Can a simple supplement reverse muscle wasting in liver disease?
NCT ID NCT05166499
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a special mix of amino acids with HMB can help reverse muscle loss in people with cirrhosis. Muscle loss is common in cirrhosis and can make patients weaker and increase risks before and after liver transplant. The trial will give participants either the HMB-enriched supplement or a balanced amino acid mix for 3 months and measure changes in muscle protein synthesis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hydroxy Methyl Butyrate (HMB) and essential amino acids
What this could lead to
If it works, this could point toward a treatment to reverse muscle loss in cirrhosis, potentially improving quality of life and outcomes before and after liver transplant.
What could go wrong
This is a small, early-phase study with only 24 participants, so results may not apply to everyone. The supplement may not significantly improve muscle mass or function.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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