Fibrotic liver disease

This phase 3 trial tests survodutide, a weekly injection, in 1800 adults with MASH and moderate to advanced liver fibrosis. Participants receive either the drug or a placebo for up to 7 years, alongside diet and exercise advice. The goal is to see if survodutide can improve or re…

This trial compares two approaches for treating advanced metabolic dysfunction-associated steatohepatitis (MASH), a serious liver condition linked to obesity. About 120 adults with MASH and liver fibrosis will be randomly assigned to either metabolic surgery (gastric bypass or sl…

This study tests an experimental drug called AZD2389 in about 104 adults with fatty liver disease and advanced liver scarring (fibrosis). The drug is a pill that blocks a protein linked to scarring. Researchers will check if it safely lowers markers of liver damage over 24 weeks …

This study tests whether taking a low dose of niacin (vitamin B3) after meals can help reduce fat stored in the liver for people with metabolic fatty liver disease (MASLD). Researchers will compare niacin to a placebo in 36 adults aged 50 to 80. The goal is to see if niacin can r…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study looks at whether drinking instant coffee every day for 6 weeks can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 adults who completed surgery, chemo, or radiation at least 2 months ago will par…

This study tests whether copper supplements can improve liver function and safety in people with cirrhosis who have low copper levels. Researchers will give 30 participants either copper or a placebo and measure changes in blood copper levels and other health markers. The goal is…

This study tests whether a low dose of the thyroid hormone Synthroid can help treat nonalcoholic steatohepatitis (NASH), a serious liver condition common in Veterans. About 128 overweight or obese Veterans with NASH will take either Synthroid or a placebo daily for one year. The …

This study tests whether phycocyanin, a natural protein from spirulina, can improve liver health in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks. Researchers will measure changes in liver stiffness …

This phase 2 trial tests whether nicotinamide (a form of vitamin B3) can stop or reverse liver fibrosis in people with non-alcoholic fatty liver disease and obesity. Thirty adults will take either nicotinamide or a placebo daily for one year. Researchers will measure liver stiffn…

This study tests if a tube-like device called a stent, placed through a scope, can reverse gastric bypass surgery in 20 people who have serious complications like low blood sugar, blockages, or liver problems. The goal is to see if the stent works as well as surgery to fix these …

This study tests whether taking atorvastatin (Lipitor) daily for 48 weeks can reduce the risk of liver cancer in 60 adults with advanced liver fibrosis or cirrhosis. Participants are randomly assigned to receive either the drug or a placebo. The main goal is to see if atorvastati…

This early-stage trial is testing a new drug called PHIN-214 (a modified version of terlipressin) in 74 adults with mild-to-moderate liver cirrhosis. The study has two parts: a single dose and then daily injections for 28 days. The main goals are to check safety, find the best do…

This study is testing a new ultrasound technique called visual transient elastography (ViTE) to measure liver fat and scarring in people with chronic liver injury. Researchers will compare the ultrasound results to the standard liver biopsy to see how accurate the new method is. …

This study aims to see which of two blood tests, eLIFT or FibroMeter, is better at finding advanced liver scarring (fibrosis) in people with fatty liver disease or alcohol-related liver disease. About 1,788 adults from primary care clinics will take both tests. The goal is to imp…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study tests a new endoscopic ultrasound method (EUS-SWQ) to measure liver stiffness and diagnose liver fibrosis (scarring) in people with chronic liver disease. Researchers will compare EUS-SWQ results with standard liver biopsy and FibroScan in 65 adults. The goal is to see…

This study is testing a new, non-invasive ultrasound device called the Hepatoscope to screen for liver scarring (fibrosis) and fatty liver in people at risk. Researchers will enroll 200 patients with risk factors like diabetes or elevated liver enzymes. Those with high stiffness …

This study compares two newer imaging methods—photon-counting CT and ultrasound—against the standard MRI to see how well they detect fat and scarring in the liver. About 45 adults with liver disease will receive all three scans. The goal is to find a faster, cheaper, and equally …

This study tests a new, fast MRI technique that measures collagen in the liver to detect scarring (fibrosis) without a needle biopsy. Researchers will compare the MRI results with standard tests in 200 adults with liver disease and healthy volunteers. The goal is to find a safer,…

This study looks at whether magnetic resonance elastography (MRE), a special type of MRI, can accurately measure liver scarring (fibrosis) in people with chronic hepatitis B. Researchers will compare MRE results to standard liver biopsies in 600 adults. If MRE works well, it coul…

This study is testing whether combining new blood tests and stool analysis can detect liver fibrosis earlier than current methods. Researchers will follow 1200 adults referred to a community liver clinic. The goal is to identify advanced liver disease sooner and reduce unnecessar…

This study is testing a new way to measure liver scarring using an endoscopic ultrasound with special software. About 300 adults with suspected liver disease will undergo this new scan, a standard liver biopsy, and another non-invasive test. The goal is to see if the new techniqu…

This study aims to find undiagnosed cases of advanced liver fibrosis and viral hepatitis B and C in the general population of Seine Saint Denis, France. Using a combination of rapid diagnostic tests and a portable liver stiffness scanner (FibroScan), researchers will screen 600 a…

This study will screen 2,000 people with HIV for fatty liver disease using a painless ultrasound technique. The goal is to catch liver problems early and improve long-term care. Researchers will also track how different HIV medications affect liver health.

This study is testing a two-step screening method to find advanced liver fibrosis in people who don't yet have symptoms. First, a routine blood test calculates a score called FIB-4. If that score is high, patients get a more specialized non-invasive test. The goal is to see how w…

This study is looking for new blood markers that could show how much scarring (fibrosis) is in the liver of people with chronic liver disease. Researchers will compare these markers to current tests like FibroScan and liver biopsy. The goal is to find a more accurate and less inv…

This study aims to understand how liver diseases like fatty liver, hepatitis B, fibrosis, and cirrhosis develop by analyzing individual liver cells and their spatial organization. Researchers will collect blood and discarded liver tissue from 240 patients undergoing surgery or bi…

This study looks at a program where family doctors work with a hospital to find liver scarring (fibrosis) early in people at risk. About 150 adults with a high FIB-4 score will get a special liver scan (Fibroscan). The goal is to see if those with scarring get the right follow-up…

This study looks at how the drug bulevirtide changes gut bacteria and bile acids in people with hepatitis delta (a serious liver infection). Researchers will follow 20 patients for 48 weeks, collecting stool and blood samples to see how these changes relate to liver health. The g…

This study looks at using liver elastography, a non-invasive ultrasound-like technique, to measure liver fibrosis in children with type III glycogen storage disease (GSDIII). The goal is to see if this method can replace painful liver biopsies for monitoring disease progression. …