CIRRHOSIS, LIVER

This early-stage study is testing the safety of an investigational drug called siplizumab in patients with autoimmune liver disease who are receiving a liver transplant. The drug is given right after surgery to help prevent the body's immune system from attacking the new liver. U…

This early-stage trial is testing whether specially designed mixtures of helpful gut bacteria are safe for people hospitalized with serious liver disease. Researchers want to see if these bacterial mixtures can restore a healthier gut environment, which is often damaged in liver …

This is the first study in people to test a new personalized cell therapy called RTX001 for advanced liver disease. The therapy is made by collecting a patient's own white blood cells, engineering them in a lab to potentially reduce liver scarring and inflammation, and then retur…

This study is testing a new, personalized guidance system for giving IV fluids to patients with advanced liver disease who develop sudden kidney injury. Researchers will compare this new system against the standard albumin treatment to see which is safer, more effective, and easi…

This study is testing whether an intensive monitoring program helps people with cirrhosis and fluid buildup stay healthier after leaving the hospital. Patients receive a digital scale, educational materials, weekly check-in calls, and early follow-up appointments. Researchers wil…

This study is testing whether a special amino acid supplement can help reverse muscle loss in people with liver cirrhosis. Muscle wasting is a common and serious complication that worsens health outcomes. Researchers will compare the supplement to a placebo over 3 months to see i…

This study is testing whether a cholesterol-lowering drug called rosuvastatin can safely slow the progression of liver cirrhosis. It will involve about 256 adults with early-stage cirrhosis who are not yet experiencing severe complications. Participants will take either the drug …

This is a first-in-human study to test the safety and dosing of a new drug called PHIN-214 in adults with liver cirrhosis. The drug is given as a shot under the skin and is designed to reduce high blood pressure in the liver's portal vein, which may help improve kidney function. …

This study is testing whether a combination of two immunotherapy drugs (tremelimumab and durvalumab) is safe and effective for people with advanced liver cancer who also have moderately impaired liver function, known as Child-Pugh B cirrhosis. It focuses on including patients fro…

This study is testing whether a special nutritional supplement containing the amino acid leucine can help rebuild lost muscle in people with liver cirrhosis. Muscle loss is a common and serious problem in cirrhosis that increases the risk of complications. Researchers will compar…

This study is comparing two ways to give fluids and medications to liver patients with severe, life-threatening infections (sepsis). One method uses a bedside heart ultrasound to carefully guide treatment, while the other follows a standard protocol. The goal is to see if the ult…

This study is testing a new type of MRI scan to see if it can accurately measure high blood pressure in the liver, a serious complication of cirrhosis. The goal is to create a safer, non-invasive alternative to the current standard test, which requires inserting a catheter into a…

This study is testing a new type of MRI scan to find swollen, fragile veins in the esophagus and stomach of people with advanced liver disease (cirrhosis). These veins can burst and cause fatal bleeding. The goal is to see if this non-invasive scan can accurately identify high-ri…

This study aims to see how well a diagnostic scoring system, called the HScore, works for identifying a dangerous immune system overreaction (HLH) in critically ill patients. It will look back at the medical records of 100 adult patients with liver problems who were treated in an…

This study aims to develop a simple, non-invasive breath test to help diagnose liver cirrhosis earlier. Researchers will give participants a safe drink containing food additives and analyze their breath to see if changes in metabolism can reveal liver damage. The goal is to creat…

This study is testing whether a compound from green tea (EGCG) can help prevent liver cancer in people with cirrhosis, a serious liver scarring condition. Sixty participants with a high risk of developing cancer will take either the green tea extract or a placebo pill for 24 week…

This study aims to understand if high pressure inside the belly is linked to more fluid from the stomach getting into the lungs of critically ill patients with liver cirrhosis who are on breathing machines. Researchers will monitor belly pressure and test fluid from patients' bre…

This study aims to understand how a hepatitis D treatment called bulevirtide affects gut bacteria and bile acids in patients. Researchers will follow 20 patients with hepatitis D and liver damage, collecting samples over 48 weeks to see how these gut factors change during treatme…

This study aims to understand how different types of exercise affect muscle loss in people with cirrhosis, a serious liver condition. Researchers will compare 12 weeks of supervised endurance cycling to supervised resistance training in 40 participants. The goal is to learn which…

This study aims to understand the non-medical challenges, like financial strain or housing issues, that people with chronic liver disease face. Researchers will survey 400 patients and their doctors at Indiana University to see how common these problems are and whether patients w…