PARKINSON'S DISEASE

This study looks at deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve with other treatments. DBS uses a device like a pacemaker to send electrical signals to parts of the brain that control movement, helpi…

This study tests how well a drug called Foslevodopa/Foscarbidopa helps people with early advanced Parkinson's disease. It will include 125 adults in Germany who are already prescribed this drug by their doctor. The goal is to see if it improves movement, quality of life, and dail…

This study tests an experimental drug called prasinezumab in 900 people with early-stage Parkinson's disease who are already on stable levodopa therapy. The goal is to see if the drug can delay worsening of motor symptoms compared to a placebo. Participants receive the drug or pl…

This study looks at how well the drug Foslevodopa/Foscarbidopa works for people with advanced Parkinson's disease in everyday medical practice in Belgium. About 120 adults who are already prescribed this drug by their doctor will take part and be followed for up to 18 months. The…

This early-stage study tests whether injecting special nerve cells into the brain is safe for people with advanced Parkinson's disease. The cells are made from stem cells in a lab and are meant to replace damaged brain cells that control movement. The trial involves 12 adults age…

This study provides deep brain stimulation (DBS) therapy to 300 adults with Parkinson's disease, dystonia, or essential tremor. DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement, aiming to reduce symptoms like shaking and stiff…

This early-stage study tests a new drug called LY3962681 for safety and how the body processes it. First, healthy volunteers get a single dose into their spinal fluid. Then, people with Parkinson's disease get two doses, spaced months apart. The goal is to see if the drug is safe…

This study is a registry that collects information from around the world on how well the Vercise deep brain stimulation (DBS) system works for people with Parkinson's disease. It will include up to 1,500 adults who are already eligible for this commercially available device. The …

This early study tests a spinal stimulation therapy (ARC-IM) in 5 people with Parkinson's or related conditions who experience severe drops in blood pressure when standing. The goal is to see if it is safe and can help maintain blood pressure, reducing dizziness and fainting. Par…

This early-stage study tests a new treatment called DSP-1083, which is implanted directly into the brain using a precise surgical method. The goal is to see if it is safe and if it can improve symptoms for people with Parkinson's disease. About 25 adults aged 40 to 72 with Parkin…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve deep sleep and slow the progression of Parkinson's disease. Researchers will enroll 56 adults aged 50-80 with mild to moderate Parkinson's. The approach uses magnetic pulses to enhance slo…

This study tests whether a daily dose of D-serine, a natural amino acid, can reduce symptoms and slow the progression of Parkinson's disease. One hundred people with early-stage Parkinson's will receive either D-serine or a placebo for 58 weeks. Researchers will measure changes i…

This early-stage trial tests a gene therapy called IPS101A in 6 people with advanced Parkinson's disease (stages 4-5) whose symptoms are not well-controlled by current medications. The main goal is to check safety and find the best dose, while also looking for any signs of improv…

This study looks at whether tissue samples taken from the colon during a routine colonoscopy can find signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). Researchers will check for a protein called alpha-synuclein, which is linked to Parkinson's. The goal is to cat…

This study uses artificial intelligence to analyze facial expressions and speech patterns in people with Parkinson's disease and related conditions. The goal is to create a simple, non-invasive digital tool that can help doctors diagnose and track these diseases more accurately. …

This early study tests a new imaging drug called [18F]MK-0947 that works with a PET scan to show clumps of a protein called alpha-synuclein in the brain, which are linked to Parkinson's disease. The goal is to see if the drug is safe and can help doctors better diagnose and track…

This study tests a breathing and meditation program called SKY Breath for people with early-stage Parkinson's disease (under age 75) and their care partners. Over 4 weeks, participants will learn and practice the technique daily to see if it lowers stress, anxiety, and fatigue wh…

This study compares virtual reality exercises to standard physical therapy for people with Parkinson's disease. About 62 participants aged 45-65 will be randomly assigned to one of two groups. Researchers will measure balance, mobility, and fall risk to see which approach works b…

This study tests a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) to see if it can improve thinking skills in veterans with Parkinson's disease who have mild memory or attention problems. About 56 veterans will receive the treatment, and r…

This study tests whether lemborexant, a sleep medication, can help improve both motor symptoms and sleep issues in people with Parkinson's disease. About 44 adults aged 50 and older with Parkinson's and insomnia will take the drug and be monitored for changes in movement and slee…

This pilot study tests a non-invasive device that stimulates the vagus nerve through the neck to improve walking and balance in veterans with Parkinson's disease. About 40 veterans will use the device at home while researchers measure changes in stride length and freezing of gait…

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, movement, and quality of life in people with Parkinson's disease. About 54 adults with mild to moderate Parkinson's wi…

This study tests if a smartphone app called Walking Tall can help people with Parkinson's disease improve their walking at home. Over 6 weeks, 30 participants will use the app, which provides rhythmic sounds and voice prompts to guide their steps. The goal is to see if the app is…

