NAFLD

This study looks at how much exercise works best to lower liver fat in people with nonalcoholic steatohepatitis (NASH), a serious liver condition. Researchers will enroll 45 sedentary adults aged 18-69 with NASH and early-stage liver scarring. Participants will follow different e…

This study tests whether a low dose of digoxin, a drug normally used for heart problems, can help people with a severe type of fatty liver disease called NASH (also known as MASH). About 144 adults with confirmed NASH and liver scarring will take digoxin or a placebo for a period…

This study looks at whether adding different exercise programs to a Mediterranean diet can lower inflammation better than diet alone in adults aged 18-65 with obesity and non-alcoholic fatty liver disease (NAFLD). About 90 participants will be assigned to diet only, diet plus one…

This study tests whether a daily dose of nicotinamide (a form of vitamin B3) can stop or reverse liver scarring (fibrosis) in people with fatty liver disease. Thirty overweight or obese adults with liver scarring will take either nicotinamide or a placebo for one year. Researcher…

This study tests whether bicalutamide, a drug that blocks male hormones, can improve liver health in women with both PCOS and fatty liver disease. About 50 women aged 18-42 will receive either the drug or a placebo for a short time. The goal is to see if it reduces liver fat and …

This study compares two step-by-step strategies to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both strategies start with a simple blood test, then use a more advanced test only if needed, to avoid invasive liver biopsies. About 1,045 participants…

This study is testing a small, portable device called LiverScope that uses MRI-like technology to check for liver disease without needles or surgery. About 26 adults with fatty liver disease (MASLD or NAFLD) will have their liver scanned with LiverScope and compared to a standard…

This study uses tiny, lab-grown liver models called organoids to understand how a specific gene change (PNPLA3 I148M) contributes to non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. Researchers will create these models from liver cells donated by 60 ad…

This study looks at why people born with low birth weight are more likely to develop fatty liver disease (NAFLD). Researchers will put 8 adults with NAFLD on a 4-week low-calorie diet to see if it reduces liver fat. The goal is to understand how the body stores fat and whether th…

This study looks at how androgens (a type of sex hormone) might affect fatty liver disease in young women. Researchers will compare women with PCOS (who often have high androgen levels) to those without PCOS. The goal is to understand changes in liver fat and stiffness over time.…

This study tests a new care pathway to help primary care doctors better diagnose and treat NAFLD, a common liver disease in Veterans linked to obesity and diabetes. The pathway automatically identifies at-risk patients and educates providers. Researchers will compare this approac…

This study looks at whether blocking two proteins, SUV420H1 and SUV420H2, in liver cells can protect against nonalcoholic fatty liver disease (NAFLD). Researchers will test this in mice on a fatty diet, analyze human genetic data from large health databases, and try a new approac…

This study looks at how genes influence fatty liver disease and related heart and blood clot problems. Researchers will study 2500 blood donors aged 40-65 who are overweight or have related health issues. The goal is to use genetic information to better predict who is at risk and…