PARKINSON'S DISEASE

This early-phase study tested a gene therapy that delivers a protective protein (GDNF) directly to the brain in 25 people with advanced Parkinson's disease. The goal was to see if it is safe and to gather early information on whether it might help protect dopamine-producing brain…

This phase 3 trial tested a new drug called HRG2010 in 165 people with Parkinson's disease who experience motor fluctuations—times when their symptoms return before the next dose. The study compared HRG2010 to a standard sustained-release levodopa to see if it could reduce daily …

This study tested whether people with ALS or Parkinson's disease, along with healthy volunteers, could follow the MIND diet — a mix of the Mediterranean and DASH diets thought to protect the brain. Over several weeks, 43 participants received a cookbook, educational materials, an…

This study looked at whether a newer type of deep brain stimulation (DBS) electrode, which can steer electrical signals more precisely, improves mood and movement in people with Parkinson's disease. 105 participants received the directional electrodes as part of their standard ca…

This early-phase study tested whether low-dose lithium aspartate (30-45 mg/day) could slow Parkinson's disease in 15 people diagnosed within the last 4 years. Researchers measured changes in brain scans and blood markers linked to disease progression. The goal was to see if lithi…

This study tested whether a drug called deferiprone can safely reduce harmful iron buildup in the brains of people with early-stage Parkinson's disease. Forty participants took either deferiprone or a placebo for six months. The goal was to see if lowering brain iron could slow t…

This study tested whether exenatide, a drug already used for type 2 diabetes, can slow the progression of Parkinson's disease. About 194 people with early-stage Parkinson's received either exenatide or a placebo once a week for two years. The goal was to see if the drug could pro…

This small safety trial tested a device called ExAblate that uses focused ultrasound to create a tiny lesion in the brain area linked to Parkinson's motor symptoms. Seven people with advanced Parkinson's took part to see if the procedure is safe and might improve movement. The go…

This early-phase trial tested a new stem cell treatment for Parkinson's disease in 12 people who had been diagnosed at least 5 years earlier. The treatment uses dopamine-producing cells made from embryonic stem cells, injected into the brain. The main goal was to check safety, bu…

This study tested a new drug called CVN424 in 64 people with early Parkinson's disease who were not yet taking any Parkinson's medications. For 12 weeks, half received CVN424 and half received a placebo. The goal was to see if CVN424 could improve both motor symptoms (like moveme…

This study tested whether long-term aerobic walking can slow the progression of Parkinson's disease. 57 people with mild-to-moderate Parkinson's walked for 150 minutes per week at a moderate pace. Researchers measured changes in movement, thinking, driving safety, and brain healt…

This early-phase study tested a gene therapy called BBM-P002 in 10 people with advanced Parkinson's disease. The treatment is given as a single injection directly into the brain during a neurosurgical procedure. The main goal was to check safety, but researchers also looked for s…

This study tested a new deep brain stimulation (DBS) system that uses directional leads to treat Parkinson's disease. 26 adults with Parkinson's whose symptoms were not well controlled by medication took part. The goal was to see if the system could improve motor function and qua…

This early-stage trial tested the safety of a new drug called BIIB094 in 62 adults with Parkinson's disease. The drug was given as a spinal injection to see if it is safe and how the body processes it. The study included people with and without certain genetic variations. Results…

This early-stage trial tested a gene therapy for Parkinson's disease. The treatment involved delivering a gene called GAD into a brain region that controls movement. Only 14 people took part, and the main goal was to check safety, not whether it works. The study is now complete.

