The Cleveland Clinic

This trial tests a physician-modified stent graft to treat juxtarenal aortic aneurysms—a bulge in the aorta near the kidneys—in people who are too high-risk for open surgery. The graft is altered during the procedure to create openings that keep blood flowing to vital branch vess…

This study tests whether a Mediterranean diet with low-TMAO foods can lower levels of TMAO, a gut bacteria byproduct linked to heart disease. Researchers will compare this diet to standard heart-healthy advice in 170 adults with high TMAO. The goal is to see if diet alone can red…

This study investigates whether a wrist-worn sensor (KinesiaU) can accurately measure how long people with Parkinson's disease experience 'good on-time' — periods when medication works well and symptoms are controlled without troublesome movements. Researchers are testing IPX-203…

This study tests whether a combination of nifedipine and enalapril controls high blood pressure after childbirth better than nifedipine and labetalol. It involves 200 postpartum women with persistent hypertension. The goal is to reduce hospital stays, readmissions, and severe blo…

This study tests whether patients can safely perform a daily bowel stimulation at home for three weeks before ileostomy closure surgery. The goal is to see if this simple routine can prevent postoperative ileus (a temporary bowel paralysis) and shorten hospital stays. Thirty-four…

This study tests a modified supraglottic airway device that lets doctors switch between mask and tube ventilation without using a catheter. The goal is to improve safety during general anesthesia. About 100 adults having planned surgery will take part.

This study tests whether combining two non-invasive therapies can improve hand function in people who had a stroke at least six months ago and have severe arm weakness. The therapies are a brain stimulation technique called rTMS and a device that uses electrical stimulation to op…

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study tests whether adding a preventive procedure (bilateral foraminotomy) during standard neck decompression surgery can lower the risk of C5 palsy, a rare complication that causes arm weakness and pain. About 480 adults with cervical myelopathy (spinal cord compression) wi…

This study tests whether using antiseptic-coated sutures instead of standard ones can lower the chance of a pancreatic fistula (a leak of digestive fluid) after a Whipple procedure. About 436 adults scheduled for this surgery will be randomly assigned to receive either the coated…

This phase 2 study at the Cleveland Clinic will test whether the weight-loss drug tirzepatide (Zepbound) can help people with obesity and atrial fibrillation (AFib). About 100 participants will receive weekly injections of tirzepatide or a placebo for up to 12 months. The main go…

This study tests whether a two-step procedure can help people with advanced liver disease and severe obesity. First, a TIPS procedure lowers pressure in the liver veins. Then, sleeve gastrectomy surgery helps with weight loss. The study compares this approach to standard medical …

This study tests whether taking a protein supplement (Ensure Enlive) in the late evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a brain condition caused by liver disease. The trial enrolls 40 adults with cirrhosis who have been …

This study tests whether a special mix of amino acids with HMB can help reverse muscle loss in people with cirrhosis. Muscle loss is common in cirrhosis and can make patients weaker and increase risks before and after liver transplant. The trial will give participants either the …

This study tests whether an HMB-enriched amino acid supplement can reverse muscle loss and improve recovery in 48 patients with alcoholic liver disease and COVID-19 pneumonia. Participants receive either the HMB supplement or a balanced amino acid mix for 90 days. Researchers wil…

This study tests whether adding a hot tool to the standard cold removal of large colon polyps lowers the chance of polyps growing back. About 194 adults with flat or slightly raised polyps at least 20 mm wide will be randomly assigned to one of two procedures. Participants will h…

This early-phase trial at the Cleveland Clinic is testing whether a form of hyaluronic acid (HA35) can help prevent muscle loss in people with alcoholic hepatitis. 54 participants will take either HA35 or a placebo capsule daily for 90 days. The study involves two in-person visit…

This study tests a specialized clinic designed to diagnose and treat muscle loss (sarcopenia) in people with COPD. The clinic brings together a team of experts to provide targeted care. Researchers will see if this approach improves muscle mass and function, and reduces hospitali…

