PARKINSON'S DISEASE

This study checks the long-term safety and lasting effects of a gene therapy called IPS101A in 6 people with severe Parkinson's disease who already received it in an earlier trial. Researchers will monitor side effects and measure changes in movement symptoms over time. The goal …

This early-stage trial tests whether implanting specially grown dopamine-producing cells into the brain is safe and can help people with Parkinson's disease. Six participants receive their own lab-grown cells placed into a brain region that controls movement. The study measures c…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This study tests an adaptive deep brain stimulation (aDBS) system that automatically adjusts stimulation based on real-time brain signals. It aims to improve symptom control for 62 people with Parkinson's disease in China who already have a compatible brain implant. The main goal…

This study follows 120 adults with advanced Parkinson's disease in Belgium who are prescribed a drug called Foslevodopa/Foscarbidopa. The drug is given as a continuous infusion under the skin to help control symptoms. Researchers will track how much 'off' time (when symptoms like…

This study tests a new type of deep brain stimulation (DBS) that automatically adjusts its settings based on real-time brain signals, unlike standard DBS which uses fixed stimulation. Sixty people with Parkinson's disease will have a special neurostimulator implanted and then exp…

This registry is collecting information from 1,500 people with Parkinson's disease who are receiving deep brain stimulation (DBS) with the Vercise system. The goal is to see how DBS affects quality of life in everyday practice, and to evaluate new programming tools. Participants …

This study tests whether D-serine, a dietary supplement, can slow the progression of Parkinson's disease. One hundred people with early-stage Parkinson's will receive either D-serine or a placebo for 58 weeks. Researchers will measure changes in symptoms and brain scans to see if…

This study tests an experimental drug called prasinezumab in 900 people with early-stage Parkinson's disease who are already taking levodopa. The goal is to see if the drug can delay worsening of motor symptoms compared to a placebo. Participants receive the drug or placebo by IV…

This study is testing deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve enough with medication. DBS uses a device like a pacemaker to send electrical pulses to specific brain areas that control movement. R…

This early-stage study tests a new drug called MTX325 in healthy volunteers and people with mild to moderate Parkinson's disease. The main goals are to check safety, how the body processes the drug, and whether it reaches the brain. If successful, MTX325 might one day slow the pr…

This study tests whether a daily supplement containing a specific probiotic, tryptophan, and branched-chain amino acids can slow the progression of early-stage Parkinson's disease. Researchers will recruit 120 participants and randomly assign them to receive either the supplement…

This study looks at how well the drug combination Foslevodopa/Foscarbidopa works for people with early advanced Parkinson's disease in everyday German clinics. About 125 adults aged 18-64 who are already prescribed this drug will be followed for up to 12 months. Researchers will …

This early-stage study tests a new drug called LY3962681 in healthy volunteers and people with Parkinson's disease. The goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo injected into the spinal fluid, and are fo…

This early-stage trial tests a gene therapy called IPS101A in 6 people with advanced Parkinson's disease (stages 4-5) whose symptoms are not controlled by current medications. The main goal is to check safety and find the best dose. Researchers will also look for any signs that t…

This early-stage trial tests a cell therapy called DSP-1083, implanted directly into the brain, for people with Parkinson's disease. About 25 participants will either get the real implant or a sham surgery to see if it's safe and helps control symptoms. The goal is to replace dam…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve deep sleep and slow the progression of Parkinson's disease. Researchers will give 56 people with Parkinson's either real or sham rTMS and track changes in movement and sleep. The goal is t…

This early study tests a spinal cord stimulation therapy called ARC-IM in 5 people with Parkinson's disease or related conditions who experience severe drops in blood pressure when standing (orthostatic hypotension). The main goal is to check safety, and researchers will also mea…

This early-stage trial tests a single injection of lab-grown nerve cells into the brains of 12 people with Parkinson's disease. The cells are made from stem cells and designed to replace dopamine-producing neurons. The main goal is to check safety and tolerability over 28 days, n…

This early-phase study tests a new imaging drug called [18F]MK-0947 that works with PET scans to show where a protein called α-synuclein builds up in the brain—a hallmark of Parkinson's disease. Researchers will check safety and how well the tracer works in 22 adults (some with P…

This early-phase study tests a new radioactive tracer called [¹⁸F]MODAG-009 to see if it can safely highlight abnormal protein clumps in the brains of people with Parkinson's disease or multiple system atrophy (MSA). About 13 participants, including healthy volunteers, will recei…

