Exercise explored as a tool against muscle loss in liver disease

NCT ID NCT05982769

Recruiting now Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how 12 weeks of endurance or resistance exercise affects muscle loss and ammonia buildup in people with cirrhosis. Cirrhosis can cause the liver to fail at processing ammonia, leading to muscle wasting and confusion. Researchers will compare two types of home-based exercise to standard care in 40 adults. The goal is to understand the molecular mechanisms behind exercise benefits in cirrhosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exercise (endurance training and resistance training)
What this could lead to: If successful, this could help establish specific exercise guidelines for cirrhosis patients to prevent muscle loss and improve quality of life.
What could go wrong: This is a small, early-stage study (40 participants) focused on understanding mechanisms, not proving a treatment. Results may not apply to all cirrhosis patients.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSIS, LIVER

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

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