LIVER FIBROSIS

This study is testing whether a natural protein from spirulina algae, called phycocyanin, can help treat liver scarring (fibrosis and cirrhosis). Researchers will give the supplement or a placebo to 10 adult patients for at least 4 weeks to see if it reduces liver stiffness and l…

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This study is testing whether a low dose of thyroid hormone can treat a serious form of fatty liver disease called NASH in Veterans. Researchers believe the hormone may help the liver's energy centers burn excess fat more effectively. The trial will compare the hormone against a …

This is a first-in-human study to test the safety and dosing of a new drug called PHIN-214 in adults with liver cirrhosis. The drug is given as a shot under the skin and is designed to reduce high blood pressure in the liver's portal vein, which may help improve kidney function. …

This study is testing whether a weekly injection called survodutide can improve liver health in adults with MASH, a serious fatty liver disease that causes scarring. About 1,800 participants will be randomly assigned to receive either the real medicine or a placebo (dummy shot) f…

This study is testing whether a special type of MRI scan, called magnetic resonance elastography (MRE), can accurately measure liver scarring (fibrosis) in people with chronic Hepatitis B. The goal is to find a better, non-invasive way to monitor the disease over time, potentiall…

This study is testing a new, very fast type of MRI scan designed to detect early liver scarring (fibrosis) without the need for a painful biopsy. Researchers will compare the scan's results to both the current gold-standard biopsy and another non-invasive scan in 200 adults with …

This study is testing a new system to help family doctors find liver scarring (fibrosis) earlier in patients at risk from alcohol, obesity, or diabetes. It connects primary care clinics with a hospital to provide a special scan (Fibroscan) for patients with a high initial blood t…

This study aims to understand how various liver conditions, like fatty liver disease, hepatitis B, and liver scarring, develop and progress. Researchers will analyze blood and small pieces of leftover liver tissue from 240 patients who are already having surgery or a biopsy for t…

This study aims to create better prediction tools for liver disease in people living with HIV. Researchers will follow 320 HIV-positive participants for 5 years to understand how fatty liver disease and liver scarring develop and progress. The goal is to build models that can ide…

This early-stage study aims to see if an experimental oral drug, AZD2389, reaches and engages its intended target in the livers of people with advanced liver scarring (fibrosis). Researchers will use special PET scans to measure this in about 12 participants. The main goal is to …

This study is looking at whether a painless ultrasound scan (elastography) can reliably measure liver scarring in children and young adults with a rare genetic disorder called Glycogen Storage Disease Type III (GSDIII). Researchers will review the medical records of 30 patients w…