PARKINSON S DISEASE

This early-stage study is testing the safety of a one-time gene therapy for Parkinson's disease. The therapy aims to deliver a protective protein (GDNF) directly into a specific brain region to support the cells affected by the disease. The study involves 11 participants with Par…

This early-stage study is testing the safety of a new approach for Parkinson's disease. During a standard deep brain stimulation (DBS) surgery, doctors also implant a small piece of the patient's own nerve tissue into specific brain areas. The goal is to see if this implanted tis…

This study is testing whether a special rehabilitation program that combines brain training exercises with walking and balance practice can help people with Parkinson's disease. The program aims to improve both movement problems like walking stability and thinking skills like mem…

This study follows people with Parkinson's disease or a related condition who previously received an experimental gene therapy called AB-1005. Researchers want to understand the long-term safety of the treatment and see how well its effects last over time. The study is observatio…

This study is testing if a specific type of partnered dance exercise is better than regular walking for people with Parkinson's disease. Researchers want to see if dance can reduce troublesome 'off-times' when medications wear off, improve memory and thinking, and potentially pro…

This study is testing whether an investigational drug called BIA 28-6156 can slow the worsening of movement problems in people with Parkinson's disease who have a specific genetic change in the GBA1 gene. About 237 participants will take either the drug at one of two doses or a p…

This study is testing whether an intravenous drug called prasinezumab can slow the progression of Parkinson's disease in people who are in the early stages. Over 300 participants will receive either the drug or a placebo for one year, with the option to continue treatment for up …

This study is testing whether very low doses of radiation, guided by special brain scans, can slow the progression of Parkinson's disease. Researchers will give five radiation treatments to 20 participants with early-stage Parkinson's and measure changes in their movement symptom…

This early-stage study is testing the safety and feasibility of a new approach for Parkinson's disease. During a standard deep brain stimulation surgery, doctors will also implant a small piece of the patient's own leg nerve into a specific area of the brain. The goal is to see i…

This study is testing whether daily exposure to bright light can help improve sleep quality and reduce daytime sleepiness in people with Parkinson's disease. Researchers will measure sleep patterns, alertness, and body clock signals in 65 participants. The goal is to see if this …

This study aims to improve the tests used to diagnose chronic autonomic failure, a condition where the body's automatic functions like blood pressure control stop working properly. Researchers will enroll about 89 adults with conditions like Parkinson's disease, multiple system a…

This study aims to better understand how early Parkinson's disease and a related condition called multiple system atrophy progress over time. Researchers will follow 150 participants for 18 months, tracking their symptoms, movement abilities, and quality of life. The goal is to g…

This study aims to translate a Parkinson's disease cognitive assessment scale into Turkish and check if it works reliably. Researchers will test the translated scale on 60 Turkish patients with Parkinson's disease to see if it accurately measures their thinking and memory problem…

This study follows Parkinson's disease patients with and without a specific gene mutation (GBA) to see how quickly their brain networks change over time. Researchers use brain scans (PET and MRI) to measure these changes, hypothesizing that patients with the GBA mutation experien…