The Cleveland Clinic

This study tests whether adding a hot technique to the standard cold method for removing large colon polyps lowers the chance of polyps coming back. About 194 adults with polyps 20 mm or larger will be randomly assigned to one of two procedures. All participants will have a follo…

This study follows 200 people who receive the Triathlon Hinge Knee System during knee replacement or revision surgery. Researchers will check how long the implant lasts and how well patients function at 1, 2, 6, and 10 years after surgery. The goal is to see if the device works s…

This study tests whether a leucine-enriched amino acid mixture can reverse muscle loss (sarcopenia) in people with cirrhosis, a common and serious complication. Researchers will give 32 participants either the active mixture or a placebo for 3 months, measuring muscle protein pro…

This study tests a new clinic designed to find and treat muscle loss (sarcopenia) in people with COPD. About 80 adults hospitalized for COPD will join a team of lung doctors, nurses, and a pharmacist who will use CT scans and other tests to diagnose muscle loss and provide target…

This study tests a two-step treatment for people with advanced liver disease (cirrhosis) and severe obesity. One group gets a procedure to lower liver pressure (TIPS) followed by weight-loss surgery, while the other gets standard medical care. The goal is to see if the combinatio…

This study tests whether a special mix of amino acids (HMB-enriched) can help reverse muscle loss in people with cirrhosis. About 24 participants will take either the active supplement or a placebo for 3 months. The goal is to see if the supplement boosts muscle protein productio…

This study tests a new approach for people who had a stroke at least 6 months ago and have severe arm weakness. It combines non-invasive brain stimulation (rTMS) with a therapy that uses electrical currents to help open the hand (CCFES). The goal is to see if this combination imp…

This study tests whether using a CPAP machine in a personalized way can lower the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will have their heart monitored by an implan…

This study tests whether giving the drug vasopressin earlier or later helps adults with septic shock. Researchers will use a computer tool to randomly assign 300 ICU patients to one of two timing strategies. The goal is to see if early use reduces the need for other strong blood-…

This study tests whether using antiseptic-coated sutures (stitches) during a Whipple procedure can lower the chance of a pancreatic fistula—a serious leak of digestive fluids. About 436 adults scheduled for this surgery will be randomly assigned to receive either the coated sutur…

This study tests whether the weight-loss medication tirzepatide can improve control of atrial fibrillation (an irregular heartbeat) in people with obesity. About 100 adults with a BMI of 27 or higher and symptomatic AFib will receive either tirzepatide or a placebo. The main goal…

This study tests whether doing a small bone removal (foraminotomy) at the C5 level during neck decompression surgery can prevent a rare but serious complication called C5 palsy, which causes arm weakness and pain. About 480 adults with cervical myelopathy who need posterior neck …

This study looks at whether a supplement called HMB can help reverse muscle loss in people with alcoholic liver disease who also have COVID-19 pneumonia. About 48 participants will take the supplement and be followed for 90 days to see if it improves muscle mass and reduces hospi…

This study tests a new laser treatment for men whose BPH symptoms came back after a prior minimally invasive procedure. The goal is to see if an in-office laser can improve urine flow and reduce the need for more invasive surgery. About 20 men over age 40 with moderate to severe …

This study tests whether taking a protein supplement (Ensure Enlive) in the late evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a condition causing confusion due to liver disease. About 40 adults with cirrhosis and a recent hosp…

This study tests whether a supplement called HA35 can help people with alcoholic hepatitis maintain muscle mass. About 54 participants will take either HA35 or a placebo capsule daily for 90 days. The study involves two in-person visits with tests like blood work, muscle strength…

This study aims to see if specific signs on MRI brain scans can help doctors more accurately diagnose multiple sclerosis (MS) and track how it changes over four years. Researchers will follow 40 people already in a related study, using detailed MRI scans to look for 'central vein…

This study tests whether focused or radial shockwave therapy can help men with erectile dysfunction and chronic pelvic pain, including those with a history of prostate cancer. About 186 men will receive real or sham treatments to see if symptoms improve. The goal is to find a non…

This study tests whether a one-time Botox injection into the side belly muscles, given 3-7 weeks before open surgery for a large ventral hernia, helps surgeons fully close the abdominal wall. About 188 adults will be randomly assigned to get either Botox or a placebo shot, and ne…

This study tests whether wearing a virtual reality headset (Apple Vision Pro) during colonoscopy and other scope procedures can reduce physical strain on doctors. About 140 procedures will be monitored using a standard ergonomic scoring system. The goal is to see if the headset i…

This study tests a redesigned breathing tube (supraglottic airway) that lets doctors switch between two types of ventilation without extra tools. The goal is to keep oxygen levels stable and avoid breathing complications during general anesthesia. About 100 adults having planned …

This study tests if an 8-week virtual mindfulness program (MBSR) can reduce fatigue in people with sarcoidosis. 100 participants will either join the MBSR program or a monthly virtual support group. The goal is to see which approach better improves fatigue, anxiety, and depressio…

