CIRRHOSIS, LIVER

This study tests whether rosuvastatin, a cholesterol-lowering drug, can safely slow or stop liver scarring (cirrhosis) compared to a placebo. About 256 adults with compensated cirrhosis will take the drug or placebo for 2 years. The main goal is to measure changes in liver stiffn…

This study tests whether a 12-week online program of exercise, nutrition advice, and behavioral support can improve physical function in adults with cirrhosis who are waiting for a liver transplant. About 177 participants from six Canadian transplant centers will be randomly assi…

This study tests a volume assessment guidance algorithm (VAGA) to help doctors decide how much and what type of IV fluid to give cirrhosis patients with acute kidney injury. Fifty hospitalized adults with cirrhosis and kidney injury will be randomly assigned to receive either VAG…

This pilot study tests an intensive monitoring program for people with cirrhosis and severe swelling (fluid overload) after they leave the hospital. Participants receive a digital scale, educational materials, weekly phone calls, and a follow-up appointment with a liver specialis…

This study tests a new treatment called RTX001 for people with severe liver scarring (cirrhosis) that has led to complications. RTX001 uses the patient's own immune cells, modified in a lab to reduce inflammation and scarring. The trial will enroll 30 adults to check if the thera…

This study tests a combination of two immunotherapy drugs (tremelimumab and durvalumab) in 32 people with advanced liver cancer who also have moderate cirrhosis (Child-Pugh B). The main goal is to see if the treatment is safe and tolerable, and to measure how well it shrinks tumo…

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This study tests whether a special mix of amino acids with HMB can help reverse muscle loss in people with cirrhosis. Muscle loss is common in cirrhosis and can make patients weaker and increase risks before and after liver transplant. The trial will give participants either the …

This early-stage trial is testing whether giving a mix of healthy gut bacteria (from donors) to people hospitalized with serious liver disease is safe and tolerable. The study involves 24 adults with liver failure or cirrhosis who have low levels of certain gut metabolites. Resea…

This study tests whether a leucine-enriched essential amino acid mixture can reverse muscle loss (sarcopenia) in people with liver cirrhosis. Researchers will give 32 participants either the active mixture or a placebo for 3 months, measuring muscle protein production and overall…

This early-stage trial is testing a new drug called PHIN-214 (a modified version of terlipressin) in 74 adults with mild-to-moderate liver cirrhosis. The study has two parts: a single dose and then daily injections for 28 days. The main goals are to check safety, find the best do…

This study is testing whether a new type of MRI (4D flow MRI) can detect dangerous veins in the stomach and esophagus of people with cirrhosis, which can cause fatal bleeding. Currently, doctors use a camera down the throat (endoscopy) to check, but that is invasive and often unn…

This study is testing whether a special MRI scan called 3D-MRE can accurately detect high blood pressure in the liver (portal hypertension) caused by cirrhosis or advanced liver disease. Currently, doctors use an invasive catheter procedure (HVPG) to measure this pressure. The st…

This study is testing whether a special drink (EVOC probe) can help detect liver cirrhosis by measuring chemicals in a person's breath. Researchers will compare breath samples from 240 people with and without cirrhosis to build a risk model. The goal is to develop a simple, non-i…

This study tests whether a green tea compound called EGCG can lower the risk of liver cancer in people with cirrhosis. Researchers will give EGCG or a placebo to 60 adults with cirrhosis and no history of liver cancer. The goal is to see if EGCG reduces a biomarker linked to canc…

This study tests a home monitoring program called LiverWatch for people with advanced liver disease (cirrhosis). Participants get a Fitbit, personalized nutrition advice, and weekly check-ins to boost activity and manage symptoms. The goal is to see if this approach improves qual…

This study follows 60 adults with cirrhosis who are waiting for a liver transplant but do not have diabetes. Researchers want to see if tests like glucose monitoring, oral glucose tolerance tests, and wrist activity trackers can predict who will develop diabetes after the transpl…

This study is recruiting 710 adults with fatty liver disease or alcohol-related liver disease, with or without cirrhosis, to understand why some develop liver cancer. Researchers will analyze genetic markers, immune factors, and imaging data from routine liver biopsies and blood …

This study looks at how the drug bulevirtide changes gut bacteria and bile acids in people with hepatitis delta (a serious liver infection). Researchers will follow 20 patients for 48 weeks, collecting stool and blood samples to see how these changes relate to liver health. The g…

This study looks at whether a tool called the HScore can accurately diagnose hemophagocytic lymphohistiocytosis (HLH) in intensive care patients with liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to one hospital over ten years who had …

This study looks at whether high pressure in the belly (intra-abdominal hypertension) causes more fluid to leak into the lungs in people with severe liver disease who are on breathing machines. Researchers will measure fluid markers in the windpipe and track complications like pn…

This study compares two ways to manage fluids in cirrhosis patients with severe sepsis or septic shock. One method uses a bedside heart ultrasound (POCUS) to guide fluid amounts, while the other follows standard sepsis guidelines. The goal is to see if ultrasound-guided care redu…

This study looks at how 12 weeks of endurance or resistance exercise affects muscle loss and ammonia buildup in people with cirrhosis. Cirrhosis can cause the liver to fail at processing ammonia, leading to muscle wasting and confusion. Researchers will compare two types of home-…

This study looks at the social and economic challenges faced by people with chronic liver disease, like trouble paying for food or housing. Researchers will survey 400 patients and their doctors at Indiana University Health to find out what needs are most common and how patients …