Zapping the brain without surgery: a new hope for Parkinson's?
NCT ID NCT07698236
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study tests a noninvasive technique called temporal interference stimulation (TIS) to see if it can improve motor symptoms in people with Parkinson's disease and related conditions. Participants receive both active and sham stimulation in a random order, with each session lasting 30 minutes over three days. The main goal is to measure changes in movement scores using a standard rating scale. If successful, TIS could offer a safer alternative to implanted deep brain stimulators.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Temporal Interference Stimulation (TIS) device
- What this could lead to
- If effective, this could offer a noninvasive way to improve motor symptoms in Parkinson's disease, potentially reducing the need for invasive deep brain stimulation surgery.
- What could go wrong
- This is an early-stage crossover study with only 100 participants. The effects may be modest or not last, and individual responses can vary. Risks include discomfort from stimulation and the possibility that sham stimulation may also show some benefit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital
Shanghai, China
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