The Cleveland Clinic

This study is testing whether a topical cream called ruxolitinib is safe and effective for treating severe skin symptoms in adults with dermatomyositis, an autoimmune disease. The cream is being studied in 15 participants whose skin symptoms have not improved with other standard …

This study is testing if a special type of cycling, where a machine helps you pedal, can improve recovery of arm and leg movement after a stroke. Researchers will compare this forced cycling plus standard rehab against standard rehab alone in 66 stroke survivors. They also want t…

This study is testing if a weekly weight-loss medication called Tirzepatide can help people with obesity and a heart rhythm disorder called atrial fibrillation. About 100 participants will receive either Tirzepatide or a placebo for 12 months to see if losing weight leads to bett…

This study compares two versions of a minimally invasive kidney stone removal surgery. Researchers want to see if using a vacuum-assisted tube works better than a standard tube for removing medium-sized stones. About 90 patients will have their surgery and recovery tracked to mea…

This study is testing whether taking a protein supplement at bedtime and again in the early morning can help people with advanced liver disease stay out of the hospital. It focuses on patients who have recently been hospitalized for a condition called hepatic encephalopathy, whic…

This study compares two methods to help food move properly from the stomach after surgery to remove the esophagus (esophagectomy). Researchers want to see if injecting Botox into a stomach valve works as well as a standard surgical cut (pyloromyotomy) at preventing uncomfortable …

This early-stage study is testing whether a supplement called HA35 can help people with alcoholic hepatitis. Over 90 days, 54 participants will take either HA35 or a placebo pill while researchers measure changes in muscle mass, gut health, and overall condition. The goal is to s…

This study is testing whether a special amino acid supplement can help reverse muscle loss in people with liver cirrhosis. Muscle wasting is a common and serious complication that worsens health outcomes. Researchers will compare the supplement to a placebo over 3 months to see i…

This study is comparing two techniques for removing large, flat colon polyps to see which is better at preventing them from growing back. Adults with polyps at least 20mm wide will have one of the removal methods and return for a follow-up check in 3-6 months. The goal is to find…

This study follows patients who received the Triathlon Hinge Knee System, a specialized implant for complex knee surgeries. Researchers will track how well the knee replacements hold up over 1, 2, 6, and 10 years, looking for factors that lead to success or failure. The goal is t…

This small pilot study is testing whether using a CPAP machine for sleep apnea can help reduce episodes of atrial fibrillation (Afib) and improve quality of life. Twenty participants with both conditions will alternate between using and not using their CPAP machine for two-week p…

This study is testing a new type of clinic designed to diagnose and treat muscle loss (sarcopenia) in people with COPD. The clinic brings together a team of specialists to create a treatment plan. Researchers want to see if this approach helps patients gain muscle, get stronger, …

This study is testing whether eating Medjool dates daily from 34 weeks of pregnancy helps labor start on its own, reducing the need for medical induction. Researchers will compare labor and delivery outcomes in 250 pregnant people who either eat dates or receive standard care. Th…

This study is for people who have both advanced liver disease (cirrhosis) and severe obesity. It compares two treatment paths. One group gets a two-step approach: a minimally invasive liver procedure (TIPS) followed by weight-loss surgery. The other group receives standard medica…

This study is testing whether giving methadone after major spine surgery can help patients avoid long-term dependence on opioid painkillers. Researchers will enroll 120 adults undergoing complex back surgery to see if this approach is safe and practical. The goal is to collect da…

This study is testing if a different type of heart ultrasound, done from inside the heart, can safely guide the placement of a device that helps prevent strokes in people with a common heart rhythm problem. The goal is to see if this new method works as well as the current standa…

This study is testing a computer alert system in hospital records to help doctors decide when to add a second blood pressure medication (vasopressin) for patients with severe septic shock. It will enroll 300 adults in a specific ICU to see if the system can create two groups: one…

This study is testing whether a nutritional supplement called HMB can help reverse muscle loss in people who have both alcoholic liver disease and COVID-19 pneumonia. Researchers will give the supplement to some participants and compare their muscle mass and hospital admissions o…

This study aims to see if performing a small, additional procedure during neck decompression surgery can prevent a rare complication called C5 palsy. C5 palsy causes weakness in the shoulder and upper arm, sometimes with pain, which can significantly impact recovery and quality o…

This study is testing whether using sutures coated with an antiseptic during a major pancreas surgery (called a Whipple procedure) is better than standard sutures at preventing a serious complication called a pancreatic fistula. A fistula is a leak of digestive fluid that can cau…

This study is testing a modified breathing tube designed to make anesthesia safer during surgery. It allows doctors to easily switch between two different ventilation methods without needing extra equipment. The goal is to reduce risks like low oxygen levels during procedures req…

This study is testing if a single Botox injection into the side abdominal muscles several weeks before a major hernia repair surgery makes it easier for surgeons to fully close the muscle wall. About 188 adults with very large hernias will be randomly assigned to receive either t…

