid, post-treatment Lyme disease syndrome, or ME/CFS. Participants take the supplement daily for 6 weeks. The goal is to see if it improves overall health and quality of life, as measured by a sim…

This study tests whether a gentle brain stimulation technique (tDCS) combined with cognitive training can reduce cravings in people with cocaine addiction. 120 participants will receive either real or sham stimulation for 20 minutes a day, three times a week, for five weeks. Rese…

This study tests a virtual reality therapy for Mal de Débarquement Syndrome (MdDS), a balance disorder causing persistent rocking or swaying sensations. Two hundred participants will undergo five days of treatment using VR to retrain their balance system. The goal is to improve s…

This study tests a noninvasive brain-training technique called neurofeedback in 30 women with bulimia nervosa. Using a wearable headband that measures brain activity, participants receive real-time feedback while eating to improve self-control. The goal is to see if this training…

This study is testing whether cognitive behavioral therapy (CBT) delivered via telehealth can help young people aged 14 to 25 who are at clinical high risk for psychosis. Participants will receive group, family, or individual CBT sessions online. The goal is to see if this approa…

This study tests a web-based program called webSTAIR, which teaches emotion regulation and relationship skills, for female veterans who have experienced military sexual trauma or intimate partner violence and also have a brain injury. The goal is to see if it helps them manage em…

This study tests a new type of mental training for people with borderline personality disorder (BPD). The training teaches a skill called 'reappraisal-by-distancing' to help control emotions. Researchers will use brain scans to see if the training changes brain activity and will …

This pilot study tests a program called ACCESS, where a community navigator helps Black and Latina women with metastatic breast cancer connect to supportive care and community resources. Participants receive six coaching sessions and monthly check-ins over 16 weeks. The goal is t…

This study tests whether adding ketorolac (an anti-inflammatory) to the standard lidocaine numbing shot can reduce pain during office hysteroscopy, a procedure to look inside the uterus. Sixty women with abnormal bleeding will be randomly assigned to get either the combo or lidoc…

This study explores whether music therapy can help children with depression build resilience and ease symptoms. Twenty children will attend 11 music therapy sessions, with some also attending recitals to discuss performance anxiety and self-expression. The goal is to see if these…

This study tests a non-invasive device that stimulates the vagus nerve before meals in teens and young adults (ages 14-22) with anorexia or similar eating disorders. Over 4 weeks, participants receive either real or sham stimulation to see if it boosts meal satisfaction, calorie …

This study tests whether adding a peer coach or parent coach to standard eating disorder therapy helps teens aged 12-18 recover faster. 70 participants will receive 12 weeks of therapy plus either a parent coach with patient education materials or patient coaching with parent edu…

This study tests whether dronabinol, a drug made from cannabis, can reduce chronic pain and inflammation in adults with sickle cell disease. About 60 participants will receive either dronabinol or a placebo to see if it improves pain and quality of life. The goal is to find a new…

This study tests whether a rectus sheath block, a type of nerve block using local anesthetic, can reduce pain and the need for opioid painkillers after cardiac surgery. Researchers will compare opioid use and pain scores in 75 adults who receive the block versus those who do not.…

This study looks at how stress from stereotypes affects impulsivity and alcohol use in African Americans. Researchers will use fMRI brain scans to measure brain activity while participants do tasks that involve everyday stress. The goal is to understand the link between social st…

This study aims to uncover the biological basis of fibromuscular dysplasia (FMD) and related artery conditions like spontaneous coronary artery dissection (SCAD) and cervical artery dissection (CvAD). Researchers will analyze genetic and molecular data from 600 participants, incl…

This study is observing 300 women with female sexual organs who are receiving radiotherapy for certain cancers. Researchers want to understand why some patients have more sexual side effects than others. They will track sexual quality of life and look at radiation doses to find p…

This observational study follows 74 pregnant individuals with severe mental illness to see how taking antipsychotics (versus other medications or no medication) affects psychiatric stability and infant development. Participants complete psychiatric interviews, donate blood, and h…

This study looks at how things in the environment, like chemicals, might affect how thyroid cancer grows. Researchers will collect blood samples and have participants fill out questionnaires. They hope to find patterns that could explain why some thyroid cancers are more aggressi…

This observational study follows 170 people with multiple sclerosis, neuromyelitis optica, and similar conditions, plus healthy volunteers, for up to 6 years. Researchers use MRI scans, blood tests, and spinal fluid analysis to monitor brain lesions and understand how the disease…

This study uses functional MRI to measure oxygen levels in arm muscles and deeper tissues when pressure is applied and when the muscle contracts. Healthy volunteers wear a brace with a blood pressure cuff and lift a 10-pound weight during scanning. The goal is to see if MRI can r…

