NAFLD

This study is testing whether empagliflozin, a medication for diabetes, can prevent or slow the progression of liver scarring (fibrosis and cirrhosis) in people with chronic hepatitis B. The 106 participants are already taking standard antiviral drugs but still have significant l…

This study is testing if placing a temporary balloon in the stomach helps people with fatty liver disease. It aims to see if this procedure helps patients lose weight and improves their liver health over at least one year. The study will enroll 200 obese adults who are already sc…

This study is testing if an 8-week, very low-calorie meal replacement diet can reduce harmful fat and scarring in the livers of people with obesity and non-alcoholic fatty liver disease (NAFLD). Researchers will compare 10 people on the special diet to 10 others on a standard low…

This study is testing whether an investigational drug called efinopegdutide can help treat a serious form of fatty liver disease called MASH that has progressed to cause permanent scarring (cirrhosis). About 80 adults with this condition will receive either the drug or a placebo …

This study aimed to test a new type of ultrasound device for detecting and measuring fat in the liver. Researchers planned to compare the device's accuracy to the current standard method, an MRI scan. The trial was withdrawn before any participants were enrolled.

This study is testing new MRI and ultrasound scanning methods to accurately measure fat in children's livers. It involves 24 children, both with obesity and with a healthy weight, to see if these scans are practical and reliable. The goal is to improve the tools doctors use to de…

This study is testing a new portable device called LiverScope® to see if it can accurately measure fat in the liver. Researchers are comparing it to standard MRI scans and another ultrasound test in 50 adults with or suspected of having fatty liver disease. The goal is to see if …

This study aims to understand how the hormone glucagon works in the liver and how this process might be different in people with obesity, type 2 diabetes, or fatty liver disease. Researchers will measure how the body processes amino acids with and without glucagon in a small grou…

This study aims to find out how common fatty liver disease is in people who have type 2 diabetes. Researchers at a hospital in Belgium will use a special scan to check the livers of 385 adult patients with diabetes. The goal is to gather information to better understand the link …

This study aims to understand how common fatty liver disease is in people living with HIV. Researchers will enroll 1,250 participants to measure liver fat and collect health information. The goal is to identify risk factors and fill a major knowledge gap, as previous large studie…

This study aims to understand how fatty liver disease develops and progresses in people living with HIV. Researchers will follow 400 participants for at least one year, using non-invasive scans to measure liver fat and stiffness. The goal is to fill critical knowledge gaps about …