This study tests whether a leucine-enriched essential amino acid mixture can reverse muscle loss (sarcopenia) in people with liver cirrhosis. Researchers will give 32 participants either the active mixture or a placebo for 3 months, measuring muscle protein production and overall…

This study tests a cream containing ruxolitinib on the skin of 15 adults with dermatomyositis whose skin symptoms haven't improved with standard treatments. The cream is applied to affected areas for up to 12 weeks to see if it reduces redness, scaling, and other signs of disease…

This study tests a low-cost HPV test that can be done in one visit, so women get results and treatment on the same day. It aims to reduce the number of women lost to follow-up in cervical cancer screening programs. The study will enroll 1,000 women in remote areas of El Salvador.

This study follows 40 people with multiple sclerosis (MS) for 48 months to see if two MRI markers—the central vein sign and paramagnetic rim lesions—can improve how doctors diagnose and monitor the disease. Participants will have brain scans and disability tests at the end of the…

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see which measures heart valve disease more accurately. Researchers will enroll 200 adults with suspected moderate or severe valve problems. The goal is to improve how doctors assess va…

This study tests whether online group education and lifestyle coaching can improve quality of life and health markers in women with PCOS and obesity. Forty non-pregnant women aged 18-49 will be assigned to either the virtual program or usual care. Researchers will measure changes…

This study compares two surgical methods for removing kidney stones: one using a vacuum-assisted sheath and the other using a standard sheath. About 90 adults with stones between 10-25 mm will be randomly assigned to one of the two procedures. The goal is to see which method clea…

This study tests whether virtual group counseling sessions help patients feel more prepared and satisfied before pelvic organ prolapse surgery, compared to standard individual phone calls. About 106 adults scheduled for surgery at Cleveland Clinic will fill out surveys before and…

This study tests whether giving patients a personalized prediction tool and extra support for mental health and physical function can improve satisfaction one year after knee replacement surgery. About 300 adults at higher risk of dissatisfaction will be randomly assigned to eith…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in 100 adults with sarcoidosis. One group takes MBSR; the other joins a monthly virtual support group. Researchers will compare which approach …

This study looks at whether using a CPAP machine in a personalized way can reduce the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will alternate two weeks on and two week…

This study looks at whether using a virtual reality headset (like Apple Vision Pro) during endoscopy can reduce physical strain on doctors. About 140 procedures will be done with the headset, and researchers will measure posture and movement to see if it lowers injury risk. The g…

This study compares two types of nerve blocks for pain after open upper abdominal surgery. One is a newer technique (EOIFP block) and the other is a standard one (OSTAP block). The goal is to see how easy it is for doctors to learn the new block. 100 adults having surgery at Clev…

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available. The …

This study tests a tiny gel-like insert placed in the tear duct that releases dexamethasone, a steroid, to reduce pain and swelling after vitreoretinal surgery. It compares the insert to standard steroid eye drops in 30 adults undergoing surgery for conditions like macular holes …

This study tests a laser treatment for men over 40 whose enlarged prostate symptoms returned after a prior minimally invasive procedure. The treatment is done in the doctor's office and aims to improve urination and sexual function, potentially avoiding more invasive surgery. Abo…

This study looks at whether women with overactive bladder can remove a temporary nerve testing lead at home instead of coming back to the doctor's office. The lead is placed during a short procedure to see if a permanent nerve stimulator might help. Researchers want to know if wo…

This study tests whether eating Medjool dates from 34 weeks of pregnancy through delivery can increase the chance of labor starting on its own, reducing the need for medical induction. Researchers will track 250 pregnant women at Cleveland Clinic to see if date consumption affect…

This study tests if focused or radial shockwave therapy can improve erectile dysfunction and chronic pelvic pain better than a fake (sham) treatment. It includes 186 men, some with a history of prostate cancer. Participants will receive several sessions of shockwave or sham thera…