This study tested whether a brain scan (fMRI) can detect early signs of Parkinson's disease by looking at a part of the brain called the superior colliculus. Researchers compared newly diagnosed Parkinson's patients (not yet on medication) with healthy volunteers. The goal is to …

This study tested whether virtual reality exercises can improve balance and mobility in people with Parkinson's disease as well as or better than standard physical therapy. Sixty-two participants were split into two groups: one did virtual reality therapy and the other did conven…

This study tested whether a gentle, non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) can improve movement problems in people with Parkinson's disease. Thirty-seven participants received either real or sham stimulation over 10 se…

This pilot study compares two types of virtual reality (VR) rehabilitation for people with Parkinson's disease: immersive VR using a headset and non-immersive VR using a tablet. The goal is to see which approach better improves walking, balance, and thinking skills. Sixteen parti…

This study tested whether an apomorphine pump can improve quality of life for people in the early stages of Parkinson's disease who have just started experiencing motor complications. 134 adults aged 65 or younger with mild Parkinson's used either the pump plus standard care or s…

This study looked at whether a structured 8-week mindfulness-based stress reduction (MBSR) program is practical for people with Parkinson's disease. Thirty-one participants were enrolled to see how many could complete the program, including weekly group sessions and a full medita…

This study tested a wearable system (a haptic module and insole device) designed to detect freezing of gait in people with Parkinson's disease and then trigger cues to help them start walking again. The study enrolled 31 participants and aimed to validate the device's performance…

This study tested whether a non-invasive ultrasound treatment can improve movement in people with Parkinson's disease. Ten participants received both real and placebo treatments in a random order, with neither they nor the evaluators knowing which was which. The main goal was to …

This study tested whether high doses of methylphenidate (Ritalin) could improve walking and attention in 69 people with advanced Parkinson's disease who still had severe gait problems despite standard treatments. Participants received either methylphenidate or a placebo for three…

This study tested whether memantine, a drug that reduces overactive brain signals, can improve walking and attention in people with advanced Parkinson's disease. Twenty-eight non-demented patients with severe gait issues took memantine or a placebo for three months. The goal was …

This study tested whether dihydroergotine mesylate extended-release tablets can reduce drooling in people with Parkinson's disease. 120 patients took either the drug or a placebo for 12 weeks. Researchers measured changes in saliva weight and also looked at effects on thinking sk…

This study tested a psychological intervention to help people with Parkinson's disease who experience freezing of gait triggered by anxiety. 41 participants learned strategies to manage stress and attention while walking. The goal was to see if this approach could reduce the time…

This study tested a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for musculoskeletal pain in people with Parkinson's disease. Researchers aimed to see if stimulating a specific brain area could reduce pain and improve quality of life. 62 parti…

Nearly 90% of people with Parkinson's disease experience speech problems. This study tested a home-based program combining speech exercises and physical activity, delivered via telemedicine, to improve speech intelligibility. 104 veterans with Parkinson's and speech impairment pa…

This study tested whether electrical stimulation of the spinal cord could improve walking in people with Parkinson's disease whose symptoms are not well controlled by medication. Five participants received a spinal cord stimulator, and researchers measured changes in walking abil…

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to expl…

This study tested whether a daily 20-minute nerve stimulation (TENS) applied to the ankle could improve bladder control in people with Parkinson's disease or multiple system atrophy. A total of 110 participants used either an active or a sham device for 3 months. The main goal wa…

This study tested whether stimulating the front part of the brain could improve mood and behavioral symptoms in people with Parkinson's disease. Five participants received a special brain device that could record and stimulate brain activity. The goal was to see if this approach …

This study tested whether an 8-week mindfulness program (MBSR) could improve quality of life, thinking, and mood in 107 people with Parkinson's disease. Participants were randomly assigned to MBSR or a supportive education group, with sessions held online due to COVID-19. The goa…

This study tested a new drug called UCB0022 in 100 healthy volunteers and people with Parkinson's disease. The main goal was to check if the drug is safe and how the body processes it. This is an early-stage trial, so it does not prove the drug works for Parkinson's symptoms yet.

