MASLD

This study is testing if digoxin, a medication used for heart conditions, can help treat a serious liver disease called NASH (now called MASH). Researchers will give 144 people with NASH either digoxin or a placebo pill daily for 24 weeks to see if it reduces liver inflammation a…

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This study is testing a new, step-by-step care system designed to help VA primary care teams better identify and manage fatty liver disease (NAFLD) in Veterans. It compares this new system to usual care to see if it leads to more diagnoses and better follow-up treatment. The goal…

This study aims to see if a new type of ultrasound, done during a standard scope procedure, can accurately measure liver scarring (fibrosis) and fat without needing a painful biopsy. It will enroll 300 adults who are already scheduled for both a liver biopsy and a FibroScan test …

This study is testing new ultrasound analysis techniques to detect and measure fatty liver disease in children without invasive procedures. Researchers will enroll 120 children aged 9-18 who have risk factors for fatty liver disease. They'll compare the accuracy of these new ultr…

This study aims to understand if a common liver condition (MASLD) changes how much oxalate the body makes on its own. Oxalate is a natural substance that, in high amounts, can contribute to kidney stones. Researchers will measure this by having 28 participants follow a special lo…

This study aims to understand why some people with fatty liver disease develop serious liver damage, like cirrhosis or cancer, while others do not. Researchers will analyze the complete DNA of 2880 participants, comparing people with advanced disease to those with only risk facto…

This study aims to understand how the liver responds to sugar in people with obesity who are having weight-loss surgery. Researchers will compare 40 patients with and without fatty liver disease (MASLD), giving some a sugar solution and others salt water during surgery, then taki…

This study aims to understand how eating a lot of fructose (a common sugar) changes the bacteria in your gut and affects your metabolic health, including liver fat and diabetes risk. Researchers will have 30 adults who poorly absorb fructose follow two different 12-day diets—one …