This study is testing whether changing the strength of deep brain stimulation (DBS) during sleep can help people with Parkinson's disease sleep better. Ten participants will try three different nighttime DBS settings (off, half strength, and full strength) for two weeks each. The…

This study compares sugammadex and neostigmine to reverse muscle paralysis caused by rocuronium during ERCP, a procedure to treat bile duct issues. About 80 adults will be randomly assigned to one of the two drugs. The goal is to see which drug helps patients recover faster and c…

This study tests whether giving methadone during and after major spine surgery can reduce the need for other opioids three months later. About 120 adults having multi-level spine fusion will be randomly assigned to receive methadone or a placebo. The goal is to see if this approa…

This study tests whether a one-time Botox injection into the side abdominal muscles, given 3-7 weeks before surgery, helps surgeons fully close large ventral hernias. About 188 adults will be randomly assigned to receive Botox or a placebo, and neither they nor their doctors will…

This study tests whether a heart ultrasound method called Intracardiac Echocardiography (ICE) works as well as the standard method (TEE) for placing the Watchman device in people with atrial fibrillation. The Watchman device helps prevent strokes by closing off a part of the hear…

This study tests whether forced aerobic exercise (using a bike that helps move your legs) can improve arm and leg recovery after a stroke better than traditional therapy. About 66 people who had a stroke 3-9 months ago will take part. Researchers will also check if this approach …

This pilot study tests a new pain-numbing injection called IPSA, given by the surgeon directly into the back and inner side of the knee during total knee replacement. 60 adults undergoing knee replacement will be randomly assigned to receive either the new IPSA block plus standar…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study looks at whether people with heart failure can reduce their intake of ultra-processed foods (like packaged snacks, sugary drinks, and fast food) and whether doing so improves their health. Participants will track their meals using a smartphone app and receive coaching …

This study collects data from wearable devices like Fitbit and Apple Watch to learn about daily habits and health in people with or at risk of heart failure. Researchers will combine this data with medical records to find patterns that might predict health problems. The goal is t…

This study looks at whether having a mobility technician help older patients (65+) walk up to three times a day during their hospital stay can improve their strength and recovery. Researchers will compare these patients to those receiving usual care. The goal is to see if this si…

This study looks at whether measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients at multiple hospitals. The goal is to see if FM…

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…

This study is a worldwide registry that follows 5,000 adults with breast cancer, blood cancers, or those on immune checkpoint inhibitors. Researchers collect medical records, lab results, and imaging to identify who is at risk for heart problems during or after cancer treatment. …

This study looks at how deep brain stimulation (DBS) affects brain activity in people with essential tremor. Researchers will use EEG and MEG to record brain signals with the stimulator on and off, and also test other tremor-relief methods like cooling or medication. The goal is …

This study looks at how social factors like race, income, insurance, and community distress affect whether heart failure is caught early and treated properly. Researchers will follow 1,000 adults at risk for heart failure, using blood tests and heart ultrasounds to make diagnoses…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study looks at how well people with amblyopia (lazy eye) or strabismus (crossed eyes) see before, during, and after common treatments like patching, glasses, or surgery. Researchers will measure things like sharpness, contrast, and reading ability. The goal is to better unde…

This study is testing whether a special eye scan (OCT) can accurately measure inflammation inside the eye for people with uveitis. Researchers will scan the eyes of 1500 patients and compare the results to standard exams. The goal is to find a faster, painless way to track diseas…

This study aims to uncover genetic mutations or variations linked to uveitis, an inflammatory eye disease. Researchers will collect blood samples from 1,500 patients with uveitis (including infectious types) and analyze their DNA. The goal is to better understand what causes the …

This study looks at how well the Triathlon Hinge Knee System works in people who need knee replacement surgery, either for the first time or to fix a previous one. Researchers will follow about 200 patients for up to 10 years to see how long the implant lasts and how well patient…

