New injection aims to tame liver Scarring—First human trial underway

NCT ID NCT05490888

Recruiting now Disease control Sponsor: PharmaIN Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-stage trial is testing a new drug called PHIN-214 (a modified version of terlipressin) in 74 adults with mild-to-moderate liver cirrhosis. The study has two parts: a single dose and then daily injections for 28 days. The main goals are to check safety, find the best dose, and see how the body processes the drug. It is not yet testing whether the drug actually improves liver health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PHIN-214 (a terlipressin derivative given as a subcutaneous injection)
What this could lead to: If successful, this could point toward a new treatment option to manage cirrhosis and reduce complications like fluid buildup (ascites).
What could go wrong: This is an early phase 1 trial with only 74 participants, focused on safety and dosing—not yet testing effectiveness. The drug may cause side effects or not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ASCITES HEPATIC are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Ascites cirrhosis of liver Fibrosis fibrotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASCITES HEPATIC CIRRHOSIS, LIVER LIVER FIBROSIS

Contacts and locations

Show contact details

Locations

Arizona Liver Health
RECRUITING

Chandler, Arizona, 85224, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Methodist Health System, Dallas Medical Center
RECRUITING

Dallas, Texas, 75203, United States

Contact Email: •••••@•••••
Southern California Research Center
RECRUITING

Coronado, California, 92118, United States
Tandem Clinical Research
RECRUITING

Marrero, Louisiana, 70072, United States
Texas Liver Institute
RECRUITING

San Antonio, Texas, 78215, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
VA North Texas Healthcare System
RECRUITING

Dallas, Texas, 75216, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.