This study looks at whether a protein linked to Parkinson's disease can be found in colon tissue samples taken during a routine colonoscopy. Researchers will compare samples from people with Parkinson's, those with REM sleep behavior disorder, and healthy individuals. The goal is…

This study is testing whether artificial intelligence can help diagnose Parkinson's disease by analyzing facial expressions and speech patterns. Researchers will record videos of 720 participants, including people with Parkinson's and similar conditions, as well as healthy volunt…

This study tests whether a personalized form of transcranial magnetic stimulation (TMS) can improve motor and non-motor symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty participants will receive 10 days of targeted TMS…

This pilot study tests whether an accelerated course of repetitive transcranial magnetic stimulation (rTMS) can improve movement and thinking in people with mild to moderate Parkinson's disease. Forty participants aged 50 to 90 will receive six sessions of high-frequency magnetic…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) can help with Parkinson's symptoms like walking and balance problems. Sixteen adults with Parkinson's will use the device at home for one hour daily over eight weeks. Researchers will check if it'…

This early study tests whether a spinal cord stimulation device called ARC-IM can safely improve walking and balance in people with Parkinson's disease. Six participants will receive the therapy, and researchers will monitor side effects and measure changes in gait speed and endu…

This study is testing whether a 12-week group exercise program, designed for each person's needs, is practical and helpful for people with Parkinson's disease. The program includes strength, aerobic, balance, and cognitive exercises, done both in person and at home. Researchers w…

This study compares two non-drug therapies—trunk control exercises and mirror therapy—to see which better improves balance and posture in people with Parkinson's disease. Thirty-six participants aged 50 to 70 with mild to moderate Parkinson's will be enrolled. The goal is to find…

This study tests whether mild electrical stimulation of the ear, combined with physical and speech therapy, can improve symptoms like voice problems, swallowing, and balance in people with Parkinson's disease. 46 participants will receive either active or sham stimulation during …

This study tests a new, non-invasive brain stimulation method called temporal interference stimulation (tTIS) to see if it can improve motor symptoms in people with Parkinson's disease. 90 participants will be randomly assigned to receive either real stimulation targeting specifi…

This study tests whether transcranial magnetic stimulation (TMS) timed to a person's own tremor cycle can reduce shaking in Essential Tremor and Parkinson's disease. Twenty participants with each condition will receive TMS pulses over the motor cortex while their tremor is record…

This study tests whether playing soft sounds during deep sleep can improve the effects of a home-based brain training program for people with Parkinson's disease and mild memory problems. Fifty participants will use a sleep device at night and complete cognitive exercises for fiv…

This study tests whether a non-invasive brain stimulation technique called rTMS can safely improve mild thinking problems in veterans with Parkinson's disease. Researchers will give real or fake rTMS sessions to 56 veterans and measure changes in executive function (like planning…

This pilot study tests a handheld device that gently stimulates the vagus nerve in the neck to see if it can improve walking and balance in veterans with Parkinson's disease. Forty participants will use the device at home while researchers measure changes in stride length and oth…

This study tests whether training the people who talk with someone with Parkinson's disease can make communication easier. Instead of focusing on the patient, researchers will teach their primary communication partners to better understand slurred or unclear speech. The goal is t…

This study tests whether a single dose of intravenous ketamine can quickly improve depression in veterans with Parkinson's disease. Researchers will also look at how ketamine affects brain flexibility and inflammation. The trial involves 80 veterans and compares ketamine to a mil…

This study tests a breathing and meditation program called SKY Breath in 40 people with early-stage Parkinson's and their care partners. Participants will learn the technique over four days and practice daily for four weeks. Researchers will use surveys to measure changes in stre…

This pilot study tests whether a smartphone app called Walking Tall can help people with Parkinson's disease improve their walking. Thirty participants will use the app at home for 6 weeks, doing walking exercises with audio cues and prompts. Researchers will measure step counts,…

This study looks at whether low-load or high-load resistance training works better for improving muscle strength and everyday activities in older adults with Parkinson's disease. About 60 participants with mild to moderate Parkinson's will take part. The goal is to find the most …

This study tests whether adding personalized music therapy to standard physical therapy can improve walking and balance in people with Parkinson's disease. About 50 participants will receive either physical therapy alone or physical therapy plus rhythmic music cues for 8 weeks. T…

This study tests a smart exercise bike that adjusts its resistance based on how well a person performs, aiming to improve movement and thinking in people with Parkinson's disease. The bike is used at home and monitored remotely, so patients don't need to travel to a clinic. Resea…