This study is testing a new combination therapy to help people with severe arm and hand paralysis after a stroke. It combines a non-invasive brain stimulation technique (rTMS) with a special type of electrical muscle stimulation therapy (CCFES) to try to improve movement and func…

This study is testing whether a special nutritional supplement containing the amino acid leucine can help rebuild lost muscle in people with liver cirrhosis. Muscle loss is a common and serious problem in cirrhosis that increases the risk of complications. Researchers will compar…

This study is testing whether a quick, in-office laser procedure can help men whose enlarged prostate symptoms have returned after previous minimally invasive treatments. Researchers want to see if this approach can improve urinary flow and reduce symptoms without requiring more …

This study compares two minimally invasive surgical techniques for removing adrenal gland tumors: traditional laparoscopic surgery and newer robotic-assisted surgery. Researchers at the Cleveland Clinic will randomly assign 54 patients to one of the two procedures to see which ap…

This study is testing whether a special eye scan called optical coherence tomography (OCT) can accurately measure inflammation in the front part of the eye in people with uveitis. Researchers will scan 1,500 patients at the Cleveland Clinic who have this eye condition. The goal i…

This study aims to validate a new test to predict if a donor liver will function well after transplantation. Researchers will measure a substance called FMN in fluid samples taken from livers being prepared on a special machine. The goal is to help doctors better decide which don…

This study aims to see if a newer nerve block technique works as well as a standard one for controlling pain after major open abdominal surgery. It will involve 100 patients at the Cleveland Clinic who are randomly assigned to receive one of the two pain-blocking injections befor…

This study compares different pain relief approaches after a minimally invasive elbow tendon procedure. Researchers want to see if common anti-inflammatory drugs (NSAIDs) work as well as opioid painkillers for managing post-procedure pain. The goal is to find effective pain contr…

This study is testing whether following a gluten-free diet can improve quality of life for people with Hashimoto's thyroiditis. It focuses on participants who still experience symptoms like fatigue and brain fog even though their thyroid hormone levels are normal with medication.…

This study is testing whether an 8-week online mindfulness program can help reduce the severe fatigue often experienced by people with sarcoidosis. It will also see if the program improves symptoms of anxiety and depression. Researchers will compare the mindfulness group to a mon…

This study is testing whether doctors can comfortably use an Apple Vision Pro virtual reality headset while performing common internal exams like colonoscopies. The main goal is to see if the headset helps reduce physical strain and the risk of muscle or joint injuries for the do…

This study is testing a small, dissolvable steroid insert placed in the eye's tear duct against standard steroid eye drops. The goal is to see which method better controls pain and inflammation after surgery for certain retinal conditions. It's for adults having a specific type o…

This study aims to find the best way to prepare patients for pelvic organ prolapse surgery by comparing two counseling methods. Researchers will see if patients feel more satisfied and prepared when they attend a virtual group session with other patients or when they have a stand…

This study is testing whether women with overactive bladder are just as satisfied removing a temporary nerve stimulation lead at home as they are having it removed in a doctor's office. The lead is part of a test to see if a longer-term nerve stimulation treatment might help thei…

This study is testing a new way to manage pain after knee replacement surgery. It compares a new surgeon-administered injection inside the knee joint against two standard pain control methods. The goal is to see which approach provides better pain relief, reduces the need for ext…

This study is testing whether shockwave therapy can help men with erectile dysfunction or chronic pelvic pain. Researchers will compare two types of shockwave treatment against sham (fake) therapy to see which works better. The trial includes men with and without a history of pro…

This study compares two drugs, sugammadex and neostigmine, used to reverse muscle relaxation after anesthesia for a specific digestive procedure called ERCP. It aims to see which drug helps patients recover muscle function faster and be ready to go home sooner. The trial will als…

This study aims to understand how different settings on a deep brain stimulation (DBS) device affect sleep quality and brain activity in people with Parkinson's disease. Researchers will study 10 participants who already have a specific DBS system implanted. The goal is to gather…

This study is collecting blood and urine samples from people with different stages of alcoholic liver disease, as well as from healthy people who drink heavily and those who don't drink much. The goal is to create a large collection of samples that researchers can use to better u…

This study aims to understand why people with advanced liver scarring (cirrhosis) often lose significant muscle and fat, a condition linked to worse health outcomes. Researchers will compare small tissue samples taken during surgery from 16 cirrhosis patients and 16 healthy peopl…

This study aims to improve our understanding of uveitis, a type of eye inflammation, by looking for genetic links. Researchers will collect blood samples from 1,500 patients diagnosed with uveitis to analyze their DNA. The goal is to find specific genetic patterns that might expl…

This study aims to use detailed heart scans to better understand and predict how patients with heart failure and a leaky mitral valve will respond to different treatments. Researchers will follow 360 adults to see if specific scan results can tell doctors which patients will impr…

