Diet trial targets gut chemical to cut heart risk

NCT ID NCT02016430

Recruiting now Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a Mediterranean diet with low-TMAO foods can lower levels of TMAO, a gut bacteria byproduct linked to heart disease. Researchers will compare this diet to standard heart-healthy advice in 170 adults with high TMAO. The goal is to see if diet alone can reduce this risk factor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mediterranean diet with low TMAO foods
What this could lead to: If successful, this could show that a simple diet change reduces a key heart disease risk factor, offering a practical way to lower cardiovascular risk.
What could go wrong: This is an early-stage study with only 170 participants, so results may not apply to everyone. Dietary changes can be hard to stick with, and TMAO reduction may not directly prevent heart attacks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR RISK FACTOR DIETARY MODIFICATION

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

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