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Zapping the brain without surgery: a new hope for Parkinson's?

NCT ID NCT07698236

Disease control Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study tests a noninvasive technique called temporal interference stimulation (TIS) to see if it can improve motor symptoms in people with Parkinson's disease and related conditions. Participants receive both active and sham stimulation in a random order, with each session lasting 30 minutes over three days. The main goal is to measure changes in movement scores using a standard rating scale. If successful, TIS could offer a safer alternative to implanted deep brain stimulators.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Temporal Interference Stimulation (TIS) device
What this could lead to
If effective, this could offer a noninvasive way to improve motor symptoms in Parkinson's disease, potentially reducing the need for invasive deep brain stimulation surgery.
What could go wrong
This is an early-stage crossover study with only 100 participants. The effects may be modest or not last, and individual responses can vary. Risks include discomfort from stimulation and the possibility that sham stimulation may also show some benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 40 to 80 years, diagnosed with idiopathic Parkinson's disease or Parkinsonian syndromes according to the Movement Disorder Society (MDS) diagnostic criteria. 2. Receiving stable doses of levodopa or other dopaminergic medications for at least 4 weeks prior to enrollment, with a documented response to levodopa; medication regimen must remain unchanged during the study. 3. Hoehn and Yahr (H\&Y) stage ≤ 3 in the "ON" medication state. 4. Normal cognitive function, defined as a Mini-Mental State Examination (MMSE) score ≥ 24. 5. Able to maintain and cooperate with Parkinson's disease symptom diaries. 6. Signed written informed consent. Exclusion Criteria: 1. Presence of other neurological or psychiatric disorders that may interfere with study participation or outcomes. 2. Previous treatment with deep brain stimulation (DBS) or other invasive brain stimulation therapies. 3. Orthopedic or other medical conditions that could affect gait or balance. 4. Contraindications to MRI, such as claustrophobia or other factors making MRI unsuitable. 5. History of taking antipsychotic, antidepressant, or other medications that may affect dopamine levels. 6. Contraindications to electrical stimulation, such as implanted cardiac pacemakers or a history of epilepsy. 7. History of electroconvulsive therapy (ECT). 8. Severe comorbidities, including cardiovascular disease, respiratory disease, or hepatic/renal dysfunction.

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Conditions

The condition(s) this trial relates to.

Parkinson disease parkinsonian disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease Parkinsonian syndromes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital

    Shanghai, China

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