Could an antibody slow Parkinson's? new trial hopes to find out

NCT ID NCT03100149

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests an experimental drug called prasinezumab in 316 people with early Parkinson's disease. The drug is an antibody designed to target and remove clumps of a protein linked to Parkinson's. Participants receive either the drug or a placebo for 52 weeks, with an option to continue treatment for up to 11 more years. The goal is to see if the drug can slow the worsening of symptoms.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON'S DISEASE

Contacts and locations

Locations

Associated Neurologists of Southern CT PC

Fairfield, Connecticut, 06824, United States
Aventura Neurologic Associates

Aventura, Florida, 33180, United States
Barrow Neurology Clinics

Phoenix, Arizona, 85013, United States
Baylor College

Houston, Texas, 77030, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
CHU Poitiers

Poitiers, 86021, France
CHU Rouen Charles Nicolle

Rouen, 76031, France
CHU de Nantes - Hopital Laennec

Saint-Herblain, 44800, France
CHU de Nice Hopital Pasteur

Nice, 06002, France
CIC - Hôpital Purpan

Toulouse, 31059, France
CenExel Rocky Mountain Clinical Research, LLC

Englewood, Colorado, 80113, United States
Central Texas Neurology Consultants

Round Rock, Texas, 78681, United States
Clinica Universidad de Navarra

Pamplona/iruña, Navarre, 31008, Spain
Columbia University

New York, New York, 10032, United States
Corewell Health Neurology and Epilepsy - Beltline

Grand Rapids, Michigan, 49525, United States
DZNE Clinical Trial Unit

München, 81377, Germany
Fundacion Hospital de Alcorcon

Alcorcón, Madrid, 28922, Spain
Groupe Hospitalier Pellegrin

Bordeaux, 33000, France
Heinrich-Heine Universitätsklinik Düsseldorf

Düsseldorf, 40225, Germany
Henry Ford Health System

West Bloomfield, Michigan, 48322, United States
Hopital Gabriel Montpied

Clermont-Ferrand, 63003, France
Hopital Henri Mondor

Créteil, 94010, France
Hopital Pitie-Salpetriere APHP

Paris, 75013, France
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hospital General de Catalunya

Sant Cugat del Vallès, Barcelona, 08195, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Virgen Macarena

Seville, 41009, Spain
Hospital Universitario de la Princesa

Madrid, 28006, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, 08025, Spain
Hôpital Michallon - Centre d'Investigation Clinique

Grenoble, 38043, France
Klinik fur Neurologie

Berlin, 10117, Germany
Klinik und Poliklinik für Neurologie Universitätsklinikum

Leipzig, 04103, Germany
Medizinische Universität Innsbruck

Innsbruck, 6020, Austria
Molecular Neurolmaging

New Haven, Connecticut, 06510, United States
Neurology Center of North Orange County

Fullerton, California, 92835, United States
Northwestern University

Evanston, Illinois, 60208, United States
Oregon Health & Science Uni

Portland, Oregon, 97239, United States
Paracelsus Elena Klinik Kassel

Kassel, 34128, Germany
Parkinson's Disease and Movement Disorders Center of Boca Raton

Boca Raton, Florida, 33486, United States
Philipps Universität Marburg

Marburg, 35043, Germany
Policlínica Guipuzcoa

Donostia / San Sebastian, Guipuzcoa, 20014, Spain
Quest Research Institute

Farmington Hills, Michigan, 48334, United States
The Movement Disorder Clinic of Oklahoma

Tulsa, Oklahoma, 74136, United States
UNIVERSITY of PENNSYLVANIA

Philadelphia, Pennsylvania, 19107, United States
USC Keck Medical Center of USC

Los Angeles, California, 90033, United States
USF Parkinsons Disease and Movement Disorders Center

Tampa, Florida, 33613, United States
Uab Medicine

Birmingham, Alabama, 35233, United States
Universitaettsklinikum Tübingen

Tübingen, 72076, Germany
University of California at San Francisco

San Francisco, California, 94115, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Rochester Medical Center

Rochester, New York, 14618, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
Universitätsklinikum Ulm

Ulm, 89081, Germany
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
hopital de la Timone

Marseille, 13385, France

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