Can cycling unlock brain secrets in Parkinson's?

NCT ID NCT07442747

Recruiting now Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This study looks at people with advanced Parkinson's disease who already have a brain device (deep brain stimulation). Researchers want to understand how aerobic exercise—specifically cycling—changes movement, thinking, and brain activity. Thirty-six participants will do an eight-week cycling program, and the team will measure symptoms and brain signals to uncover the mechanisms behind exercise benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aerobic exercise (cycling)
What this could lead to: If it works, this could reveal how exercise improves Parkinson's symptoms, pointing toward better exercise-based therapies.
What could go wrong: This is a small, early-stage study (36 people) focused on understanding mechanisms, not testing a treatment. Results may not apply to all Parkinson's patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Motor Activity Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP BRAIN STIMULATION PARKINSON'S DISEASE

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

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