The Cleveland Clinic

This study tests whether people can safely perform daily bowel stimulation at home for 3 weeks before ileostomy closure surgery. The goal is to see if this simple routine can reduce the risk of postoperative ileus (when the bowel is slow to wake up) and shorten hospital stays. Ab…

This study tests whether using antiseptic-coated sutures (stitches) during Whipple surgery can lower the chance of a pancreatic fistula—a serious leak of digestive fluids. About 436 adults scheduled for this surgery will be randomly assigned to receive either the special coated s…

This study follows 200 people who receive the Triathlon Hinge Knee system, either as a first knee replacement or to fix a previous one. Researchers will check how well the knee works and how long it lasts over 1, 2, 6, and 10 years. The goal is to see if the implant stays in plac…

This study looks at 300 adults with septic shock in the ICU. It uses a computer tool to randomly assign patients to get vasopressin either early or later, based on their norepinephrine dose. The goal is to see if the timing affects how much norepinephrine they need and if the too…

This study tests whether adding a preventive procedure (bilateral foraminotomy) during neck decompression surgery can lower the risk of C5 palsy, a rare complication that causes arm weakness and pain. About 480 adults with cervical myelopathy (spinal cord compression) will be ran…

This study tests whether using a CPAP machine in a personalized way can lower the amount of time people with sleep apnea spend in atrial fibrillation (AFib). Twenty adults with both conditions will have their heart monitored via an implanted device. Each person will alternate per…

This study tests whether a two-step procedure—first a TIPS shunt to lower liver pressure, then sleeve gastrectomy weight-loss surgery—can improve quality of life and help people with cirrhosis and severe obesity lose weight. About 70 adults aged 18-70 with both conditions will be…

This study tests whether eating Medjool dates daily from 34 weeks of pregnancy through delivery increases the chance of labor starting on its own, without needing medical induction. Researchers will track 250 pregnant women at Cleveland Clinic to see if date consumption also shor…

This study tests whether a leucine-enriched amino acid mixture can reverse muscle loss (sarcopenia) in people with cirrhosis, a common and serious complication. Researchers will give 32 participants either the active mixture or a placebo for 3 months, measuring muscle protein pro…

This study tests a new clinic designed to find and treat muscle loss (sarcopenia) in people with COPD. About 80 adults hospitalized for COPD will join a team of lung doctors, nurses, and a pharmacist who will use CT scans and other tests to diagnose muscle loss and provide target…

This study tests whether taking a protein supplement in the evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a brain condition caused by advanced liver disease. About 40 adults with cirrhosis who have been hospitalized for this co…

This study tests whether a special mix of amino acids (with HMB) can help reverse muscle loss in people with cirrhosis. Muscle loss is common in cirrhosis and can lead to serious complications. The study will involve 24 participants and will measure changes in muscle protein prod…

This study tests whether adding a hot technique to the standard cold method for removing large colon polyps lowers the chance of polyps coming back. About 194 adults with polyps 20 mm or larger will be randomly assigned to one of two procedures. All participants will have a follo…

This study tests a new approach for people who had a stroke at least 6 months ago and have severe arm weakness. It combines non-invasive brain stimulation (rTMS) with a therapy that uses electrical currents to help open the hand (CCFES). The goal is to see if this combination imp…

This study tests whether the weight-loss medication tirzepatide can improve control of atrial fibrillation (an irregular heartbeat) in people with obesity. About 100 adults with a BMI of 27 or higher and symptomatic AFib will receive either tirzepatide or a placebo. The main goal…

This study looks at whether a supplement called HMB can help reverse muscle loss in people with alcoholic liver disease who also have COVID-19 pneumonia. About 48 participants will take the supplement and be followed for 90 days to see if it improves muscle mass and reduces hospi…

This study tests a new laser treatment for men whose BPH symptoms came back after a prior minimally invasive procedure. The goal is to see if an in-office laser can improve urine flow and reduce the need for more invasive surgery. About 20 men over age 40 with moderate to severe …

This study tests whether a supplement called HA35 can help people with alcoholic hepatitis maintain muscle mass. About 54 participants will take either HA35 or a placebo capsule daily for 90 days. The study involves two in-person visits with tests like blood work, muscle strength…

This study aims to see if specific signs on MRI brain scans can help doctors more accurately diagnose multiple sclerosis (MS) and track how it changes over four years. Researchers will follow 40 people already in a related study, using detailed MRI scans to look for 'central vein…

This study tests if using a small ultrasound probe placed inside the heart (called ICE) works as well as the standard throat ultrasound for guiding the placement of a Watchman device. The Watchman is a small plug that helps prevent strokes in people with atrial fibrillation. Abou…

This study compares a small steroid insert placed in the tear duct to standard steroid eye drops for controlling pain and inflammation after vitreoretinal surgery. About 30 adults having surgery for macular hole, epiretinal membrane, or vitreomacular traction will be randomly ass…

This study tests a redesigned breathing device that lets doctors switch between two types of airway support without extra tools. The goal is to keep oxygen levels stable and reduce breathing complications during general anesthesia. About 100 adults having planned surgery will tak…

