Diet trial targets gut chemical to cut heart risk
NCT ID NCT02016430
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether a Mediterranean diet with low-TMAO foods can lower levels of TMAO, a gut bacteria byproduct linked to heart disease. Researchers will compare this diet to standard heart-healthy advice in 170 adults with high TMAO. The goal is to see if diet alone can reduce this risk factor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mediterranean diet with low TMAO foods
What this could lead to
If successful, this could show that a simple diet change reduces a key heart disease risk factor, offering a practical way to lower cardiovascular risk.
What could go wrong
This is an early-stage study with only 170 participants, so results may not apply to everyone. Dietary changes can be hard to stick with, and TMAO reduction may not directly prevent heart attacks.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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