This study is testing a new AI-powered chatbot called OPUS to help pregnant patients make informed decisions about prenatal genetic testing. The goal is to see if the tool helps patients feel more confident and less conflicted about their choices. The study will involve 600 pregn…

This study tests whether a wrist-worn device can help monitor pregnant women with congenital heart disease. Researchers will track heart rhythms and other data from 50 participants to see if the wearable can detect early signs of trouble. The goal is to improve care and reduce th…

This study compares two standard keyhole surgeries to remove adrenal gland tumors: laparoscopic and robotic. Researchers want to see which method is faster and leads to better recovery for patients. About 54 adults with adrenal tumors will take part to help improve future care.

This study looks at 20 adults with adrenal tumors (incidentalomas) to find the most accurate tests for detecting mild autonomous cortisol secretion (MACS), a condition where the tumor releases extra cortisol. Participants will provide blood, saliva, and urine samples and undergo …

This study looks at why people with cirrhosis (scarring of the liver) often lose muscle and fat, which can make them sicker. Researchers will compare tissue samples from 16 liver transplant patients and 16 healthy people having other surgeries. They aim to measure a protein calle…

This study looks at how alcohol causes muscle breakdown in people with alcoholic liver disease. Researchers will take a small muscle sample from the thigh to measure specific proteins linked to alcohol damage. The goal is to better understand the process, not to test a treatment.…

This study uses exercise MRI to see how the aorta behaves during exercise in people with aortic aneurysm. Researchers will compare these images with tissue samples from surgery. The goal is to help doctors and patients understand safe exercise limits. The study enrolls 35 partici…

This study aims to find biological differences between men and women with heart valve disease using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe aortic or mitral valve problems. The goal is to better predict how the heart recovers after valv…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study collects blood samples from 400 healthy adults aged 18 to 65 to understand how platelets work and cause inflammation and blood clots. Participants must not have taken blood thinners in the past 10 days and must not have blood diseases. The goal is to build a blood bank…

This study looks at how GLP-1 and GIP agonists (medications used for diabetes and weight loss) affect bowel preparation quality in adults scheduled for a colonoscopy. Researchers want to see if these drugs increase the chance of poor bowel prep, and whether pausing the medication…

This study collects blood and urine samples from 500 people with alcoholic liver disease, heavy drinkers without liver disease, and healthy non-drinkers. The goal is to create a biorepository that researchers can use to study biomarkers and improve understanding of the disease. P…

This study aims to measure how fast muscles build and break down protein in people with cirrhosis (scarring of the liver). Researchers will use special tracers and a single muscle biopsy to get this information. The goal is to better understand muscle wasting, a common problem in…

This study looks at how 12 weeks of endurance or resistance exercise affects muscle loss and ammonia buildup in people with cirrhosis. Cirrhosis can cause the liver to fail at processing ammonia, leading to muscle wasting and confusion. Researchers will compare two types of home-…

This study compares immune cell function in 30 healthy volunteers, heavy drinkers, and people with alcoholic hepatitis. Researchers will analyze blood samples to measure how mitochondria (the cell's powerhouses) work and how cells respond to inflammation. The goal is to better un…

This study aims to develop better MRI-based tools to measure kidney disease progression in people with Autosomal Recessive Polycystic Kidney Disease (ARPKD), a serious genetic condition with no approved treatments. Researchers will enroll 45 ARPKD patients and 15 healthy voluntee…

This early-stage trial at the Cleveland Clinic is studying how a specific type of hyaluronic acid (HA35) affects muscle protein in 24 healthy adults. Participants take either HA35 or a placebo capsule for three days, then undergo tests including muscle biopsies and a gut permeabi…

This study is for adults with a weak heart muscle and a leaky mitral valve (functional mitral regurgitation). Researchers will use advanced MRI scans to better predict which treatments—medication or a minimally invasive valve repair—will work best for each person. The goal is to …

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…