LIVER FIBROSIS

This study tests whether a low dose thyroid hormone can help Veterans with NASH, a serious liver disease linked to obesity and diabetes. The goal is to see if the hormone improves the liver's ability to break down fat and reduces liver damage. About 128 participants will receive …

This study tests a medicine called survodutide, given as a weekly injection, in 1800 adults with MASH (a fatty liver disease) and moderate to advanced liver scarring. The goal is to see if it can improve or reverse liver damage without worsening scarring. Participants are randoml…

This study tests an experimental drug called PHIN-214 in 74 adults with mild-to-moderate liver cirrhosis (Child-Pugh A or B). The goal is to find a safe dose and see how the body handles the drug. It is an early-phase trial focused on safety, not a cure.

This study tests whether phycocyanin, a natural protein from spirulina, can reduce liver damage and stiffness in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks, with regular blood tests and ultrasound…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests a new, fast MRI method to measure liver scarring (fibrosis) without needing a needle biopsy. The scan takes less than 8 seconds while you hold your breath. Researchers will compare the new MRI results with standard tests in 200 adults to see if it can catch early…

This study looks at whether magnetic resonance elastography (MRE), a special type of MRI, can accurately measure liver scarring (fibrosis) in people with chronic hepatitis B. Researchers will compare MRE results to standard liver biopsies in 600 adults. If successful, MRE could o…

This study looks at a new way for family doctors to find early liver scarring (fibrosis) in people at risk, like those with diabetes or heavy alcohol use. About 150 adults who had a special liver scan will be followed to see if they get the right care afterward. The goal is to se…

This early-stage study tests whether a single dose of the experimental drug AZD2389 can bind to a protein called FAP in the liver, which is linked to scarring. Twelve adults with advanced liver fibrosis will receive the drug and then have a PET scan to measure changes. The goal i…

This study looks at 320 people with HIV to create tools that predict who might develop fatty liver disease or liver scarring. The goal is to catch these problems early so doctors can help sooner. Participants will have regular check-ups and liver scans over time.

This study looks at liver tissue and blood from 240 people with various liver conditions, including fatty liver, hepatitis B, fibrosis, and cirrhosis. Researchers will use advanced cell analysis to map how liver cells change and interact as disease progresses. The goal is to find…

This study looks at using a special ultrasound (liver elastography) to measure liver scarring in children with type III glycogen storage disease, a rare condition that can lead to serious liver problems. Researchers will review past elastography results from 30 participants aged …