PARKINSON'S DISEASE

This study tests a new gene therapy called VGN-R09b in 39 people with Parkinson's disease. The goal is to see if it is safe and can help control motor symptoms like tremors and stiffness. Participants must have at least 2.5 hours of 'off' time per day despite standard treatment. …

This early-stage study tests whether a gene therapy called AAV2-GDNF is safe for people with Parkinson's disease. The treatment delivers a protein that helps protect brain cells involved in movement. Eleven adults with mild to severe Parkinson's will receive the therapy and be mo…

This study tests an experimental drug called prasinezumab in people with early Parkinson's disease. The drug is designed to target and remove clumps of a protein thought to play a role in Parkinson's. 316 participants will receive either the drug or a placebo for 52 weeks, with a…

This study is for people with Parkinson's disease who are already scheduled for deep brain stimulation (DBS) surgery. During the surgery, doctors will also implant a small piece of the patient's own nerve tissue into specific brain areas. The goal is to see if this added step is …

This early-stage trial tests whether implanting a small piece of a patient's own leg nerve into a key brain area during deep brain stimulation (DBS) surgery is safe and feasible. Ten people with Parkinson's disease will receive the implant and be followed for at least a year. The…

This study tests whether ultra-low doses of radiation, guided by special brain scans, can slow the worsening of motor symptoms in Parkinson's disease. Twenty adults aged 45 to 70 with early-stage Parkinson's will receive five daily radiation treatments. The goal is to see if this…

This study tests an experimental drug (BIA 28-6156) in 237 people with Parkinson's disease who have a specific change in the GBA1 gene. The goal is to see if the drug can delay worsening of motor symptoms over 78 weeks compared to a placebo. Participants are randomly assigned to …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help reduce depressive symptoms in people with Parkinson's disease. About 50 participants will be randomly assigned to receive either real rTMS or a …

This study tests whether doing physical and mental exercises at home, guided by remote technology, can reduce chronic pain in people with Parkinson's disease. 166 Veterans with Parkinson's will take part. The goal is to find a simple, affordable way to manage pain that patients c…

This study tests a non-invasive device that delivers gentle vibrations to the skin to help improve movement in people with moderate Parkinson's disease. The treatment aims to disrupt abnormal brain signals that cause stiffness and slowness. Thirty adults aged 45 to 90 with modera…

This study looks at whether bright light exposure can help people with Parkinson's disease sleep better and feel more alert during the day. Researchers will measure sleep quality, daytime sleepiness, and other non-motor symptoms in 65 participants. The goal is to find a simple, d…

This study looks at whether partnered dance aerobic exercise can improve movement and thinking in people with Parkinson's disease. About 82 participants will take part in dance sessions or other activities. The goal is to see if dancing can reduce "OFF-time" when medications don'…

This study tests whether a year-long mindfulness-based therapy can reduce stress, anxiety, and depression in 174 people with Parkinson's disease. Participants are randomly assigned to either the mindfulness program or their usual care. The goal is to see if lowering stress improv…

This study looks at whether adding specific cognitive (thinking) exercises to balance and walking training can improve balance, walking, and mental function in people with Parkinson's disease. Fourteen participants with mild to moderate Parkinson's will undergo 12 training sessio…

This study uses a special brain scan called PIB PET to look at different types of dementia in people with Parkinson's disease. The goal is to find out who might develop dementia and what causes it. Researchers will study 320 participants to better understand these brain changes.

This study translates a scale that measures how thinking problems affect daily life in people with Parkinson's disease into Turkish and checks if it is accurate and reliable. About 60 people with mild to moderate Parkinson's will take part. The goal is to give doctors a better to…

This study follows 32 people with Parkinson's disease to see if those with a specific gene change (GBA mutation) have faster changes in brain activity over time. Participants will have brain scans and tests of movement and thinking. The goal is to understand how genes influence t…

This study aims to improve how doctors test for chronic autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. It includes people with Parkinson's disease, multiple system atrophy, or related issues. Participants under…

This study follows 150 people with early Parkinson's disease or Multiple System Atrophy (MSA) for up to 18 months. Researchers measure changes in movement, daily living, and quality of life to better understand how these conditions progress. The goal is to gather detailed informa…

This study follows 132 people with Parkinson's disease or multiple system atrophy who previously received AB-1005 gene therapy. Researchers will track safety and how well the treatment works over time. Participants are simply observed, with no new treatments given.