This study looks at whether women with overactive bladder can remove a temporary nerve testing lead at home instead of coming to the doctor's office. The lead is used to see if a permanent nerve device might help their symptoms. Researchers want to know if women are just as satis…

This study compares two surgical methods for removing kidney stones: one using a vacuum-assisted sheath and the other using a standard sheath. About 90 adults with kidney stones between 10 and 25 mm will take part. The goal is to see which method removes more stones and causes le…

This study is testing whether a comprehensive PCOS education and lifestyle program, delivered through online group sessions, can improve quality of life and metabolic health in women with PCOS and obesity. Researchers will compare changes in quality-of-life scores and body compos…

This study tests whether using a virtual reality headset (Apple Vision Pro) during colonoscopy and other endoscopic procedures can reduce physical strain on doctors. About 140 procedures will be performed with the headset, and researchers will measure improvements in posture and …

This study tests whether a one-time Botox injection into the side belly muscles, given 3-7 weeks before open hernia surgery, helps surgeons close the abdominal wall completely. About 188 adults with large ventral hernias will be randomly assigned to get Botox or a placebo shot. T…

This study tests a cream called ruxolitinib on skin rashes in people with dermatomyositis that haven't improved with other treatments. About 15 adults will apply the cream daily for 12 weeks. The goal is to see if the cream safely reduces rash severity and improves quality of lif…

This study tests whether focused or radial shockwave therapy can help men with erectile dysfunction or chronic pelvic pain, including those who had prostate cancer. About 186 men will receive real or sham treatments to see if symptoms improve. The goal is to find a non-drug optio…

This study tests if an 8-week virtual mindfulness program (MBSR) can reduce fatigue in people with sarcoidosis. 100 participants will either join the MBSR program or a monthly virtual support group. The goal is to see which approach better improves fatigue, anxiety, and depressio…

This study tests a new way to numb pain during knee replacement surgery. Doctors will inject a long-lasting anesthetic directly into the back and inner side of the knee joint. About 60 adults having knee replacement will be randomly assigned to one of three pain-blocking methods.…

This study looks at whether giving methadone during and after major spine surgery can lower the need for long-term opioid painkillers. About 120 adults having multi-level spine fusion will be randomly assigned to receive methadone or a placebo. The main goal is to see if this app…

This study tests whether virtual group counseling (Shared Medical Appointments) helps patients feel more prepared and satisfied before pelvic organ prolapse surgery, compared to standard individual phone calls. About 106 adults scheduled for surgery at Cleveland Clinic will fill …

This study compares two ways to numb the belly area before open upper abdominal surgery. One method is newer and the other is standard. The goal is to see which one works better for pain control and is easier for doctors to learn. About 100 adults having surgery like stomach or l…

This study compares two medicines, sugammadex and neostigmine, to see which one helps patients recover faster from muscle paralysis used during an ERCP procedure. About 80 adults having outpatient ERCP will be randomly assigned to receive one of the two drugs. The main goal is to…

This study compares two methods to help the stomach empty properly after the esophagus is removed (esophagectomy) for cancer or other diseases. One method uses Botox injections into the stomach valve, the other is a surgical cut (pyloromyotomy). The goal is to see if Botox works …

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. About 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available…

This study tests whether forced aerobic exercise (using a stationary bike that helps move your legs) can improve arm and leg recovery in people who had a stroke 3-9 months ago. Researchers will measure movement, brain activity, and blood markers of healing, and compare costs to s…

This study uses special MRI scans to see how the heart's structure and energy use change after bariatric surgery or cardiac rehab. Researchers will scan 150 adults before and 6-12 months after these treatments. The goal is to understand how these metabolic interventions affect he…

This study aims to better understand sarcopenia (muscle loss) in people with heart failure using special MRI scans. Researchers will scan 70 adults—some with heart failure and sarcopenia, some without—to measure muscle composition and energy recovery. The goal is to find imaging …

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like LASIK or corneal crosslinking. Researchers will take detailed images of the eyes of 60 participants—some with kerato…

This study looks at how the aorta works during exercise in people with aortic aneurysm. Researchers will use special MRI scans to measure artery flexibility and compare it to tissue samples from surgery. The goal is to find safe exercise levels for patients. About 35 adults, incl…

This study looks at why people with cirrhosis (scarring of the liver) often lose muscle and fat, which can make them sicker. Researchers will take small samples of muscle and fat from 16 patients with cirrhosis during liver transplant surgery and from 16 healthy people having oth…

This study looks at 20 adults with adrenal tumors to find the most accurate combination of tests for diagnosing mild autonomous cortisol secretion (MACS). Participants will provide blood, saliva, and urine samples and undergo several stimulation tests. Researchers will also follo…

This study aims to learn more about uveitis, an eye condition that causes swelling, by looking at patients' DNA. Researchers will collect blood from 1,500 people with uveitis and sequence their genes to find mutations or patterns linked to the disease. No new treatments are being…

This study tests a new AI-powered chatbot called OPUS that helps pregnant patients understand and decide about prenatal genetic testing. Researchers want to see if using the chatbot helps patients feel more informed and less conflicted about their choices. The study will involve …

