PARKINSON S DISEASE

This small study explored whether gentle electrical stimulation to the brain's surface could help control the depression, anxiety, and impulsive behaviors that often accompany Parkinson's disease. Five patients who were already having surgery for a standard deep brain stimulator …

This study tested a new oral medication, CVN424, to see if it could help control the symptoms of early Parkinson's disease in people not yet taking standard treatments. Over 12 weeks, 64 participants were randomly assigned to take either the drug or a placebo pill. The main goal …

This study tested whether one year of regular aerobic exercise, like brisk walking or cycling, could slow the progression of Parkinson's disease. It involved 57 adults with Parkinson's who were randomly assigned to either follow an exercise program or continue their usual care. R…

This small, early-stage study tested the safety of a new gene therapy called BBM-P002 for people with advanced Parkinson's disease. Ten participants received a single dose of the therapy, which was injected directly into the brain during a surgical procedure. The main goal was to…

This early-stage study tested the safety of a new Parkinson's drug called BIIB094, which was given as an injection into the spinal fluid. Researchers enrolled 62 adults with Parkinson's disease to check for side effects and measure how the drug moves through the body. The main go…

This early-stage study tested the safety of a new gene therapy for Parkinson's disease. Fourteen participants with Parkinson's underwent a surgical procedure where a gene was delivered to a specific area of the brain. The goal was to see if this approach was safe and could help b…

This study tested a new type of deep brain stimulation (DBS) system designed to better target areas of the brain affected by Parkinson's disease. It involved 26 patients whose symptoms were not well-controlled by medication alone. The goal was to see if this more precise 'directi…

This study tested the safety of a new gene therapy for advanced Parkinson's disease. Researchers used a special surgical technique to deliver a gene (AAV2-GDNF) directly into the brain. The goal was to see if this gene could help produce a protective protein to support the brain …

This study tested whether a special brain scan (fMRI) could help diagnose Parkinson's disease earlier. Researchers scanned the brains of 23 newly diagnosed patients and healthy volunteers to see if a specific area involved in vision reacts differently. The goal was to find a new …

This study tested whether clonidine, a medication commonly used for high blood pressure, could help reduce impulsive and compulsive behaviors in people with Parkinson's disease. Thirty-eight participants with Parkinson's and significant impulse control issues were randomly assign…

This study tested whether deep brain stimulation targeting a specific walking-control area of the brain could improve gait and balance problems in people with advanced Parkinson's disease. Six participants with severe walking issues that didn't respond well to standard medication…

This study tested whether an 8-week online mindfulness course could improve quality of life, mood, and thinking skills for people with Parkinson's disease. Researchers compared the mindfulness course to a standard support group in 107 participants. They measured results right aft…

This small study tested whether a special augmented reality headset could safely help Parkinson's patients who have deep brain stimulators. The headset displayed mental tasks while patients practiced walking exercises, aiming to improve their balance and walking ability. Research…

This small, early-stage study tested whether combining aerobic exercise with virtual reality (VR) games could help improve walking, balance, and thinking skills in people with Parkinson's disease. Ten participants did aerobic workouts followed by VR sessions. Researchers measured…

This study tested whether gentle electrical stimulation of a nerve near the ankle could improve bladder control problems in people with Parkinson's disease. 110 participants used either the real stimulation device or a placebo device for 20 minutes daily over 3 months. Researcher…

This study tested whether repeated ketamine infusions could safely reduce depression in people with Parkinson's disease. Fifty-one participants with both conditions received either ketamine or a placebo infusion. Researchers also used brain scans on some participants to understan…

This small study tested whether a video game-based rehabilitation program is practical and acceptable for people with Parkinson's disease who have ongoing walking and balance problems, despite having a deep brain stimulator. It involved 10 participants to see if they could and wo…

This small, exploratory study tested whether a device that stimulates the spinal cord could improve walking problems in people with Parkinson's disease. It involved five patients whose walking and 'freezing' episodes were not adequately controlled by their regular medications. Th…

This study tested whether a non-invasive brain stimulation technique could reduce chronic musculoskeletal pain in people with Parkinson's disease. Researchers used repetitive transcranial magnetic stimulation (rTMS) on 62 participants to target the brain's motor cortex, aiming to…

This study tested three different non-invasive treatments to help people with swallowing problems caused by stroke or Parkinson's disease. 110 patients tried either gentle brain stimulation or muscle stimulation therapy, combined with speech therapy, over six weeks. The goal was …

This study tested whether a home-based speech and exercise program delivered through telemedicine could help people with Parkinson's disease speak more clearly. It involved 104 Veterans with Parkinson's who had speech difficulties. The goal was to see if this remote program could…

This online study aimed to understand how vision, unusual perceptions, and hallucinations relate to other aspects of life for people with Parkinson's disease. Researchers surveyed 54 participants about their experiences, mood, sleep, and quality of life. The goal was to gather kn…

This study aimed to learn more about how the brain controls movement and what goes wrong in disorders like Parkinson's disease and Tourette's syndrome. Researchers compared over 1,200 healthy volunteers with about 1,000 patients using non-invasive brain scans and tests. The goal …

This study aimed to better understand how Parkinson's disease affects the brain over time. Researchers used special brain scans (PET scans) to measure changes in two key chemical systems—dopamine and serotonin—in 49 people at different stages of Parkinson's. The goal was to see h…

This study aimed to understand how deep brain stimulation (DBS) treatment affects the way people with Parkinson's disease interpret social situations. Researchers worked with 32 French-speaking adults with Parkinson's to see if DBS changes a thinking pattern called 'attributional…

This study aimed to understand how specific gene mutations contribute to Parkinson's disease. Researchers collected blood samples and genetic data from 2,934 people, including patients with Parkinson's and healthy family members. The goal was to create a detailed catalog of mutat…

This study aimed to understand how essential tremor happens in the brain and how deep brain stimulation (DBS) therapy helps control it. Researchers recorded brain signals from 21 people with essential tremor or Parkinson's disease while they were having DBS surgery. By listening …

This study aimed to understand why people with Parkinson's disease often have severe balance and walking problems that don't improve with standard medications. Researchers tested 60 people with Parkinson's to see if these issues might be linked to changes in the inner ear's balan…

This study used special brain scans (PET scans) to measure dopamine activity and blood flow in the brains of healthy volunteers, people with Parkinson's disease, and people with schizophrenia. Researchers compared these measurements across groups to better understand how dopamine…

This study is following up with about 89,000 farmers and their spouses to better understand the long-term health effects of farming exposures like pesticides. Researchers are checking the accuracy of health problems participants have reported, such as asthma and Parkinson's disea…

This was the first study in humans to test the safety of a new experimental drug called UCB0022 for Parkinson's disease. Researchers gave different doses to 100 healthy volunteers and people with Parkinson's to check for side effects and see how the body processes the drug. The s…

This study looked at whether following the DASH diet, known for heart benefits, was linked to better heart health markers in people with Parkinson's disease. Researchers measured diet habits, body measurements, and blood markers in 70 participants. The goal was to gather informat…