PARKINSON'S DISEASE

This study is observing how well an approved Parkinson's medication works in real-world German clinics. About 125 adults with advanced Parkinson's who are prescribed Foslevodopa/Foscarbidopa will be followed for up to 12 months. Researchers will track changes in symptoms, quality…

This is a very early study testing the safety of a new one-time gene therapy called IPS101A for people with advanced Parkinson's disease. It will involve 6 participants whose symptoms are severe and not controlled by all available medications. The main goal is to find a safe dose…

This early-stage study is testing whether implanting lab-grown dopamine-producing cells into the brain is safe and can help control Parkinson's disease symptoms. It will involve about 25 patients with moderate Parkinson's who haven't responded well to standard medications. Some p…

This early-stage study is testing the safety and behavior of a new drug, LY3962681, delivered by injection into the spinal fluid. It involves healthy volunteers receiving a single dose and Parkinson's disease patients receiving two doses. The main goal is to see how well the drug…

This study aims to understand how the precise location of deep brain stimulation (DBS) in the brain affects movement difficulties in people with Parkinson's disease. Researchers are studying 24 patients who already have a DBS implant to see if adjusting the stimulation target can…

This study aims to learn more about how deep brain stimulation (DBS) surgery helps control symptoms of Parkinson's disease, essential tremor, and dystonia. Researchers will observe 200 adults with these movement disorders who are having the standard DBS surgery. During the operat…

This registry study aims to collect real-world data on how well the Vercise deep brain stimulation system helps people with Parkinson's disease. It will track about 1,500 patients worldwide to see how their symptoms and quality of life change after receiving the implanted device.…

This study is testing a new 'adaptive' brain stimulator for people with Parkinson's disease in China. The device automatically adjusts its electrical signals based on the brain's activity, aiming to provide more personalized symptom control. Researchers will compare this smart sy…

This study is testing if a non-invasive brain stimulation technique called rTMS can slow the progression of Parkinson's disease. Researchers believe improving a patient's deep, slow-wave sleep might protect the brain. The study will measure changes in movement, balance, sleep qua…

This study is testing whether a supplement called D-serine can slow the progression of Parkinson's disease. Researchers will give 100 people with early Parkinson's either D-serine or a placebo for 58 weeks to see if it improves their symptoms and protects brain cells. The goal is…

This study aims to understand why tremors sometimes return after a non-invasive ultrasound treatment for Parkinson's disease. Researchers will treat 20 people with medication-resistant tremor and follow them for two years, using brain scans and tests to find clues about who gets …

This study offers deep brain stimulation (DBS) therapy to adults with Parkinson's disease, essential tremor, or dystonia whose symptoms are not well-controlled with medication. DBS involves surgically implanting a small device that sends electrical signals to specific brain areas…

This large, late-stage study is testing whether an intravenous drug called prasinezumab can slow the worsening of movement problems in people with early Parkinson's disease. It will compare the drug to a placebo in 900 participants who are already on stable Parkinson's medication…

This is an early safety study testing a new treatment for Parkinson's disease. Doctors will inject lab-grown brain cells directly into the brains of 12 patients with moderate to advanced Parkinson's. The main goal is to see if this procedure is safe and tolerable, not to cure the…

This study is testing whether artificial intelligence (AI) can help doctors diagnose Parkinson's disease and similar conditions by analyzing videos of facial expressions and recordings of speech. Researchers will enroll 720 people, including those with Parkinson's, related disord…

This study is testing whether doctors can detect early signs of Parkinson's disease or REM sleep behavior disorder by analyzing tiny tissue samples taken during routine colonoscopies. Researchers are looking for a specific protein that builds up in people with these conditions. T…

This study is testing whether adjusting deep brain stimulation (DBS) settings can help improve vision problems in people with Parkinson's disease. Researchers will work with 40 patients who already have DBS implants to see if they can find the best stimulation settings to reduce …

This study is testing whether a non-invasive brain stimulation technique called rTMS can improve thinking skills in veterans with Parkinson's disease who have mild cognitive problems. Researchers will compare real magnetic stimulation to a sham (fake) treatment in 56 participants…

This study is testing whether a new, non-invasive brain stimulation technique can help reduce tremors and improve walking in people with Parkinson's disease. Researchers will compare the effects of real stimulation to a fake (sham) stimulation in 50 participants. The goal is to s…

This study is testing a new wearable device called an exoskeleton to see if it's safe and helpful for people with Parkinson's disease. The device straps to the legs and provides support to improve walking and balance, with the goal of reducing falls. Over eight weeks, 30 particip…