This study looks at how changing the strength of deep brain stimulation affects sleep in people with Parkinson's disease. Ten participants will try three different stimulation levels over several weeks while their sleep and brain activity are monitored. The goal is to find out wh…

This study looks at how alcohol changes immune cells in the blood. Researchers will compare healthy people, heavy drinkers, and patients with alcoholic hepatitis to understand why some develop severe liver disease. The goal is to learn more about the disease, not to test a new tr…

This study is checking if measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients and track their health for one year. The goal is …

This study is for adults with a weakened heart muscle and a leaky mitral valve (functional mitral regurgitation). Researchers will use advanced MRI scans to better understand which treatments work best for each patient. The goal is to create a personalized risk score to guide the…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information so that future researchers can use them to discover what…

This study collects blood and tissue samples from 2,000 adults with or without heart rhythm problems (arrhythmias) to find genetic variants linked to these conditions. Participants include those with arrhythmias, their family members, and healthy controls. No treatment is given; …

This study looks at how 12 weeks of either resistance or endurance exercise affects muscle mass in people with cirrhosis, a liver condition that often leads to muscle loss and ammonia buildup. About 40 adults with cirrhosis will be assigned to cycling, weight training, or standar…

This study looks at how quickly muscle proteins are made and broken down in people with cirrhosis (liver scarring). Researchers will use special tracers and a single muscle biopsy to measure these processes. The goal is to better understand muscle loss in cirrhosis, not to test a…

This study looks at whether changing what you eat can lower levels of a gut-made chemical called TMAO, which is linked to higher heart disease risk. Researchers will measure TMAO in the blood of 170 adults before and after a 12-week diet change. The goal is to see if diet alone c…

This study tests whether a special eye scan (OCT) can accurately measure inflammation inside the eye in people with uveitis, an inflammatory eye disease. Researchers will scan 1,500 patients with active or inactive uveitis to see if the scan can replace the current method of grad…

This study collects blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to explore inflammation, blood clotting, gut bacteria, and other biological pathways. The goal is to create a shared resourc…

This study tests if wrist-worn fitness trackers can safely monitor pregnant women with congenital heart disease at home. Researchers will track heart rhythms and other vital signs to catch problems early. About 50 women will wear the devices and share their experiences. The goal …

This study looks at how well people with amblyopia (lazy eye) or strabismus (crossed eyes) see. Researchers will measure things like sharpness, contrast, and reading ability before, during, and after treatment. The goal is to learn more about vision problems that remain even afte…

This study looks at how alcohol causes muscle breakdown in people with alcoholic liver disease. Researchers will take a one-time muscle biopsy to measure specific protein changes. The goal is to understand the process, not to test a treatment. About 40 adults aged 18 to 65 with a…

This study looks at how social factors like race, income, and where you live affect whether heart failure is caught early. Researchers will follow 1,000 adults at risk for heart failure to see if these factors lead to differences in diagnosis and medication use. The goal is to ma…

This study aims to see how well different heart ultrasound methods (2D and 3D echocardiography) compare to cardiac MRI for measuring heart function and valve problems. Researchers will enroll 200 adults with suspected moderate to severe heart valve disease. The goal is to improve…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with essential tremor. Researchers will use EEG and MEG to record brain activity with the stimulator on and off, and also test other tremor-reducing methods like cooling the limb or medication. …

This study aims to identify biological differences between men and women with heart valve disease (aortic regurgitation, mitral regurgitation, or aortic stenosis) using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe valve disease to develop se…

This study aims to improve how we detect and understand heart disease using advanced MRI scans. Researchers will compare new MRI techniques with standard tests in 1,000 adults, both healthy volunteers and those with various heart conditions. The goal is to find better ways to see…

This study collects blood samples from 400 healthy adults aged 18 to 65 to learn how platelets work and cause inflammation and blood clots in diseases. Participants give blood at the Cleveland Clinic. No treatment or medication is given. The goal is to build a biorepository for f…

This study compares two common, minimally invasive surgeries to remove an adrenal gland: laparoscopic (small incisions, surgeon uses long tools) and robotic (surgeon controls a robot from a console). The goal is to see which approach leads to better patient recovery and is more e…

This study is looking for better ways to measure kidney disease progression in people with Autosomal Recessive Polycystic Kidney Disease (ARPKD), a rare genetic condition. Researchers will use special MRI scans to see if they can track changes in kidney health over three years. T…

This study looks at how a supplement called HA35 affects muscle protein in healthy adults. Twenty-four participants will take either HA35 or a placebo for three days, then complete a four-hour visit that includes blood tests, muscle biopsies, and a gut permeability test. The goal…

This study collects blood and urine samples from 500 people with alcoholic liver disease, heavy drinkers without liver damage, and healthy non-drinkers. The samples are stored in a biorepository so researchers can study biomarkers, immune function, and genetic factors. No treatme…

This study aims to understand if continuing GLP-1 or GIP agonist medications (used for diabetes and weight loss) affects how well patients prepare for a colonoscopy. Researchers will compare people who take their usual dose before the procedure to those who skip it, looking at bo…