Could a blood pressure drug curb impulsive behaviors in Parkinson's?

NCT ID NCT03552068

Completed Symptom relief Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This pilot study tested whether clonidine, a drug used for high blood pressure, can reduce impulse control disorders (like gambling or overeating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The study measured changes in impulsive behavior using a special questionnaire. It's an early, small trial to see if this approach is worth further study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clonidine
What this could lead to: If it works, this could point toward a new treatment for impulse control problems in Parkinson's disease.
What could go wrong: This is a very small pilot study (38 people) and only a proof of concept. Clonidine is a blood pressure drug, so it may cause side effects like low blood pressure or drowsiness, and it may not help at all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Disruptive, Impulse Control, and Conduct Disorders impulse control disorder Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MPULSE CONTROL DISORDERS PARKINSON'S DISEASE

Contacts and locations

Locations

Hospices Civils de Lyon

Bron, France

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