DEEP BRAIN STIMULATION

This study is testing the long-term safety of a daily drug called buntanetap in 500 people with Parkinson's disease over 36 months. It includes two groups: those who have taken buntanetap before and those who have a deep brain stimulation device. The main goal is to see if the dr…

This study tests a software called CereGate that fine-tunes an already-implanted deep brain stimulator to reduce freezing of gait in Parkinson's disease. About 41 participants will have their stimulator adjusted using the software. The goal is to see if this extra tuning can make…

This study tests whether a new type of deep brain stimulation (called patterned DBS) is safe and tolerable for people with Parkinson's disease to use at home. About 60 adults who already have a DBS device will try the new stimulation pattern for two weeks. The goal is to see if t…

This study tests a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can safely increase brain activity and improve memory in people with mild cognitive impairment or mild Alzheimer's disease. Participants will receive ultrasound to a k…

This study compares two ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease: adaptive DBS, which adjusts stimulation in real time based on brain signals, and continuous DBS, which delivers constant stimulation. About 130 adults who already have a DB…

This study looks at two types of anesthesia for replacing the battery of a deep brain stimulator in people with Parkinson's disease. Researchers want to see which method—general anesthesia or regional anesthesia with sedation—provides better pain control and patient satisfaction …

This study tests whether following a Mediterranean diet for three months after deep brain stimulation surgery helps Parkinson's patients control weight gain and improve body composition. Researchers will compare a diet group to a usual-diet group using weight, appetite, and quali…

This study tests whether adjusting the settings of an already-implanted deep brain stimulator can better control seizures in people with epilepsy that doesn't respond to medication. Researchers will try different combinations of stimulation strength, speed, and pulse width in 20 …

This study looks at how the brain's motor networks change over time in children with dystonia, a movement disorder. Researchers will use noninvasive tests like EEG and EMG to measure brain activity at rest and during simple tasks. Children with deep brain stimulation (DBS) will b…

This study looks at how deep brain stimulation (DBS) changes motivation and decision-making in people with Parkinson's disease. Researchers will have 70 participants play a tablet game that measures risky vs. safe choices while their brain activity is recorded. The goal is to und…

This study aims to understand how different brain circuits affect movement and thinking in people with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will measure brain activity patterns during rest and movement, and link them to motor and…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study looks at how deep brain stimulation (DBS) — a device already used to control movement in Parkinson's disease — affects sleep. Researchers will monitor brain activity and sleep quality in 64 adults with Parkinson's who have or will get DBS implants. The goal is to under…

This study is looking for clues in the blood that might tell doctors ahead of time whether deep brain stimulation (DBS) surgery will work well for a person with Parkinson's disease. Researchers will collect blood and leftover brain tissue from 30 people who are already scheduled …

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study looks at why deep brain stimulation (DBS) for Parkinson's disease can sometimes cause thinking problems. Researchers will scan the brains of 55 people with DBS implants while their device is on or off. The goal is to understand how stimulation affects brain networks, w…