This study is testing whether a single intravenous dose of ketamine can quickly improve depression in 80 veterans with Parkinson's disease who haven't responded well to standard antidepressants. Researchers will also look at how ketamine affects the brain's ability to adapt and l…

This study tests an adaptive deep brain stimulation (aDBS) system that automatically adjusts stimulation based on brain signals. It enrolls 62 people with Parkinson's who already have a Medtronic Percept implant. The goal is to see if aDBS can give them at least as much good qual…

This study tests whether adding personalized music therapy to standard physical therapy improves walking and balance in people with Parkinson's disease. About 50 participants will receive either physical therapy alone or physical therapy plus rhythmic music for 8 weeks. The goal …

This study tests a non-invasive brain stimulation technique called TIS in 36 people with Parkinson's disease. Participants receive 10 sessions over two weeks, and researchers check if movement symptoms improve and if changes last up to two months. The goal is to see if this gentl…

This study tests a new way for people with Parkinson's disease to do rehab at home using a special exercise bike that doctors can monitor and adjust remotely. The goal is to improve movement and reduce symptoms without needing to travel to a clinic. About 72 veterans with mild to…

This study tests whether improving deep sleep with gentle sounds can make cognitive training more effective for people with Parkinson's disease and mild memory problems. Fifty participants will do a 5-week brain-training program at home while using a sleep device that plays soft …

This study tests whether a personalized form of transcranial magnetic stimulation (rTMS) can improve movement and non-movement symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty adults aged 30-80 will receive 10 daily se…

This study tests a non-invasive brain stimulation method called temporal interference stimulation (TIS) to see if it can reduce tremors and improve walking in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) treatment in 50 adults aged 5…

This study is testing whether a lightweight, wearable exoskeleton can help people with Parkinson's disease walk more safely and with fewer falls. Thirty veterans with mild to moderate Parkinson's will use the device during supervised walking sessions twice a week for eight weeks.…

This study looks at how the exact placement of deep brain stimulation (DBS) electrodes affects movement problems in people with Parkinson's disease. Researchers will study 24 participants who already have DBS implants to see which stimulation spots help or hinder movement. The go…

This study is testing a new tool called PARKINSUN that helps people with Parkinson's disease talk with their doctors. The goal is to make sure patients' needs are heard and addressed during checkups. About 120 adults with Parkinson's will either use the tool or not during their v…

This study is tracking 700 people with Parkinson's disease or related conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will collect information from routine doctor visits over three years, including walking tests and ques…

This study looks at how deep brain stimulation (DBS) affects eye alignment in people with Parkinson's disease. Researchers will use eye-tracking and brain models to find the best stimulation settings for improving vision while still helping with movement problems. The study invol…

This study uses a powerful 7-Tesla MRI scanner to measure brain chemicals in people newly diagnosed with Parkinson's disease who have not yet started medication, and compares them to healthy volunteers. The goal is to understand how brain metabolism changes early in the disease, …

This study looks at how people with Parkinson's disease learn to understand speech and how that relates to their own speaking ability. Researchers will measure speech clarity, speed, and pauses in 50 participants. The goal is to find links that could lead to new therapies for cle…

This study observes 300 people with Parkinson's disease who still have movement problems despite taking standard medications. Researchers will collect data on symptoms, treatments, and daily challenges over up to 5 years. The goal is to better understand how the disease changes o…

This study uses special brain scans (PET, SPECT, and MRI) to learn more about the brain changes that happen in Parkinson's disease. Researchers want to find a biological marker that could help develop new medicines to slow down the disease. The study involves 42 adults aged 25 to…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other similar diseases. Researchers want to see if inflammation levels are higher in these patients compared to healthy volunteers. Participants will have MRI…

This study aims to collect information from people with movement disorders (like tremors or Parkinson's disease) and their family members. Participants will have one visit at the NIH clinic for exams, tests, and questions. No new treatments are given, but the data will help resea…

This study follows 20 people with Parkinson's disease who have a brain procedure called focused ultrasound to stop tremors. Researchers want to understand why some people's tremors come back within two years. Participants will have brain scans and regular check-ups to find clues …

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of a protein called alpha-synuclein in the brain using PET scans. Researchers will scan 40 people, including those with Parkinson's disease, multiple system atrophy, dementia with Lewy …

This study aims to find brain changes that cause depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80 with and without depression. The goal is to identify targets for future treatments.

This study aims to find a biological marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI). Researchers will track 44 participants over time to see how certain brain cells and chemicals change as the disease progresses. The goal is to better understand…

This study follows 650 people with early Parkinson's disease or a sleep disorder called iRBD to track how the disease progresses over time. Researchers use brain scans, heart tests, and spinal fluid samples to find markers that predict changes in movement, thinking, and daily lif…

This study looks at why people with Parkinson's disease have trouble with balance and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes to understand the brain pathways involved. The goal is to gather information that could l…

This study uses a new, ultra-detailed PET scanner to see very small brain structures in healthy aging and in conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. Researchers will scan 300 volunteers and patients to find early signs of disease and create detaile…