This study aims to use two advanced types of MRI scans to better understand and characterize muscle loss (sarcopenia) in people with heart failure. Researchers will scan 70 participants—some with heart failure and muscle loss, some with heart failure without muscle loss, and some…

This study aims to develop better MRI scans to track the progression of Autosomal Recessive Polycystic Kidney Disease (ARPKD), a serious genetic disorder. Researchers will enroll 45 ARPKD patients and 15 healthy volunteers to test new MRI techniques over several years. The goal i…

This study aims to better understand how vision changes in people with lazy eye (amblyopia) or crossed eyes (strabismus) when they receive standard treatments like glasses, eye patches, or surgery. Researchers will measure various aspects of vision, like clarity, depth perception…

This study aims to create a long-term collection of biological samples to help researchers better understand heart and blood vessel diseases. It will collect blood, urine, and stool samples from 500 adults who have or are at risk for these conditions. The goal is to build a share…

This study aims to compare different heart imaging methods to see which ones most accurately measure valve disease severity. Researchers will follow 200 adults with moderate to severe valve problems, using both standard ultrasound and advanced MRI scans. The goal is to understand…

This study aims to understand how a supplement called HA35 affects muscle protein balance in healthy people. Participants will take either HA35 or a placebo for three days, then undergo tests including a small, controlled alcohol challenge and muscle biopsies. The goal is to gath…

This study aims to understand how heart valve disease affects men and women differently using advanced heart scans. Researchers will analyze detailed heart images from 200 adults with moderate to severe valve problems to identify patterns that might explain why women often have w…

This study aims to collect blood samples from 400 healthy adults to better understand how platelets work. Researchers want to learn how these blood cells contribute to inflammation and clotting in diseases. The findings may help identify new targets for future treatments for vasc…

This study aims to understand how alcohol affects the body by comparing blood samples from three groups: healthy people, heavy drinkers without liver disease, and patients with alcoholic hepatitis. Researchers will examine how blood cells produce energy and respond to inflammatio…

This study is creating a large collection of blood, urine, stool, and tissue samples from people with and without heart or metabolic diseases. The goal is to build a library for future researchers to use, helping them understand the causes and effects of these common conditions f…

This study aims to understand why people with liver cirrhosis lose muscle mass. Researchers will use a new technique with special tracers and just one muscle biopsy to measure how muscle proteins are built up and broken down. The goal is to gather knowledge that could help develo…

This study aims to develop better tools to predict how a person's cornea will respond to surgery. Researchers will use special eye imaging and computer simulations on people with keratoconus or those scheduled for LASIK. The goal is to see if these computer models can accurately …

This study aims to understand what level of exercise is safe for people with aortic aneurysms. Researchers will use special exercise equipment inside an MRI machine to measure how the aorta responds to physical activity in 35 participants. The goal is to gather information that c…

This study is testing if a smart wristband can help monitor the heart health of pregnant women who were born with a heart condition. The goal is to see if the device can spot early warning signs of heart problems while women are at home. Researchers will enroll 50 participants to…

This study aims to understand if changing what you eat can lower levels of a specific chemical (TMAO) made by gut bacteria, which is linked to higher risk for heart problems. Researchers will enroll about 170 adults, some with high levels of this chemical. They will measure the c…

This study aims to understand how different types of exercise affect muscle loss in people with cirrhosis, a serious liver condition. Researchers will compare 12 weeks of supervised endurance cycling to supervised resistance training in 40 participants. The goal is to learn which…

This study aims to find the best combination of tests to detect a condition where small adrenal tumors produce slightly too much cortisol, a stress hormone. Researchers will follow 20 adults with these incidental tumors for four years to see if their health changes. The goal is t…

This study investigates whether GLP-1 and GIP agonist medications (used for diabetes and weight loss) affect how well patients' bowels are cleaned before a colonoscopy. Researchers will compare people who continue taking their usual dose before the procedure versus those who skip…

This study aims to see if two specific signs seen on brain scans can help doctors more accurately diagnose and track multiple sclerosis (MS) over time. Researchers will follow 40 people for four years, using detailed MRI scans to monitor these signs. The goal is to gather informa…

This study is testing a new AI-powered chatbot tool called OPUS, designed to help pregnant people make informed decisions about prenatal genetic screening tests. The tool provides personalized information and support at key points during pregnancy. Researchers want to see if usin…

This study aims to understand how alcohol consumption causes muscle breakdown in people with alcoholic liver disease. Researchers will compare 30 patients with different stages of liver disease to 10 healthy people. The main method involves taking a small sample of muscle tissue …

This study is building a collection of blood and tissue samples from people with heart rhythm disorders and healthy volunteers. Researchers aim to discover genes and biological pathways that cause these conditions by comparing samples. The goal is to improve future understanding …