PARKINSON'S DISEASE

This study aims to find better ways to catch early signs of memory loss in community settings and test if new treatments can slow it down. It will involve 600 adults aged 55 and older in the U.S. who have mild cognitive impairment. Researchers will compare standard care against w…

This study aims to gather real-world information on how well an already-approved Parkinson's disease treatment works and how safe it is for patients in their regular care. About 100 adults with advanced Parkinson's who are newly prescribed this medication by their doctor will be …

This study is testing a new, non-invasive brain stimulation technique called Temporal Interference Stimulation (TIS) to see if it can help improve movement symptoms in people with Parkinson's disease. Researchers will enroll 24 adults with mild to moderate Parkinson's to receive …

This study aims to check the long-term safety and effects of an experimental injection called RGL-193 in people with Parkinson's disease. It will follow 6 patients who have already received the injection in a previous study for 5 years. The main goal is to see if the treatment re…

This study is testing whether improving deep sleep with gentle sounds can make brain training more effective for people with Parkinson's disease who have mild memory problems. Fifty participants will do a 5-week brain fitness program at home and wear a special headband at night; …

This study will follow 120 adults in Belgium with advanced Parkinson's disease who are already prescribed a specific medication (Foslevodopa/Foscarbidopa). The goal is to see how well the treatment controls their symptoms in real-life clinic settings, not in a controlled experime…

This study is testing if using objective data from brain scans and recorded brain signals can help doctors program deep brain stimulation (DBS) devices more effectively for people with Parkinson's disease. Researchers will compare this data-guided method to the standard, more sub…

This study is testing if terazosin, an existing blood pressure drug, can slow the progression of Parkinson's disease by boosting energy levels in brain cells. It will involve 100 people with early-stage Parkinson's who will take either terazosin or a placebo for 6 months. Researc…

This study is testing a breathing exercise program to help people with Parkinson's disease who have a forward-leaning posture. The training aims to strengthen breathing muscles to improve cough strength, swallowing safety, and reduce drooling. Researchers want to see if this non-…

This study is testing whether adding a special wedge under the front of the foot during balance training can help people with Parkinson's disease walk more steadily. Thirty participants with moderate Parkinson's will do physical therapy, with half also using the wedge and a speci…

This study aims to see if fine-tuning deep brain stimulation (DBS) settings can help improve specific vision problems common in Parkinson's disease, like double vision and difficulty focusing at different depths. Researchers will study 80 people who already have DBS implants, usi…

This study is testing whether wearing special gloves and socks containing menthol can help improve movement and sleep for people with Parkinson's disease. It will involve 80 participants who will use either the menthol items or a placebo version for four weeks. The goal is to see…

This study is testing whether a prescription sleep medication called lemborexant can help improve both movement problems and poor sleep in people with Parkinson's disease. About 44 participants with Parkinson's and insomnia will take the drug or a placebo nightly for 28 days. Res…

This VA study is testing if a simple, at-home device that gently stimulates a nerve in the neck can improve walking and balance for Veterans with Parkinson's disease. The goal is to reduce falls and help people stay independent longer. About 40 participants will use the handheld …

This study aims to understand how different types of aerobic exercise, like forced or voluntary cycling, affect the brain and improve movement and thinking in people with advanced Parkinson's disease who already have a deep brain stimulation device. Researchers will measure brain…

This study aims to better understand freezing of gait, a sudden inability to walk that affects people with Parkinson's disease and similar conditions. Researchers will observe 700 patients over three years, collecting information on their symptoms, walking patterns, and falls dur…