NAFLD

This pilot study tested a drug called ibutamoren in 12 adults with nonalcoholic fatty liver disease (NAFLD). The goal was to see if it could lower fat in the liver. Participants took the drug for 6 months, and researchers measured liver fat using a special MRI. The study is compl…

This study looked at 36 adults with obesity and non-alcoholic fatty liver disease (NAFLD). Participants followed one of two low-calorie Mediterranean diet plans, with different amounts of carbs and fats, plus a moderate exercise program. After 3 months, researchers checked liver …

This study tested a new medicine called DD01 in 67 overweight or obese adults with a type of fatty liver disease (MASLD/MASH). The goal was to see if DD01 could reduce liver fat by at least 30% over 48 weeks compared to a placebo. The trial also checked safety and other liver hea…

This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. Thirty adults with biopsy-confirmed fibrosis took the drugs or a placebo for 21 weeks. The main go…

This study tested a new medicine called efinopegdutide in 381 adults with nonalcoholic steatohepatitis (NASH), a serious fatty liver disease that can lead to cirrhosis. The main goal was to see if the drug could reverse signs of liver inflammation without making scarring worse. R…

This study looked at 60 girls with obesity and polycystic ovarian syndrome (PCOS). They were given either a weekly semaglutide injection or a special diet for 12 weeks. The goal was to see which approach better reduced liver fat and improved how the body uses insulin. The results…

This study looked at whether adding tomatoes to the diet can improve liver health, gut function, and blood sugar in people with non-alcoholic fatty liver disease (NAFLD). 80 adults with NAFLD and a BMI of 30 or less took part. Researchers measured liver fat, inflammation, and gut…

This study tested a drug called elobixibat in 47 adults with nonalcoholic fatty liver disease (NAFLD) or its more serious form, NASH. The goal was to see if the drug could lower bad cholesterol (LDL-C) compared to a placebo over 16 weeks. The trial also checked for side effects. …

This study looked at whether two blood tests, eLIFT and FibroMeter, can accurately detect advanced liver fibrosis (scarring) in people with type 2 diabetes. The researchers compared these blood tests to a specialized ultrasound (FibroScan) and, in some cases, liver biopsy. The go…

This completed study looked at how people with chronic liver disease (like hepatitis B, C, or fatty liver) respond to COVID-19 vaccines. Researchers measured antibody levels and tracked COVID-19 infections over 6 months in 233 adults. The goal was to see if liver disease severity…

This study gathered information from over 1,000 people with non-alcoholic fatty liver disease (NAFLD) to improve non-invasive tests for liver scarring. Currently, doctors often need to take a small sample of liver tissue (biopsy) to check for damage, which is uncomfortable and ri…

This study looked at the financial impact of non-alcoholic fatty liver disease (NAFLD) on 73 adults in Flanders, Belgium. Researchers measured healthcare costs and patient expenses using detailed questionnaires. The goal was to understand the economic burden of the disease, not t…

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and produce sugar. Researchers studied 21 people with obesity, type 2 diabetes, and fatty liver disease to understand if the liver becomes resistant to glucagon. The goal was to learn…

This study tested new MRI and MRE scans that let children breathe normally during the exam, instead of holding their breath. The goal was to see if these free-breathing scans can accurately measure liver fat and stiffness in kids with fatty liver disease. About 135 children took …

This study tracked 317 adults with type 2 diabetes to see how many have fatty liver disease and how severe it gets over time. Researchers used advanced MRI scans to measure liver fat, inflammation, and scarring. Participants were checked twice, three years apart, to find who had …

This study looked at 292 people with non-alcoholic fatty liver disease (NAFLD) to see if the amount of scarring in the liver is linked to heart disease risk. Researchers used painless imaging tests to measure liver stiffness and coronary calcium. The goal was to better understand…