Could a tiny dose of thyroid hormone heal fatty liver disease?
NCT ID NCT05526144
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a low dose of the thyroid hormone Synthroid can help treat nonalcoholic steatohepatitis (NASH), a serious liver condition common in Veterans. About 128 overweight or obese Veterans with NASH will take either Synthroid or a placebo daily for one year. The goal is to see if the hormone improves liver fat breakdown and reduces liver damage and scarring.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Synthroid (levothyroxine, a thyroid hormone)
What this could lead to
If it works, this could provide a new, well-tolerated treatment option for NASH, potentially slowing or reversing liver damage in Veterans.
What could go wrong
This is an early phase 2 trial with only 128 participants, so results may not apply broadly. The treatment may not improve liver health, and there are risks from thyroid hormone dosing, though doses are low and monitored.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Harry S. Truman Memorial, Columbia, MO
RECRUITINGColumbia, Missouri, 65201-5275, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••