MASLD

This study tests whether a low dose of digoxin, a drug normally used for heart problems, can help people with a severe type of fatty liver disease called NASH (also known as MASH). About 144 adults with confirmed NASH and liver scarring will take digoxin or a placebo for a period…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study aims to see if advanced ultrasound techniques can accurately detect fatty liver disease in children without the need for invasive biopsies or costly MRI scans. Researchers will enroll 120 children aged 9 to 18 who have risk factors for the condition. The new ultrasound…

This study is testing a small, portable device called LiverScope that uses MRI-like technology to check for liver disease without needles or surgery. About 26 adults with fatty liver disease (MASLD or NAFLD) will have their liver scanned with LiverScope and compared to a standard…

This study looks at how the liver responds to sugar in people with obesity, both with and without a liver condition called MASLD. During planned bariatric surgery, participants receive either a sugar solution or salt water through a vein. Small tissue samples from the liver and f…

This study is testing a new way to measure liver stiffness and fat using an endoscope with ultrasound (EUS-SWE). It will compare this method to standard liver biopsy and FibroScan in 300 adults with suspected liver disease. The goal is to see if this new technique can accurately …

This study looks at how much oxalate the body naturally makes in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a type of fatty liver. About 28 adults with MASLD will eat a low-oxalate diet and provide urine samples to measure oxalate levels. The go…

This study tests a new care pathway to help primary care doctors better diagnose and treat NAFLD, a common liver disease in Veterans linked to obesity and diabetes. The pathway automatically identifies at-risk patients and educates providers. Researchers will compare this approac…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This study aims to find genetic differences that make some people with fatty liver disease develop severe liver damage or cancer. Researchers will analyze DNA from blood and liver tissue of 2880 adults with advanced disease and compare it to controls. The goal is to create better…