NAFLD

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2…

This early-stage study tests whether bicalutamide, a drug that blocks male hormones, can improve liver health in women aged 18-42 who have both polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). About 50 participants will receive either bicalutamide or…

This study tests whether a low dose of digoxin, a drug normally used for heart problems, can help people with a severe type of fatty liver disease called NASH (also known as MASH). The trial will involve 144 adults with biopsy-confirmed NASH and liver scarring. Participants will …

This study tests whether a 4-week ketogenic diet before liver surgery can reduce fat in the liver and lower the need for blood transfusions. About 124 adults with fatty liver and colorectal cancer that spread to the liver will either follow the diet or get standard dietary advice…

This study looks at whether adding aerobic or high-intensity interval exercise to a low-glycemic Mediterranean diet can lower inflammation better than diet alone. Researchers will enroll 90 adults aged 18-65 with obesity and non-alcoholic fatty liver disease. Participants will be…

This phase 2 trial tests whether nicotinamide (a form of vitamin B3) can stop or reverse liver fibrosis in people with non-alcoholic fatty liver disease and obesity. Thirty adults will take either nicotinamide or a placebo daily for one year. Researchers will measure liver stiffn…

This study aims to find the most effective amount of exercise to reduce liver fat in people with NASH, a serious liver disease. Researchers will compare different exercise doses in 45 sedentary adults aged 18-69 with NASH and early-stage liver scarring. The goal is to provide cle…

This study is testing a new, portable device called LiverScope that uses magnetic fields to check the liver for disease, similar to an MRI but smaller and easier to use. Researchers want to see if LiverScope gives the same results as a standard MRI. About 26 adults with a type of…

This study compares two step-by-step approaches to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both methods start with a simple blood test, then use a more advanced test only if needed, aiming to avoid invasive liver biopsies. About 1,045 particip…

This study tests whether semaglutide (a drug used for diabetes and weight loss) can prevent weight gain and fatty liver disease in people who have recently had a liver transplant. About 50 adults who had a transplant 2 to 6 months ago will receive either semaglutide or a placebo.…

This study looks at whether a 4-week low-calorie diet can reverse fatty liver disease in people who were born with low birth weight. Researchers will compare them to people born at normal weight, using MRI scans to measure liver fat before and after the diet. Only 8 participants …

This study looks at how androgens (a type of sex hormone) might affect fatty liver disease in young women. Researchers will compare changes in liver fat and stiffness over time in 150 women with and without PCOS. The goal is to understand the connection, not to test a treatment.

This study looks at how certain gene regulators, called SUV420H1/2, affect fatty liver disease (NAFLD). Researchers will analyze data from 260 people and use lab models to see if blocking these genes could reduce liver fat and damage. The goal is to find a new way to treat this c…

This study uses tiny, lab-grown liver models (organoids) made from patient cells to understand how a specific gene variant (I148M of PNPLA3) contributes to non-alcoholic steatohepatitis (NASH), a serious fatty liver disease. Researchers will expose these mini-livers to fatty acid…

This study looks at how genetic factors influence the risk of liver damage and heart problems in people with fatty liver disease. Researchers will enroll 2,500 blood donors aged 40-65 who are overweight or have related conditions like high blood sugar or high cholesterol. The goa…

This study tests a new care pathway for non-alcoholic fatty liver disease (NAFLD) in VA primary care. The pathway automatically identifies at-risk patients and educates providers. Researchers will compare this approach to usual care in 32 primary care teams to see if it increases…