This study looks at people who have changes in a gene called FOXP1, which can cause developmental delays, speech problems, and autism-like traits. Researchers will use interviews, play-based assessments, and genetic tests to better understand these conditions. The goal is to lear…

This study tests whether offering rapid point-of-care testing for gonorrhea and chlamydia helps more teens get HIV testing and PrEP. About 6,460 adolescents aged 16-24 will be compared: some get rapid testing, others get standard lab testing. The goal is to see if same-day result…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This study tests two new Siemens imaging prototypes during minimally invasive surgery to remove brain bleeds. The tools aim to detect leftover bleeding and measure blood flow in the brain. Researchers will compare the prototype images with standard CT scans to see if they are use…

This study tests whether community health workers and special training for doctors can help more kidney patients get on the transplant waitlist. Five patients will be assigned to either usual care or extra support from a community health worker who addresses social needs like hou…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study looks at whether the amount of vitamin D in your blood affects your chance of developing thyroid problems while receiving immunotherapy for cancer. Researchers will measure vitamin D and thyroid function before and during standard cancer treatment. The goal is to see i…

This study looks at how educational workshops can reduce stress and burnout and improve resilience in community health workers and frontline workers in New York City. About 168 participants will take surveys before and after the program. The goal is to learn what works best to su…

This study looks at whether social isolation contributes to the early health problems seen in people with schizophrenia, who often die 10–20 years earlier than others. Researchers will follow 650 participants (500 with schizophrenia and 150 siblings) aged 40–70, tracking medical …

This study looks at how eating changes brain activity related to self-control in women with bulimia nervosa. Researchers will use MRI scans to compare brain responses after fasting versus after a meal. The goal is to understand why control breaks down, leading to cycles of bingei…

This study looks at how damage to the vagus nerve may cause gut issues and inflammation in people with HIV. Researchers will test two approaches—a drug called pyridostigmine and non-invasive vagus nerve stimulation—to see if they can improve gut function and reduce inflammation. …

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study looks at whether pulse oximeters—the clips placed on fingers to measure oxygen levels—work equally well for children with different skin tones who have congenital heart disease. Researchers will enroll 92 children under 18 undergoing heart surgery and compare the oxime…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study compares two ways to diagnose cancer in people with fluid buildup around the lungs (pleural effusion). One method, thoracentesis, drains the fluid with a needle. The other, pleuroscopy, uses a tiny camera to look inside and take tissue samples. Researchers want to see …

The PLANET study is looking at whether tiny plastic particles in our environment can trigger gut inflammation and raise the risk of inflammatory bowel disease (IBD). Researchers will measure microplastics in stool samples from pregnant women, their healthy relatives, and people w…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for type 2 diabetes and fatty liver. Thirty adults with obesity, diabetes, or fatty liver will eat a high-fructose or high-glucose diet for 12 days, then swit…

This study looks at how cannabidiol (CBD) influences stress in 160 people aged 18-25 who experienced early life trauma. Participants receive either CBD or a placebo, then undergo brain scans and stress tests. The goal is to understand the brain and hormone changes behind CBD's st…

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how blood sugar control relates to complications like wound healing or other transplant outcomes. Participants m…

This study tests a memory support program for Chinese American adults aged 55 and older with mild cognitive impairment (MCI). The program, originally designed for English speakers, will be adapted for Mandarin and Cantonese speakers. The goal is to see if the program is practical…

This study uses brain wave recordings (EEG) and computer models to better understand why people with OCD feel compelled to repeat certain actions. Researchers will compare 50 adults with OCD to 50 healthy volunteers. The goal is to find more precise brain patterns linked to compu…

This study aims to understand how the brain processes rewards in people with depression. Researchers will record brain activity from epilepsy patients who also have depression while they play a gambling task. The goal is to identify abnormal brain signals that could guide future …

This early-stage study tests whether combining exercise, a natural supplement called spermidine, and either rapamycin or lamivudine is safe and doable for current or former smokers aged 65-80. The goal is to see if this mix can reduce inflammation and slow aging. Only 22 particip…

This study will analyze the genetic makeup of tumors from 100 people with relapsed multiple myeloma. Researchers will use advanced DNA and RNA sequencing to find genetic changes and understand how the cancer works. The goal is to gather information that could guide more personali…

This study looks at whether continuous glucose monitors (CGMs) worn during late pregnancy and for two weeks after birth can predict which women with gestational diabetes will have abnormal blood sugar after delivery. Currently, only a small percentage of women complete the standa…

This study is testing whether the antibiotic vancomycin can change the gut bacteria and immune system of people with newly diagnosed multiple sclerosis (MS). The researchers will give vancomycin or a placebo to 12 people and measure changes in gut bacteria, blood markers, and bra…