PARKINSON'S DISEASE

This early-stage study tested a gene therapy that delivers a protective protein called GDNF directly to the brain in 25 people with advanced Parkinson's disease. The goal was to see if it is safe and if it might help protect dopamine-producing brain cells. Participants received t…

This early-stage study tested a new drug called BIIB094 in 62 adults with Parkinson's disease. The drug was given as an injection into the spinal fluid to see if it is safe and how the body processes it. The main goal was to check for side effects, not to treat the disease. This …

This study looked at whether long-term aerobic exercise can slow the progression of Parkinson's disease. 57 people with mild to moderate Parkinson's took part. They exercised regularly and researchers measured changes in movement, thinking, and driving safety. The goal was to see…

This study tested a new gene therapy for Parkinson's disease. It involved 14 people and aimed to see if delivering a gene to a specific brain area is safe. The therapy uses a harmless virus to carry the gene. This is an early-stage trial focused on safety, not yet on effectivenes…

This early study tested a gene therapy called BBM-P002 in 10 people with advanced Parkinson's disease. The main goal was to see if the treatment is safe and tolerable. Researchers also looked at whether it could improve symptoms or reduce the need for daily Parkinson's medication…

This early-phase study tested whether low-dose lithium aspartate (30-45 mg/day) could slow Parkinson's disease in 15 people diagnosed within the last 4 years. Researchers measured changes in brain scans and blood markers linked to disease progression. The goal was to see if lithi…

This study tested whether exenatide, a drug already used for diabetes, can slow the progression of Parkinson's disease. 194 people with early-stage Parkinson's received either exenatide or a placebo for 2 years. The goal was to see if the drug could protect nerve cells and reduce…

This study tested a new deep brain stimulation (DBS) system that uses directional leads to more precisely target brain areas involved in Parkinson's disease. The goal was to see if this system could effectively improve motor symptoms while reducing side effects. Twenty-six adults…

This study tested a new treatment made from stem cells for people with Parkinson's disease. The goal was to see if it is safe and if it can slow down or reverse brain damage. Twelve patients who had Parkinson's for at least 5 years received a single injection of these cells into …

This study tested whether a brain scan (fMRI) can detect early signs of Parkinson's disease by measuring how a small brain area called the superior colliculus responds to light. Researchers compared newly diagnosed Parkinson's patients (not yet on medication) with healthy volunte…

This small study tested whether combining aerobic exercise with virtual reality can improve walking, balance, and thinking in people with Parkinson's disease. Ten participants completed the program, and researchers measured changes in movement, cognition, and brain activity. The …

This small study tested a digital therapy called DART that uses augmented reality to help people with Parkinson's disease who have a brain stimulator improve their walking and balance. Seven adults completed the program, and researchers measured changes in movement and walking di…

This small study tested the safety of using focused ultrasound to create a tiny lesion in the brain area that controls movement, aiming to ease Parkinson's motor symptoms. Seven adults with advanced Parkinson's took part. The main goal was to check for side effects and see if mov…

This early-stage study tested a new drug called UCB0022 in 100 people, including healthy volunteers and those with Parkinson's disease. The main goal was to see if the drug is safe and how the body processes it. Researchers gave single and multiple doses to find the right amount …

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers measured changes in depression scores and also used brain s…

This study tested three different non-invasive treatments to help people who have trouble swallowing after a stroke or due to Parkinson's disease. The treatments included a gentle brain stimulation technique called tDCS and a muscle stimulation therapy. The goal was to see if the…

This study looked at whether a mindfulness program (MBSR) can improve quality of life, thinking, and mood in people with Parkinson's disease. 107 adults with Parkinson's took part. The goal was to see if learning to be present and calm could help manage daily challenges.

