Could a hyaluronic acid pill help alcoholic hepatitis patients keep muscle?

NCT ID NCT05018481

Recruiting now Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial at the Cleveland Clinic is testing whether a form of hyaluronic acid (HA35) can help prevent muscle loss in people with alcoholic hepatitis. 54 participants will take either HA35 or a placebo capsule daily for 90 days. The study involves two in-person visits with muscle biopsies and tests, plus phone check-ins, to see how the supplement affects muscle mass.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sodium hyaluronate (HA35)
What this could lead to: If it works, this could point toward a treatment to help maintain muscle mass in people with alcoholic hepatitis.
What could go wrong: This is a very early, small trial (54 people) testing a mechanism, not a proven treatment. It may show no benefit or have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcoholic hepatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOLIC HEPATITIS

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

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