This small study tested whether combining aerobic exercise with virtual reality games could improve thinking, walking, and balance in people with Parkinson's disease. Ten participants used a recumbent stepper while playing VR games. The goal was to see if this approach is feasibl…

This small study tested a digital therapy called DART that uses augmented reality to help people with Parkinson's disease and a deep brain stimulator improve their walking and balance. Seven adults participated, and researchers measured changes in motor function and walking dista…

This study tested whether deep brain stimulation of a specific brain region could improve walking and balance in people with advanced Parkinson's disease. Six participants received both real and sham stimulation in a blinded crossover design. The goal was to see if this approach …

This pilot study tested whether clonidine, a drug used for high blood pressure, can reduce impulse control disorders (like gambling or overeating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The study measured changes in…

This study tested two non-invasive treatments—brain stimulation (tDCS) and neuromuscular electrical stimulation (NMES)—to help people with swallowing difficulties caused by stroke or Parkinson's disease. A total of 110 adults aged 18 to 85 took part. The goal was to see if these …

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This completed study looked at how the drug deferiprone affects blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers. Researchers measured markers of oxidative stress and iron levels in the lab. The goal was to better understand these diseases, not to t…

This study looked at how brain circuits in people with Parkinson's disease produce abnormal electrical rhythms. Researchers measured these rhythms in 23 patients with implanted brain electrodes. The goal was to understand why these patterns occur, which could lead to better treat…

This study followed 700 Parkinson's patients who received deep brain stimulation to see which factors predict a meaningful improvement in quality of life after 1, 3, and 5 years. Researchers analyzed clinical, imaging, and genetic data to identify who benefits most. The goal is t…

This study looked at two different strength training methods in 38 people with mild to moderate Parkinson's disease. One method focused on fast, powerful movements, while the other cycled through different training phases. The goal was to see which approach better improved muscle…

This study observed over 20,000 people with Parkinson's disease to find genetic links and potential biomarkers. Participants were between 30 and 80 years old and diagnosed within the last 5 years. No treatments were tested; the goal was to better understand the disease's genetic …

This study looked at whether balance and walking problems in people with Parkinson's disease are caused by changes in the inner ear (vestibular system) rather than just a lack of dopamine in the brain. 60 participants with Parkinson's underwent balance tests and brain scans. The …

This study looked at 70 people with Parkinson's disease to see if following the DASH diet (a heart-healthy eating plan) was linked to better heart health. Researchers measured blood fats, inflammation, and other risk markers. They found that those who followed the DASH diet more …

This study looked at how deep brain stimulation (DBS) changes the way people with Parkinson's disease explain positive and negative events, known as attributional style. Researchers measured this in 32 French-speaking adults with Parkinson's who had stable treatment. The goal was…

This study looked at the DNA of 2500 people, including those with Parkinson's disease and healthy volunteers, to find genetic changes linked to the condition. Researchers focused on specific genes like parkin, DJ-1, PINK1, and LRRK2. The goal was to better understand the disease'…

This study looked at brain signals in 21 people with essential tremor or Parkinson's disease during deep brain stimulation (DBS) surgery. Researchers placed temporary recording strips on the brain's surface to capture electrical activity. The goal was to learn how DBS calms the t…

This study tested whether adding lateral stepping exercises to a regular group exercise class is feasible and helpful for people with middle to late-stage Parkinson's disease. Five participants did the exercises twice a week for 8 weeks. Researchers measured balance, fall risk, a…

This study used PET scans to examine brain changes in people with Parkinson's disease at different stages. Researchers looked at two brain chemical systems—dopamine and serotonin—to understand non-motor symptoms like mood and thinking problems. 49 participants, including healthy …

This study looked at whether a special video game could help improve walking and balance in 10 people with Parkinson's disease who had already had brain surgery. The goal was to see if the game was easy and enjoyable to use. Researchers measured how well participants could walk a…

This completed observational study looked at how people with Parkinson's disease perceive the world, including unusual experiences like visual hallucinations. Researchers surveyed 54 participants online to see how these perceptual experiences relate to cognition, mood, and sleepi…