Old heart drug could be new hope against fatty liver

NCT ID NCT06588699

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a low dose of digoxin, a drug normally used for heart problems, can help people with a severe type of fatty liver disease called NASH (also known as MASH). The trial will involve 144 adults with biopsy-confirmed NASH and liver scarring. Participants will take either digoxin or a placebo daily for a period, and researchers will check if the drug can reverse liver inflammation and scarring without worsening the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: digoxin
What this could lead to: If it works, this could provide a new, repurposed treatment option for NASH/MASH, especially for patients with liver fibrosis.
What could go wrong: This is an early Phase 2 trial with only 144 participants. Digoxin is a heart medication, and its safety and effectiveness for liver disease are not yet proven. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver fatty liver disease metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FATTY LIVER DISEASE FATTY LIVER DISEASE, NONALCOHOLIC MASH MASH - METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS MASH WITH FIBROSIS MASLD NAFLD NASH

Contacts and locations

Locations

Yale New Haven Health
RECRUITING

New Haven, Connecticut, 06510, United States
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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