Brain gene therapy tested for Parkinson's – early results in
NCT ID NCT05603312
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tested a gene therapy for Parkinson's disease. The treatment involved delivering a gene called GAD into a brain region that controls movement. Only 14 people took part, and the main goal was to check safety, not whether it works. The study is now complete.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AAV-GAD (gene therapy)
What this could lead to
If successful, this could point toward a new way to control Parkinson's symptoms by delivering a gene that helps calm overactive brain signals.
What could go wrong
This was a very small, early-phase trial focused on safety, not effectiveness. The gene therapy requires brain surgery, which carries risks like infection or bleeding. It may not improve symptoms.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PARKINSON'S DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Columbia University Irving Medical Center
New York, New York, 10032, United States
-
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322, United States
-
Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
-
Weill Cornell Medicine
New York, New York, 10021, United States
-
West Virginia University
Morgantown, West Virginia, 26506, United States
-
Yale University - Yale New Haven Hospital
New Haven, Connecticut, 06510, United States