Sugar test during surgery may unlock secrets of fatty liver disease

NCT ID NCT07326865

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looks at how the liver reacts to a sugar injection during bariatric surgery in people with obesity, comparing those with and without fatty liver disease (MASLD). Forty adults will receive either a sugar solution or salt water during surgery, and small tissue samples will be taken to measure changes in gene activity. The goal is to understand why MASLD develops and how the liver handles sugar, which could lead to better ways to diagnose or treat the condition.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
labeled glucose (intravenous)
What this could lead to
If successful, this study could reveal how the liver processes sugar differently in people with MASLD, pointing toward new ways to understand or treat the disease.
What could go wrong
This is a small, early-stage observational study (40 participants) that does not test a treatment. Results may not apply to broader populations or lead directly to therapies.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • AMC

    RECRUITING

    Amsterdam, North Holland, 1105AZ, Netherlands

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