This study compares two types of surgical tools used in a minimally invasive procedure to remove kidney stones. About 90 adults with stones between 10 and 25 mm will be randomly assigned to receive either a vacuum-assisted sheath or a standard sheath during surgery. The goal is t…

This study tests a new way to numb pain during knee replacement surgery. Doctors will inject a long-lasting anesthetic directly into the back and inner side of the knee joint. About 60 adults having knee replacement will be randomly assigned to one of three pain-blocking methods.…

This study tests a small steroid insert placed in the tear duct to control pain and inflammation after vitreoretinal eye surgery. About 30 adults having surgery for a macular hole, epiretinal membrane, or vitreomacular traction will either get the insert or standard steroid eye d…

This study tests whether a comprehensive PCOS education and lifestyle modification program delivered through virtual group sessions can improve health-related quality of life and metabolic health in women with PCOS and obesity. Forty non-pregnant women aged 18-49 with PCOS and a …

This study looks at whether giving methadone during and after major spine surgery can lower the need for long-term opioid painkillers. About 120 adults having multi-level spine fusion will be randomly assigned to receive methadone or a placebo. The main goal is to see if this app…

This study tests if using a small ultrasound probe inside the heart (ICE) is as good as the standard throat ultrasound (TEE) for placing a Watchman device. The Watchman is a device that helps prevent strokes in people with atrial fibrillation. About 100 adults who qualify for the…

This study tests a cream called ruxolitinib for skin symptoms in people with dermatomyositis, a rare autoimmune disease. The cream is applied directly to the skin. Researchers will check if it is safe and reduces skin activity after 8 and 12 weeks. The study involves 15 adults wh…

This study looks at whether women with overactive bladder can safely and comfortably remove a temporary nerve testing lead at home instead of coming back to the doctor's office. About 30 women will be randomly assigned to remove the lead themselves at home or have it removed in t…

This study tests whether virtual group counseling (Shared Medical Appointments) helps patients feel more prepared and satisfied before pelvic organ prolapse surgery, compared to standard individual phone calls. About 106 adults scheduled for surgery at Cleveland Clinic will fill …

This study compares two ways to numb the belly area before open upper abdominal surgery. One method is newer and the other is standard. The goal is to see which one works better for pain control and is easier for doctors to learn. About 100 adults having surgery like stomach or l…

This study compares two medicines, sugammadex and neostigmine, to see which one helps patients recover faster from muscle paralysis used during an ERCP procedure. About 80 adults having outpatient ERCP will be randomly assigned to receive one of the two drugs. The main goal is to…

This study tests whether eating Medjool dates from 34 weeks of pregnancy through delivery increases the chance of going into labor naturally, without needing medical help. Researchers will track 250 pregnant women at Cleveland Clinic to see if date-eaters have less need for labor…

This study compares two methods to help the stomach empty properly after the esophagus is removed (esophagectomy) for cancer or other diseases. One method uses Botox injections into the stomach valve, the other is a surgical cut (pyloromyotomy). The goal is to see if Botox works …

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. About 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available…

This study tests whether forced aerobic exercise (using a stationary bike that helps move your legs) can improve arm and leg recovery in people who had a stroke 3-9 months ago. Researchers will measure movement, brain activity, and blood markers of healing, and compare costs to s…

This study looks at how a special MRI scan can measure muscle health in people with heart failure who also have muscle loss (sarcopenia). Researchers will scan 70 adults—some with heart failure and sarcopenia, some without—to compare muscle changes. The goal is to find better way…

This study looks at how alcohol causes muscle breakdown in people with alcoholic liver disease. Researchers will take a one-time muscle biopsy to measure specific protein changes. The goal is to understand the process, not to test a treatment. About 40 adults aged 18 to 65 with a…

This study looks at how social factors like race, income, and where you live affect whether heart failure is caught early. Researchers will follow 1,000 adults at risk for heart failure to see if these factors lead to differences in diagnosis and medication use. The goal is to ma…

This study is checking if measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients and track their health for one year. The goal is …

This study looks at how the aorta behaves during exercise in people with aortic aneurysm. Researchers will use special MRI scans to measure artery flexibility and compare that to tissue samples from surgery. The goal is to help doctors and patients know what level of exercise is …

This study is for adults with a weakened heart muscle and a leaky mitral valve (functional mitral regurgitation). Researchers will use advanced MRI scans to better understand which treatments work best for each patient. The goal is to create a personalized risk score to guide the…

This study aims to learn more about uveitis, an eye inflammation condition, by looking at the genes of 1,500 patients. Researchers will collect blood samples, extract DNA, and search for genetic mutations or patterns linked to different types of uveitis. No treatment is given; th…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information so that future researchers can use them to discover what…

This study collects blood and tissue samples from 2,000 adults with or without heart rhythm problems (arrhythmias) to find genetic variants linked to these conditions. Participants include those with arrhythmias, their family members, and healthy controls. No treatment is given; …

This study looks at how 12 weeks of either resistance or endurance exercise affects muscle mass in people with cirrhosis, a liver condition that often leads to muscle loss and ammonia buildup. About 40 adults with cirrhosis will be assigned to cycling, weight training, or standar…