This study tested a brain stimulation technique to improve walking and balance in people with advanced Parkinson's disease. Six participants received deep brain stimulation in a brain area that controls movement. The goal was to see if this could reduce falls and freezing of gait…

This study tested a non-invasive treatment called TENS (transcutaneous electrical nerve stimulation) for bladder issues in people with Parkinson's disease or a related condition called multisystem atrophy. The treatment involves placing a small electrical patch near the ankle for…

This study tested whether a combined speech and exercise program delivered remotely could improve speech clarity in people with Parkinson's disease. Nearly 90% of people with Parkinson's have speech problems that make communication difficult. The study involved 104 veterans and u…

This study tested whether methylphenidate (Ritalin), a drug used for ADHD, could improve walking problems and attention in people with advanced Parkinson's disease. 69 participants with severe gait issues and freezing episodes were given either the drug or a placebo for 3 months.…

This study tested whether a non-invasive technique called repetitive transcranial magnetic stimulation (rTMS) can safely reduce musculoskeletal pain in people with Parkinson's disease. Researchers treated 62 participants with rTMS or a sham procedure and measured pain changes usi…

This study tested whether stimulating the front part of the brain could help with mood and behavior problems in people with Parkinson's disease. Five participants received temporary brain stimulation at home, alternating between real and sham (fake) stimulation. The results sugge…

This study tested a new tablet called CVN424 in 64 people with early Parkinson's disease who were not yet on other treatments. Half received the drug and half received a placebo for 12 weeks. The goal was to see if CVN424 could improve movement and daily living skills compared to…

This small study tested whether spinal cord stimulation can improve walking in people with Parkinson's disease whose symptoms are not well controlled by medication. Five participants received a spinal cord stimulator, and researchers measured changes in walking ability and freezi…

This study tested whether clonidine, a drug used for high blood pressure, can help reduce impulse control disorders (like gambling or overeating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The goal was to see if clonidi…

This study looked at abnormal brain wave patterns in 23 people with Parkinson's disease to understand how these signals travel between different brain areas. The goal was to learn more about the disease itself, not to test a new treatment. Findings may help guide future therapies…

This study looked at the DNA of over 2,500 people, including those with Parkinson's disease and healthy volunteers, to find genetic mutations linked to the condition. Researchers focused on several genes, including parkin, to better understand why Parkinson's develops. The goal w…

This study looked at how the brain controls movement in adults with conditions like Parkinson's disease, Tourette's syndrome, and dystonia, compared to healthy volunteers. It used brain scans and other tests to gather information, but did not provide any treatment. The goal was t…

This study looked at brain signals in 21 people with essential tremor or Parkinson's disease during deep brain stimulation (DBS) surgery. Researchers placed temporary recording strips on the brain's surface to measure electrical activity. The goal was to better understand how tre…

This study looked at 70 people with Parkinson's disease to see if following the DASH diet (a heart-healthy eating plan) was linked to better heart health markers. Researchers measured things like blood fats, blood sugar, and inflammation. The goal was to understand the connection…

This study used blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers to see how the drug deferiprone affects cell stress and energy. The goal was to learn more about the disease process, not to treat patients. Results may guide future research.

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how dopamine problems affect these conditions. No treatment was given; it was pur…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects from pesticides and farm work. Researchers confirm self-reported diseases like asthma and Parkinson's by reviewing medical records and collecting cheek swabs. The goal is to understand ho…

This study looked at 700 people with Parkinson's disease to find clues that predict whether deep brain stimulation will improve their quality of life. Researchers checked factors like brain scans, genetics, and health records before treatment and then followed patients for up to …

This study looked at how two brain chemicals, dopamine and serotonin, change over time in people with Parkinson's disease. Researchers used special PET scans to compare early, middle, and late-stage patients, as well as healthy volunteers. The goal was to better understand non-mo…

This study looked at how people with Parkinson's disease perceive the world around them, including vision and unusual experiences like seeing things that aren't there. Researchers surveyed 54 adults with Parkinson's online to see how these perceptions relate to mood, sleep, and t…

This study aimed to find genetic causes of Parkinson's disease by observing over 20,000 participants diagnosed within the last 5 years. Researchers focused on identifying people with a specific gene change (LRRK2) and developing a biomarker for that group. The study did not test …

This study looked at how people with Parkinson's disease explain good and bad events in their lives, and whether deep brain stimulation (DBS) changes that. Researchers measured thinking biases in 32 patients using a questionnaire. The goal was to understand if DBS affects social …

This study looked at whether balance and walking problems in Parkinson's disease are caused by inner ear issues, not just low dopamine. Researchers tested 60 people with Parkinson's using standard inner ear exams and brain scans. The goal was to better understand why these proble…

This study looked at whether a special video game (serious game) could be a practical and liked way to help 10 Parkinson's patients improve their walking and balance. All participants had already had brain surgery for their condition. The main goal was to see if patients would us…