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Sugar shock: could fructose be wrecking your gut and raising diabetes risk?

NCT ID NCT06329544

Recruiting now Knowledge-focused Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for type 2 diabetes and fatty liver. Thirty adults with obesity, diabetes, or fatty liver will eat a high-fructose or high-glucose diet for 12 days, then switch after a break. Researchers will measure changes in gut bacteria, blood markers, and liver fat to understand the link between sugar, the microbiome, and metabolic disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Fructose (dietary supplement)
What this could lead to
If successful, this study could reveal how excess fructose harms metabolic health through gut microbiome changes, pointing to new dietary or microbiome-based strategies to reduce diabetes risk.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. It is designed to understand mechanisms, not to test a treatment, so no direct health benefit is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fatty liver disease metabolic dysfunction-associated steatotic liver disease Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MASLD OBESITY TYPE 2 DIABETES

Contacts and locations

Locations

  • Mount Sinai Morningside

    RECRUITING

    New York, New York, 10025, United States

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