This study looks at people with adrenal tumors (incidentalomas) to find the most accurate tests for detecting mild autonomous cortisol secretion (MACS). Researchers will compare several tests, including blood, saliva, and urine measurements, and follow participants for 4 years to…

This study looks at how quickly muscle proteins are made and broken down in people with cirrhosis (liver scarring). Researchers will use special tracers and a single muscle biopsy to measure these processes. The goal is to better understand muscle loss in cirrhosis, not to test a…

This study looks at whether people can safely do daily bowel stimulation at home for 3 weeks before ileostomy closure surgery. The goal is to see if this routine is practical and helps the bowels work sooner, reducing hospital stays. About 34 adults who had previous colon surgery…

This study looks at whether changing what you eat can lower levels of a gut-made chemical called TMAO, which is linked to higher heart disease risk. Researchers will measure TMAO in the blood of 170 adults before and after a 12-week diet change. The goal is to see if diet alone c…

This study tests whether a special eye scan (OCT) can accurately measure inflammation inside the eye in people with uveitis, an inflammatory eye disease. Researchers will scan 1,500 patients with active or inactive uveitis to see if the scan can replace the current method of grad…

This study looks at how well people with amblyopia (lazy eye) or strabismus (crossed eyes) see, even after treatment. Researchers will measure things like sharpness, contrast, and reading ability in 150 participants. The goal is to better understand the remaining vision problems …

This study aims to see how well different heart ultrasound methods (2D and 3D echocardiography) compare to cardiac MRI for measuring heart function and valve problems. Researchers will enroll 200 adults with suspected moderate to severe heart valve disease. The goal is to improve…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with essential tremor. Researchers will use EEG and MEG to record brain activity with the stimulator on and off, and also test other tremor-reducing methods like cooling the limb or medication. …

This study aims to identify biological differences between men and women with heart valve disease (aortic regurgitation, mitral regurgitation, or aortic stenosis) using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe valve disease to develop se…

This study aims to improve how we detect and understand heart disease using advanced MRI scans. Researchers will compare new MRI techniques with standard tests in 1,000 adults, both healthy volunteers and those with various heart conditions. The goal is to find better ways to see…

This study aims to help pregnant patients make informed decisions about prenatal genetic testing. Researchers developed an AI-powered chatbot called OPUS that provides personalized information and support. The study will enroll 600 pregnant patients to see if using the chatbot in…

This study collects blood samples from 400 healthy adults aged 18 to 65 to learn how platelets work and cause inflammation and blood clots in diseases. Participants give blood at the Cleveland Clinic. No treatment or medication is given. The goal is to build a biorepository for f…

This study aims to develop imaging tools and computer simulations that predict how a person's cornea (the clear front part of the eye) will change after treatments like LASIK or corneal crosslinking. Researchers will image the eyes of 60 participants with keratoconus or those sch…

This study looks at why people with cirrhosis (scarring of the liver) often lose muscle and fat, which can make them sicker. Researchers will compare tissue samples from 16 cirrhosis patients getting a liver transplant and 16 healthy people having other abdominal surgery. They wa…

This study collects blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. The samples are stored in a biobank for future research on inflammation, metabolism, and other disease pathways. No treatments or interventions are given; the …

This study tests whether wrist-worn fitness trackers can safely and effectively monitor pregnant women with congenital heart disease at home. Researchers will track heart rhythms and other vital signs to catch early warning signs of complications. About 50 participants will wear …

This study looks at how different levels of deep brain stimulation affect sleep in people with Parkinson's disease. Ten participants will try three stimulation settings over six weeks while their sleep and brain activity are monitored. The goal is to find which setting helps them…

This study compares two common, minimally invasive surgeries to remove an adrenal gland: laparoscopic (small incisions, surgeon uses long tools) and robotic (surgeon controls a robot from a console). The goal is to see which approach leads to better patient recovery and is more e…

This study is looking for better ways to measure kidney disease progression in people with Autosomal Recessive Polycystic Kidney Disease (ARPKD), a rare genetic condition. Researchers will use special MRI scans to see if they can track changes in kidney health over three years. T…

This study looks at how a supplement called HA35 affects muscle protein in healthy adults. Twenty-four participants will take either HA35 or a placebo for three days, then complete a four-hour visit that includes blood tests, muscle biopsies, and a gut permeability test. The goal…

This study looks at how alcohol changes immune cells in the blood. Researchers will compare blood samples from 30 people: healthy controls, heavy drinkers, and patients with alcoholic hepatitis. The goal is to measure how well these cells produce energy and respond to inflammatio…

This study collects blood and urine samples from 500 people with alcoholic liver disease, heavy drinkers without liver damage, and healthy non-drinkers. The samples are stored in a biorepository so researchers can study biomarkers, immune function, and genetic factors. No treatme…

This study aims to understand if continuing GLP-1 or GIP agonist medications (used for diabetes and weight loss) affects how well patients prepare for a colonoscopy. Researchers will compare people who take their usual dose before the procedure to those who skip it, looking at bo…