Can a Two-Drug cocktail reverse liver scarring? early trial hints at possibility
NCT ID NCT05506488
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and fibrosis. Thirty adults with biopsy-confirmed liver scarring took either the drug combo or a placebo in cycles over 21 weeks. The goal was to see if the treatment improved fibrosis by at least one point on a standard scoring system without worsening other liver damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dasatinib and quercetin
- What this could lead to
- If it works, this could point toward a treatment that reduces liver scarring in people with fatty liver disease, potentially preventing progression to cirrhosis.
- What could go wrong
- This is a very small, early-phase study with only 30 participants. The results may not apply to everyone, and the treatment could cause side effects like nausea or low blood counts.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Amsterdam UMC location AMC
Amsterdam, Netherlands
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Other studies related to the condition(s) this trial covers.
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