This study is testing whether physical therapy using virtual reality games and exercises works as well as or better than standard physical therapy for people with Parkinson's disease. Researchers will randomly assign 62 participants to receive either the VR-based therapy or conve…

This study is testing whether a single dose of ketamine can quickly improve depression in Veterans with Parkinson's disease. Researchers will give 80 participants either ketamine or a placebo and measure changes in mood within 24 hours. They will also check if ketamine helps the …

This study is testing if adding two mind-based therapies to standard physical rehabilitation helps people with Parkinson's disease. Participants will watch videos of movements and mentally practice them to see if it improves their balance, daily function, and quality of life. The…

This small pilot study is testing whether a smartphone app called 'Walking Tall' is practical and helpful for people with Parkinson's disease. For 6 weeks, 30 participants will use the app at home, which provides rhythmic sounds and encouraging prompts during walking sessions. Th…

This early study is testing the safety and initial effects of a new spinal cord stimulation therapy called ARC-IM. It aims to help people with Parkinson's disease who experience a dangerous drop in blood pressure when they stand up, a condition called orthostatic hypotension. The…

This study is testing whether home-based physical and mental exercises, delivered remotely via telemedicine, can help reduce chronic pain in people with Parkinson's disease. Researchers will enroll 166 Veterans with Parkinson's and chronic pain to try different combinations of th…

This study is testing whether a painless, non-invasive brain stimulation technique can help improve movement symptoms like tremors and stiffness in people with Parkinson's disease. Researchers will give 36 participants either real or placebo stimulation over two weeks and track t…

This study is testing a new communication aid called PARKINSUN, designed to help people with Parkinson's disease have better conversations with their doctors. About 120 participants will be randomly assigned to either use the tool or not during their regular check-ups over seven …

This study is testing whether adding personalized music therapy to standard physical therapy helps people with Parkinson's disease walk better and improve their balance. Researchers will compare two groups: one receiving only physical therapy and another receiving both physical t…

This study is testing a new type of exercise therapy for people with Parkinson's disease that can be done remotely. Researchers want to see if using a specially designed stationary bike, which can be monitored and adjusted by a therapist over the internet, can improve movement, b…

This study is testing whether a specific breathing and meditation program (called SKY Breath) can help reduce stress and improve quality of life for people with Parkinson's disease and their unpaid caregivers. Researchers will teach the 4-day program to 40 participants (20 patien…

This study aims to better understand brain inflammation in neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will use PET scans to measure specific inflammation markers in the brains of 184 participants, including both patients and healthy volunteers.…

This study is testing a new type of brain scan to see if it can detect clumps of a specific protein linked to Parkinson's disease, Lewy body dementia, and multiple system atrophy. Researchers will give participants a small amount of a radioactive tracer and then perform a PET/MRI…

This study aims to find a measurable sign, or biomarker, of Parkinson's disease progression. Researchers will use specialized brain scans (PET, SPECT, and MRI) on 44 participants to look at chemical and structural changes over a one-year period. The goal is to better understand t…

This study aims to understand how depression affects the brain in people with Parkinson's disease. Researchers will use PET and MRI scans to compare brain activity in four groups: people with Parkinson's and depression, Parkinson's without depression, depression alone, and health…

This study aims to understand why people with Parkinson's disease lose their balance and fall, which is a major problem with no good treatments. Researchers will have 100 Veterans with Parkinson's wear sensors at home to track their movements and will also record brain signals fr…

This study aims to better understand the brain chemistry of Parkinson's disease in its earliest stages. Researchers will use a powerful, specialized MRI scanner to measure levels of specific chemicals in the brains of people who have been recently diagnosed and are not yet on med…

This study aims to learn more about how Parkinson's disease changes over time in people who still experience movement problems like tremors and stiffness even while taking their standard medications. Researchers will observe 300 participants for up to 5 years, collecting informat…

This study aims to better understand Parkinson's disease by looking at brain chemistry and structure. Researchers will use advanced brain imaging scans (PET, SPECT, and MRI) on 42 participants aged 25-85 to identify biological markers of the disease. The findings could help guide…

This study aims to understand the connection between how people with Parkinson's disease hear and learn from speech, and how they produce their own speech. Researchers will measure speech patterns and learning abilities in 50 participants to see if challenges in understanding spe…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This early research study is testing a new imaging drug called [18F]MK-0947 that helps doctors see protein buildup in the brains of people with Parkinson's disease. The study will enroll 22 participants, including people with Parkinson's and healthy volunteers, to check if the tr…

This study aims to gather detailed information about people with movement disorders (like Parkinson's disease or tremors) and their family members. Researchers will collect medical data through exams, scans, and questions during clinic visits, but will not provide any new treatme…