This study tests a tool called PARKINSUN that helps people with Parkinson's disease communicate better with their doctors during visits. 120 participants will be split into two groups: one uses PARKINSUN during appointments, the other does not. The goal is to see if the tool impr…

This study tests a walking meditation program called iWalk for adults with neurodegenerative diseases like multiple sclerosis. The goal is to see if it's feasible and helps improve resilience, stress regulation, and thinking skills. Researchers will enroll 90 participants and mea…

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life for people with Parkinson's disease. About 54 participants with mild to moderate P…

This study is testing whether a lightweight leg exoskeleton called Keeogo is safe and helpful for improving walking and preventing falls in people with Parkinson's disease. Thirty veterans with mild to advanced Parkinson's will wear the device during supervised walking sessions t…

This study tests whether a type of brain stimulation called theta-burst transcranial magnetic stimulation (TBS) can help people who experience freezing of gait—a sudden inability to start or continue walking. Forty participants will receive TBS while researchers measure how quick…

This natural history study is collecting information from up to 4,000 people with movement disorders (like Parkinson's disease or tremor) and their family members. Participants undergo exams, blood tests, and imaging, but receive no new treatments. The goal is to gather data that…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study follows 300 people with Parkinson's disease who still have movement symptoms despite taking standard medications. Researchers will collect data over up to 5 years through questionnaires, diaries, medical records, blood samples, and a digital device. The goal is to bett…

This study follows 214 people in China with multiple system atrophy, a rare and fast-worsening brain disease that affects movement and automatic body functions. Researchers will track symptoms over time to learn how the disease progresses and what factors influence it. The goal i…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Twenty participants who already have a DBS implant will spend two nights in a sleep lab—one night with the device on and one night with it off. Researchers will measure sleep qu…

This study looks at how deep brain stimulation (DBS) changes motivation and decision-making in people with Parkinson's disease. Researchers will have 70 participants play a tablet game that measures risky vs. safe choices while their brain activity is recorded. The goal is to und…

This study looks for brain scan markers that might predict thinking and memory changes after Deep Brain Stimulation (DBS) in people with Parkinson's disease. Researchers will use MRI scans before surgery and cognitive tests after surgery in 55 Parkinson's patients, plus compare t…

This study follows 650 people with early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers use brain scans, heart tests, and fluid samples to track changes over time. The goal is to better understand how these conditions de…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study aims to find the brain areas responsible for depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80 who have both conditions. The goal is to identify targets for future treatments, not to test a new therap…

This study is gathering information from 700 people with Parkinson's disease or similar conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will track symptoms, walking patterns, and falls over three years using questionnair…

This study uses a powerful 7-Tesla MRI scanner to measure brain chemicals in people newly diagnosed with Parkinson's disease who have not yet started medication, and compares them to healthy volunteers. The goal is to better understand how brain metabolism changes early in the di…

This study looks at how people with Parkinson's disease learn to understand speech and how that relates to their own speaking ability. Researchers will have 50 participants with Parkinson's do listening and speaking tasks to measure speech perception and production. The goal is t…

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This study looks at how the exact placement of deep brain stimulation (DBS) electrodes in the brain affects movement problems in people with Parkinson's disease. Researchers will study 24 participants who already have DBS implants to see which stimulation locations improve sympto…

This study follows 20 people with Parkinson's disease who receive a brain treatment called focused ultrasound to stop tremors. Researchers want to understand why some patients' tremors return within two years. Participants will have brain scans and regular check-ups to find clues…

This study looks at how deep brain stimulation (DBS) affects the ability to align and focus both eyes on objects at different depths in people with Parkinson's disease. Researchers will use eye-tracking and brain models to find the best stimulation settings. The goal is to improv…

This early-phase study tests a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. Researchers will scan 40 volunteers, including healthy people and those with Parkinson's disease, multiple system atrophy…

This study aims to understand why people with Parkinson's disease have balance problems and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes in 100 Veterans. The goal is to find brain pathways linked to balance issues so new…

This study uses special brain scans (PET, SPECT, and MRI) to look for a marker that shows how Parkinson's disease changes over time. Researchers will scan 44 people with Parkinson's to see if a compound called BU99008 can highlight brain cell activity linked to the disease. The g…

This study uses advanced brain scans (PET and MRI) to examine serotonin activity in people with Parkinson's disease. Researchers will compare brain images from 42 participants at different stages of the disease. The goal is to find biological markers that could lead to new treatm…