Sugar shock: could fructose be wrecking your gut and raising diabetes risk?
NCT ID NCT06329544
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for type 2 diabetes and fatty liver. Thirty adults with obesity, diabetes, or fatty liver will eat a high-fructose or high-glucose diet for 12 days, then switch after a break. Researchers will measure changes in gut bacteria, blood markers, and liver fat to understand the link between sugar, the microbiome, and metabolic disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Fructose (dietary supplement)
What this could lead to
If successful, this study could reveal how excess fructose harms metabolic health through gut microbiome changes, pointing to new dietary or microbiome-based strategies to reduce diabetes risk.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. It is designed to understand mechanisms, not to test a treatment, so no direct health benefit is expected.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mount Sinai Morningside
RECRUITINGNew York, New York, 10025, United States
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