DEEP BRAIN STIMULATION

This study looks at the long-term safety of a drug called buntanetap in 500 people with Parkinson's disease. Participants include those who have taken buntanetap before and those with a deep brain stimulation device. The study lasts 36 months and tracks side effects to see if the…

This study looks at two ways to manage pain during battery replacement surgery for deep brain stimulators in people with Parkinson's disease. One method uses general anesthesia (you are fully asleep), and the other uses regional anesthesia (you are awake but numb). The goal is to…

This study tests whether a gentle, non-invasive ultrasound technique called LIFUP can increase brain activity in a memory-related area and improve memory in people with mild cognitive impairment or mild Alzheimer's. About 144 participants will receive focused ultrasound to the en…

This study looks at whether a new type of deep brain stimulation (called patterned DBS) is safe and tolerable for people with Parkinson's disease when used at home. About 60 adults who already have a DBS device will try the new stimulation pattern for two weeks. The goal is to se…

This study tests whether a new form of deep brain stimulation that adapts in real time (aDBS) works better than the standard continuous stimulation (cDBS) for people with Parkinson's disease. About 130 adults who already have a brain pacemaker implanted will be randomly assigned …

This study tests whether following a Mediterranean diet for three months after deep brain stimulation surgery helps Parkinson's patients manage weight and improve body composition. About 24 adults aged 45-64 will be randomly assigned to either receive Mediterranean diet guidance …

This study tests a new therapy called CereGate for people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. The therapy is used alongside their existing deep brain stimulation and medication. Researchers will measure c…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study looks at how different brain circuits are linked to movement and thinking in people with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will measure brain activity patterns during rest and movement, and connect them to standard …

This study involves 20 people with epilepsy who already have a deep brain stimulator implanted. Researchers will test different stimulation settings to see which ones work best to reduce seizures. The goal is to create a personalized approach to improve seizure control.

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Researchers will monitor brain activity and sleep quality in 64 adults who already have or are getting DBS implants. The goal is to understand which brain circuits are involved …

This study is creating a shared database of children who have had deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By collecting information from multiple hospitals, researchers hope to learn which children benefit most, which brain targe…

This study looks at why some people with Parkinson's disease experience thinking problems after deep brain stimulation (DBS). Researchers will scan the brains of 55 participants with DBS implants to see how stimulation changes brain networks. The goal is to help doctors choose be…

This study aims to find proteins and genetic material in the blood that can predict whether deep brain stimulation (DBS) surgery will help people with Parkinson's disease. Researchers will collect blood and leftover brain tissue from 30 participants undergoing DBS and track their…

This study looks at how the brain controls movement in children with dystonia, a condition that causes muscle spasms and twisting. Researchers will use noninvasive tests like EEG to measure brain activity at rest and during simple tasks. Some children with deep brain stimulation …

This study tests a new interface that synchronizes two types of brain stimulation—transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS)—in people with Parkinson's disease. The goal is to see if the interface can precisely time the stimulation pulses…